Hormonal and Autacoid Control of Cardiac Function

Imbrogno, Sandra; Cerra, Maria Carmela

doi:10.1016/bs.fp.2017.05.001

Cited by 15 publications

(10 citation statements)

References 215 publications

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“…In fish, the role of NO as a major organizer of complex cardiac transduction signals has been widely assessed, and to date many data are available about its wide cardiac repertoire of actions (see for example Garofalo et al, 2009a , 2012 ; Imbrogno et al, 2010 , 2013 , 2017 , 2018 ; Filice et al, 2017 ; Imbrogno and Cerra, 2017 ). Very recent studies extended the large variety of NO functions in fish to the mechanisms which allow to maintain the cardiovascular status and control the response to low O 2 .…”

Section: Cardiac Nitrosative Signalsmentioning

confidence: 99%

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

Gattuso¹,

Garofalo²,

Cerra³

et al. 2018

Front. Physiol.

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Changes in environmental oxygen (O2) are naturally occurring phenomena which ectotherms have to face on. Many species exhibit a striking capacity to survive and remain active for long periods under hypoxia, even tolerating anoxia. Some fundamental adaptations contribute to this capacity: metabolic suppression, tolerance of pH and ionic unbalance, avoidance and/or repair of free-radical-induced cell injury during reoxygenation. A remarkable feature of these species is their ability to preserve a normal cardiovascular performance during hypoxia/anoxia to match peripheral (tissue pO2) requirements. In this review, we will refer to paradigms of hypoxia- and anoxia-tolerant teleost fish to illustrate cardiac physiological strategies that, by involving nitric oxide and its metabolites, play a critical role in the adaptive responses to O2 limitation. The information here reported may contribute to clarify the molecular and cellular mechanisms underlying heart vulnerability vs. resistance in relation to O2 availability.

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Section: Cardiac Nitrosative Signalsmentioning

confidence: 99%

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

Gattuso¹,

Garofalo²,

Cerra³

et al. 2018

Front. Physiol.

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“…The influence elicited by NO on the heart has been widely assessed in mammals, and also in fish, for which many data are now available (see for example [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]). More recently, the role of NO in fish has been extended to the mechanisms which maintain cardiac health under hypoxia (see, for references, [ 10 ]).…”

Section: Introductionmentioning

confidence: 99%

The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond

et al. 2020

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The extraordinary capacity of the goldfish (Carassius auratus) to increase its cardiac performance under acute hypoxia is crucial in ensuring adequate oxygen supply to tissues and organs. However, the underlying physiological mechanisms are not yet completely elucidated. By employing an ex vivo working heart preparation, we observed that the time-dependent enhancement of contractility, distinctive of the hypoxic goldfish heart, is abolished by the Nitric Oxide Synthase (NOS) antagonist L-NMMA, the Nitric Oxide (NO) scavenger PTIO, as well as by the PI3-kinase (PI3-K) and sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) pumps’ inhibition by Wortmannin and Thapsigargin, respectively. In goldfish hearts exposed to hypoxia, an ELISA test revealed no changes in cGMP levels, while Western Blotting analysis showed an enhanced expression of the phosphorylated protein kinase B (pAkt) and of the NADPH oxidase catalytic subunit Nox2 (gp91phox). A significant decrease of protein S-nitrosylation was observed by Biotin Switch assay in hypoxic hearts. Results suggest a role for a PI3-K/Akt-mediated activation of the NOS-dependent NO production, and SERCA2a pumps in the mechanisms conferring benefits to the goldfish heart under hypoxia. They also propose protein denitrosylation, and the possibility of nitration, as parallel intracellular events.

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“…). Also in poikilotherms, NO influences the cardiac contractility with effects that are species‐specific and dependent on the experimental conditions . It is now well recognized that the specific subcellular localization and regulation of the different NOS isoforms, and of NO target proteins allow NO to achieve a spatio‐temporal control of different cellular functions .…”

Section: No As a Cardiac Modulator: Mammals Vs Poikilothermsmentioning

confidence: 99%

“…In poikilotherm vertebrates, the heart is a clear example of organ morpho‐functional flexibility. As largely documented in fish and amphibians, it supports the varying requirements of the animal by adjusting metabolism and haemodynamics in response to extrinsic and intrinsic stimuli, including circulating and intracardiac hormones and humoral autacoids (ie locally generated signalling substances) . Under normal and stressful conditions, these substances modulate the heart acting beat‐to‐beat (Frank‐Starling response), as well as in the short (myocardial contractility, excitation‐contraction coupling)‐ and long‐term (gene expression) .…”

Section: Introductionmentioning

confidence: 96%

“…In this context, locally released autacoids, such as NO, CO and H 2 S, play a remarkable role. This is exemplified by the NOS/NO system that, in teleost fish and amphibian heart, acts as a major integrative mechanism that coordinates humoral signals and the crosstalk between the different cardiac regions (ie the endocardial endothelium [EE] and the myocardium), thus contributing to the morphological and functional integration which is essential for proper organ function …”

Section: Introductionmentioning

confidence: 99%

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NO, CO and H₂S: What about gasotransmitters in fish and amphibian heart?

et al. 2018

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The gasotransmitters nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H S), long considered only toxicant, are produced in vivo during the catabolism of common biological molecules and are crucial for a large variety of physiological processes. Mounting evidence is emerging that in poikilotherm vertebrates, as in mammals, they modulate the basal performance of the heart and the response to stress challenges. In this review, we will focus on teleost fish and amphibians to highlight the evolutionary importance in vertebrates of the cardiac control elicited by NO, CO and H S, and the conservation of the intracellular cascades they activate. Although many gaps are still present due to discontinuous information, we will use examples obtained by studies from our and other laboratories to illustrate the complexity of the mechanisms that, by involving gasotransmitters, allow beat-to-beat, short-, medium- and long-term cardiac homoeostasis. By presenting the latest data, we will also provide a framework in which the peculiar morpho-functional arrangement of the teleost and amphibian heart can be considered as a reference tool to decipher cardiac regulatory networks which are difficult to explore using more conventional vertebrates, such as mammals.

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Hormonal and Autacoid Control of Cardiac Function

Cited by 15 publications

References 215 publications

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond

NO, CO and H₂S: What about gasotransmitters in fish and amphibian heart?

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Hormonal and Autacoid Control of Cardiac Function

Cited by 15 publications

References 215 publications

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals

The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond

NO, CO and H2S: What about gasotransmitters in fish and amphibian heart?

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NO, CO and H₂S: What about gasotransmitters in fish and amphibian heart?