2021
DOI: 10.1021/acsomega.1c02127
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Hormesis Effect of Methyl Triclosan on Cell Proliferation and Migration in Human Hepatocyte L02 Cells

Abstract: Methyl triclosan (mTCS) is a methylated derivative of triclosan (TCS), which is extensively used as an antimicrobial component of various nursing products and disinfectants. Current research studies of mTCS mainly focused on the environmental persistence and bioaccumulation potential. Knowledge regarding the toxicity and carcinogenicity of mTCS is limited until now. In this study, the human hepatocyte L02 cells were used to investigate the cellular effects of mTCS under different concentrations (0.1–60 μM). Th… Show more

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Cited by 9 publications
(3 citation statements)
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“…Cell viability (%) of pressure-spun TPP fibrous sutures shows a decreasing trend as the Tri content increases compared to the negative control. This finding aligns with previous studies in the literature, which have shown that the incorporation of antibacterial agents, such as Tri, can have an impact on cell viability. The cytotoxicity of Tri has been reported with respect to various cell types, and its effects can be dose-dependent . It is worth noting that in this study the cell viability remains at 70% and above, up to the 20 TPP sample.…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…Cell viability (%) of pressure-spun TPP fibrous sutures shows a decreasing trend as the Tri content increases compared to the negative control. This finding aligns with previous studies in the literature, which have shown that the incorporation of antibacterial agents, such as Tri, can have an impact on cell viability. The cytotoxicity of Tri has been reported with respect to various cell types, and its effects can be dose-dependent . It is worth noting that in this study the cell viability remains at 70% and above, up to the 20 TPP sample.…”
Section: Resultssupporting
confidence: 92%
“… 55 57 The cytotoxicity of Tri has been reported with respect to various cell types, and its effects can be dose-dependent. 58 It is worth noting that in this study the cell viability remains at 70% and above, up to the 20 TPP sample. However, as the Tri content further increases, it is observed that the cell viability decreases.…”
Section: Resultsmentioning
confidence: 55%
“…Cell migration was studied by the IncuCyte scratch assay modified by An et al 22 The results showed that NDF, DDF, and DWF treated with film extract for 24 h elucidated a completely healed scratch after 48 h, while under other conditions (DMEM with 0% FBS and DMEM with 2% FBS), they exhibit no wound closure at the same time, as shown in Figure 4 A. At 48 h, percentages of relative wound density for NDF, DDF, and DWF treated with film extract were 99.73 ± 5.01, 98.01 ± 2.90, and 93.47 ± 2.86%, respectively, which reached approximately 100% of relative wound density, whereas they were lower for NDF, DDF, and DWF cultured with DMEM with 0% FBS (32.65 ± 3.52, 37.01 ± 1.75, and 38.63 ± 2.36%) and DMEM with 2% FBS (68.15 ± 4.91, 59.37 ± 6.85, and 48.27 ± 2.71%) ( Figure 4 B).…”
Section: Resultsmentioning
confidence: 99%