Hormon anty-müllerowski i zespół policystycznych jajników

Łebkowska, Agnieszka; Kowalska, Irina

doi:10.5603/ep.a2016.0065

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…Additionally, we found impaired glucose metabolism in L/L group of rats, which was consistent with manifestation of PCOS in patients (Dumont et al, 2015;Łebkowska and Kowalska, 2017). Lower basal insulin level and HOMA-β indicated poorer β-cell secretion and function after continuous light exposure.…”

Section: Discussionsupporting

confidence: 81%

Continuous Light-Induced PCOS-Like Changes in Reproduction, Metabolism, and Gut Microbiota in Sprague-Dawley Rats

Chu

Zhai

et al. 2020

Front. Microbiol.

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Section: Discussionsupporting

confidence: 81%

Continuous Light-Induced PCOS-Like Changes in Reproduction, Metabolism, and Gut Microbiota in Sprague-Dawley Rats

Chu

Zhai

et al. 2020

Front. Microbiol.

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“…AMH levels start to rise by much as 17% three years before puberty and declines by 30% within the first 2 years of puberty. Several studies have reported higher AMH levels in women with PCOS [35-37]. Crisosto et al [38] showed higher (AMH) levels in prepubertal and peripubertal daughters of PCOS women, suggesting that these girls may have an altered follicular development which starts early in development and continues through puberty.…”

Section: Discussionmentioning

confidence: 99%

Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Brar

Dingle

Ovadia

et al. 2018

Ann Pediatr Endocrinol Metab

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PurposePremature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls.MethodsRetrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done.ResultsPA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, P<0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups.ConclusionsHigher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.

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“…In PCOS diagnostics, determination of anti-Mullerian hormone (AMH) is not recommended due to lack of standardisation and low sensitivity of this method, and due to no cut-off value accepted as a standard [2,12]. AMH concentrations in the group of PCOS women are higher than in the group of healthy women and are well correlated with antral follicles in an ovary [28]. The concept was postulated in PCOS diagnosis to apply AMH concentration convertible with the number of antral follicles found in ultrasound examination.…”

Section: Clinical and Biochemical Characteristics Of Hyperandrogenismmentioning

confidence: 99%

Stanowisko Polskiego Towarzystwa Endokrynologicznego, Polskiego Towarzystwa Ginekologów i Położników oraz Polskiego Towarzystwa Endokrynologii Ginekologicznej w sprawie diagnostyki i leczenia zespołu policystycznych jajników

Milewicz¹,

Kudła²,

Spaczyński³

et al. 2018

Endokrynologia Polska

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Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the Rotterdam criteria, which is two out of three of the follwing characteristics: a) ovulation abnormality, b) clinical or biochemical hyperandrogenism, and c) polycystic ovaries. In the case of teenagers, diagnostic criteria are as follows: menstruation disturbances two years after menarche and clinical or biochemical hyperandrogenism. The presence of polycysti-cally abnormal ovaries is not necessary. The consensus paper presents the threats resulting from imperfect diagnostic methods applied in PCOS (hyperandrogenism diagnostics, ultrasound examination of ovaries). Suggested therapy includes personalised schemes according to the dominant PCOS phenotype, i.e. metabolic, hyperandrogenic, or reproductive ones.

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Hormon anty-müllerowski i zespół policystycznych jajników

Cited by 4 publications

References 53 publications

Continuous Light-Induced PCOS-Like Changes in Reproduction, Metabolism, and Gut Microbiota in Sprague-Dawley Rats

Continuous Light-Induced PCOS-Like Changes in Reproduction, Metabolism, and Gut Microbiota in Sprague-Dawley Rats

Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Stanowisko Polskiego Towarzystwa Endokrynologicznego, Polskiego Towarzystwa Ginekologów i Położników oraz Polskiego Towarzystwa Endokrynologii Ginekologicznej w sprawie diagnostyki i leczenia zespołu policystycznych jajników

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