Horizontal Natural Product Transfer: A Phenomenon Which Is Responsible for the Widespread Alkaloidal Contaminations of Herbal Products

Hijazin, Tahani; Lewerenz, Laura; Yahyazadeh, Mahdi; Selmar, Dirk

doi:10.1007/978-3-030-92050-0_7

Cited by 2 publications

(5 citation statements)

References 80 publications

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“…Indeed, numerous alkaloid transporters are described in the literature [ 54 , 55 , 56 ], for review see [ 57 ]. Unfortunately, in most of these reports, the ability of alkaloids to easily pass biomembranes is entirely ignored, and the authors are not aware that the transporters are required for the membrane transfer of protonated alkaloids rather than for the free bases [ 27 ].…”

Section: Horizontal Natural Product Transfer—basic Principles and Cog...mentioning

confidence: 99%

“…From the coherences mentioned above—in particular that the extent and mode of modification of the imported products strongly vary between plant species—the occurrence of a general detoxification system, hypothesized as “green liver concept” [ 69 , 71 ], has to be doubted. In contrast, the imported substances seem to be accidentally modified by enzymes involved in the inherent specialized metabolism, which are present in some plants and absent in others [ 27 ].…”

Section: Horizontal Natural Product Transfer—basic Principles and Cog...mentioning

confidence: 99%

“…Depending on the plant species, the specialized metabolism and thus, the composition of immanent enzymes, massively differs. In consequence—in analogy to the proposed random modification of xenobiotics [ 27 ]—in some plants the imported allelochemicals might also be modified “accidentally”, whereas in others, they are not. However, in contrast to allelopathic interactions which represent quite ancient features, plants had been confronted with xenobiotics, i.e., herbicides or fungicides only for one and a half century.…”

Section: Horizontal Natural Product Transfer and Allelopathymentioning

confidence: 99%

“…Accordingly, such transfer of alkaloids—at least in part—accounts for the numerous and widespread alkaloidal contaminations of spice and medicinal plants reported comprehensively [ 15 , 16 , 23 ]. Based on these coherences, the so-called “Horizontal Natural Product Transfer” was outlined [ 24 ], a so far unrecognized phenomenon which has been studied intensively during the last few years (for review, see [ 25 , 26 , 27 ]). It became evident that apart from alkaloids, other natural products, such as coumarins [ 28 ], stilbenes [ 29 ], or betalains [ 30 ], are also taken up by plant roots.…”

Section: Introductionmentioning

confidence: 99%

“…It became evident that apart from alkaloids, other natural products, such as coumarins [ 28 ], stilbenes [ 29 ], or betalains [ 30 ], are also taken up by plant roots. In this context, it has to be mentioned that in some cases, the natural products whose import into acceptor plants was verified, i.e., the stilbene resveratrol [ 29 ] or the coumarins [ 27 ], are known to exhibit allelopathic effects [ 31 , 32 ]. These examples vividly demonstrate that the line between “simple natural products” and “allelochemicals”, which are leached out, is quite diffuse.…”

Section: Introductionmentioning

confidence: 99%

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Novel Cognitions in Allelopathy: Implications from the “Horizontal Natural Product Transfer”

Lewerenz

Abouzeid

Yahyazadeh

et al. 2022

Plants

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Whereas the translocation of allelochemicals between plants is well established, a related general transfer of genuine specialized metabolites has not been considered so far. The elucidation of the so-called “Horizontal Natural Product Transfer” revealed that alkaloids, such as nicotine and pyrrolizidine alkaloids, which are leached out from decomposing alkaloid-containing plants (donor plants), are indeed taken up by the roots of plants growing in the vicinity (acceptor plants). Further studies demonstrated that phenolic compounds, such as coumarins or stilbenes, are also taken up by acceptor plants. Contemporary analyses from co-cultivation experiments outlined that natural products are not exclusively transferred from dead and rotting donor plant materials, but also from vital plants. In analogy to xenobiotics, the imported specialized metabolites might also be modified within the acceptor plants. As known from the uptake of xenobiotics, the import of specialized metabolites is also generally due to a simple diffusion of the substances across the biomembranes and does not require a carrier. The uptake depends in stricto sensu on the physicochemical properties of the certain compound. This article presents a current overview of the phenomenon of “Horizontal Natural Product Transfer” and discusses its relevance for our understanding of allelopathic interactions. The knowledge that specialized metabolites might in general be readily translocated from one plant into others should significantly contribute to our understanding of plant–plant interactions and—in particular—to the evolution of typical allelopathic effects, such as inhibition of growth and germination of potential competitors.

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Section: Horizontal Natural Product Transfer—basic Principles and Cog...mentioning

confidence: 99%

Section: Horizontal Natural Product Transfer—basic Principles and Cog...mentioning

confidence: 99%

Section: Horizontal Natural Product Transfer and Allelopathymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Novel Cognitions in Allelopathy: Implications from the “Horizontal Natural Product Transfer”

Lewerenz

Abouzeid

Yahyazadeh

et al. 2022

Plants

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The Status of Research on the Root Exudates of Submerged Plants and Their Effects on Aquatic Organisms

Shi,

Zhang,

Zhao

et al. 2024

Water

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The ecological restoration of submerged plants is one of the most widely used technologies in the remediation of eutrophic water bodies. This technology mainly removes nitrogen, phosphorus, and other nutrients in water through the absorption effects of plant roots, stems, and leaves and the biotransformation of microorganisms attached to their surfaces. Root exudates can directly affect root-attached microorganisms and other aquatic organisms, thus significantly influencing water remediation by submerged plants. At present, there are few reviews on the root exudates of submerged plants and their effects on aquatic organisms. In this study, the composition, collection, and methods of detecting the root exudates of submerged plants are reviewed. Factors affecting the release of root exudates from submerged plants are analyzed, including abiotic (light, temperature, and nutritional status) and biotic factors (rhizosphere microorganisms). The positive or negative effects of root exudates on phytoplankton, zooplankton, and microorganisms are also discussed. The results show that plant species, growth stages, and environmental factors (light, temperature, and nutritional status) are crucial factors affecting root exudates. In addition, submerged plants can significantly influence phytoplankton, zooplankton, and microorganisms by releasing allelochemicals or other root exudates. Based on the results of this study, the influencing mechanisms of root exudates on ecological restoration processes by submerged plants are clarified. This review provides important guiding significance for applying submerged macrophytes in water restoration.

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Horizontal Natural Product Transfer: A Phenomenon Which Is Responsible for the Widespread Alkaloidal Contaminations of Herbal Products

Cited by 2 publications

References 80 publications

Novel Cognitions in Allelopathy: Implications from the “Horizontal Natural Product Transfer”

Novel Cognitions in Allelopathy: Implications from the “Horizontal Natural Product Transfer”

The Status of Research on the Root Exudates of Submerged Plants and Their Effects on Aquatic Organisms

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