Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients with Polycystic Ovary Syndrome

Izadi, Azimeh; Ebrahimi, Sara; Shirazi, Shabnam; Taghizadeh, Sepehr; Parizad, Marziyeh; Farzadi, Laya; Gargari, Bahram Pourghassem

doi:10.1210/jc.2018-01221

Cited by 53 publications

(60 citation statements)

References 44 publications

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“…Similar results were reported in a few more randomized clinical trials, although with higher vitamin D dose [44] , [45] . Vitamin E was shown to have beneficial effects on the metabolic and clinical signs of PCOS, alone or in combination with coenzyme Q10 and omega-3 fatty acids [46] – [49] . Two physicians reported advising the use of herbal supplements ( Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

et al. 2020

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Background Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting up to 20% of pre-menopausal women. The most recent international guidelines set lifestyle management as the cornerstone of the PCOS treatment. Still, there is a paucity of data on the implementation of lifestyle management in clinical practice. This cross-sectional study aimed to explore physicians-reported practices in PCOS lifestyle management in the Sarajevo Canton, Bosnia and Herzegovina (BiH). The profession of dietetics is not legally recognized in BiH. Nutritional interventions in health promotion and disease treatment are provided by medical professionals. Methods Data were collected by a paper-based questionnaire distributed during March-May 2018 in the Public Institution Health Centre of Sarajevo Canton. Results Forty-six physicians (response rate of 80.7%) completed the questionnaire. An initial treatment plan based solely on lifestyle measures (diet + physical activity), as recommended by current guidelines was reported by 34.8% of physicians. Although dietary interventions were rated as highly relevant in PCOS management by the vast majority of physicians, only one-half reported recording patients' adherence and 45.7% of physicians were unsure of the effectiveness of the lifestyle interventions in their patients. Conclusion PCOS lifestyle management in the study setting is sub-optimal. Additional education on effective PCOS lifestyle management strategies would be beneficial, especially for physicians with less than 15 years in practice. Possible obstacles to better physicians' engagement in PCOS lifestyle management should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

et al. 2020

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“…In this study, it was found that CoQ10 with or without vitamin E supplementation for 8 weeks among patients with PCOS significantly decreased serum total testosterone levels (P < 0.001) compared with those of the placebo group. CoQ10 supplementation in combination with vitamin E significantly improved sex hormone-binding globulin (SHBG) levels compared with other groups (P = 0.008) [74].…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Role of Vitamin E in Pregnancy

Siddiqui¹,

Ahmad²,

Ali³

et al. 2021

Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects

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Vitamins play important roles in female health. They are essential for many functions, including menstruation and ovulation, oocyte (egg) quality and maturation. Vitamin E was first discovered in 1922 as a substance necessary for reproduction. It has become widely known as a powerful lipid-soluble antioxidant. There are various reports on the benefits of vitamin E on health in general. Vitamin E helps your body create and maintain red blood cells, healthy skin, eyes and strengthens your natural immune system. However, despite it being initially discovered as a vitamin necessary for reproduction, to date studies relating to its effects in this area are lacking. Vitamin E supplementation may help reduce the risk of pregnancy complications involving oxidative stress, such as pre-eclampsia. This chapter is written to provide a review of the known roles of vitamin E in pregnancy.

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“…TT was measured in 13 studies [25][26][27][28][29]32,33,[38][39][40]42,43,45]. TMA showed that except for vitamin D, the following nutritional agents were significantly different compared with PA: CoQ10 (MD À0.55, 95%CI À0.68 to À0.43, p < .00001, I 2 ¼ 62),vitamin E (MD À0.61, 95%CI À0.70 to À0.53, p < .0001, inositols (MD 0.55, 95%CI 0.34 to 0.77, p < .00001, I 2 ¼62).…”

Section: Improvement Of Hyperandrogenemiamentioning

confidence: 99%

The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis

Zhang

Xing

Zhao

et al. 2021

Gynecological Endocrinology

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Objective: This research evaluated the efficacy of oral nutritional agents including CoQ10, vitamin E, inositols and vitamin D on androgen-associated hormones, glycolipid metabolism and body weight in women with PCOS. Method: A multi-database search was performed from inception to December 2020. Using multi-variate random effects method, a NMA was conducted by synthesizing data pooled from RCTs. It was registered with PROSPERO (registration number CRD42021230292). Results: Twenty-three RCTs and 1291 participants were included. Based on NMA, CoQ10, vitamin E, CoQ10 combined with vitamin E, and inositols were successful in decreasing TT as compared with PA; vitamin E was superior to other agents. Vitamin E and inositols were successful in increasing SHBG levels; inositols were stronger than vitamin E. CoQ10 alone or combined with vitamin E, and inositols were successful in decreasing HOMA-IR. Inositols had the best results among included nutraceuticals to ameliorate HOMA-IR, FBG, FINS, TG, TC, and LDL-C and correlated to improvements in BMI. There was no significant difference between the CoQ10 or vitamin E group and the PA group in ameliorating lipid metabolism, and vitamin D had no positive effects in ameliorating hyperandrogenism, BMI, glycolipid metabolism profiles compared with PA. Conclusion: For women with PCOS, inositols supplementation have some certain advantages in increasing SHBG and improving glycolipid metabolism when compared with nutraceuticals like CoQ10, vitamin E, vitamin D. Besides, vitamin E may be a better option in reducing TT and increasing SHBG. CoQ10 alone or combined with vitamin E can be helpful in decreasing HOMA-IR as well.

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Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients with Polycystic Ovary Syndrome

Abstract: In conclusion, CoQ10 with or without vitamin E supplementation among women with PCOS had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels. However only co-supplementation was able to affect SHBG concentrations.

Cited by 53 publications

References 44 publications

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

Lifestyle management of polycystic ovary syndrome: a single-center study in Bosnia and Herzegovina

Role of Vitamin E in Pregnancy

The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis

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