Hormonal and non-hormonal bases of maternal behavior: The role of experience and epigenetic mechanisms

Stolzenberg, Danielle S.; Champagne, Frances A.

doi:10.1016/j.yhbeh.2015.07.005

Cited by 103 publications

(86 citation statements)

References 82 publications

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“…In rats, patterns of maternal care affect behavioral and neuroendocrine function in offspring through epigenetic regulation of gene expression (Stolzenberg and Champagne 2016), and a similar mechanism is likely to subserve early-life effects of paternal behavior as well. Elucidation of the specific genes that may be epigenetically regulated by paternal care, as well of interactions between these persistent epigenetic effects and shorter-term experiential influences, will yield important insights into the transgenerational transmission of paternal behavior.…”

Section: Discussionmentioning

confidence: 99%

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Saltzman

Harris

Jong

et al. 2017

Integrative and Comparative Biology

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Section: Discussionmentioning

confidence: 99%

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Saltzman

Harris

Jong

et al. 2017

Integrative and Comparative Biology

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“…The posterior cingulate has been implicated in sexual fidelity and space use in monogamous voles (Ophir et al, 2008). The medial preoptic area, while better known for its role in maternal memory (Dobolyi et al, 2014, Stolzenberg and Champagne, 2016), has also been implicated in oxytocinergic regulation of social recognition (Popik and van Ree, 1991). All of these areas were also previously implicated in our cross-sectional study of pair bonding in male titi monkeys (Bales et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

Pair bond formation leads to a sustained increase in global cerebral glucose metabolism in monogamous male titi monkeys (Callicebus cupreus)

et al. 2017

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Social bonds, especially attachment relationships, are crucial to our health and happiness. However, what we know about the neural substrates of these bonds is almost exclusively limited to rodent models and correlational experiments in humans. Here, we used socially monogamous non-human primates, titi monkeys (Callicebus cupreus) to experimentally examine changes in regional and global cerebral glucose metabolism during the formation and maintenance of pair bonds. Baseline positron emission tomography (PET) scans were taken of thirteen unpaired male titi monkeys. Seven males were then experimentally paired with females, scanned and compared, after one week, to six age-matched control males. Five of the six control males were then also paired and scanned after one week. Scans were repeated on all males after four months of pairing. PET scans were coregistered with structural magnetic resonance imaging (MRI), and region of interest (ROI) analysis was carried out. A primary finding was that paired males showed a significant increase in FDG uptake in whole brain following one week of pairing, which is maintained out to four months. Dopaminergic, “motivational” areas and those involved in social behavior showed the greatest change in glucose uptake. In contrast, control areas changed only marginally more than GCGM. These findings confirm the large effects of social bonds on global cerebral glucose metabolism. They also suggest that more studies should examine how social manipulations affect whole brain FDG uptake, as opposed to assuming that it does not change across condition.

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“…The quality of maternal care may “program” the genome through epigenetic mechanisms to modulate the stress response in the offspring (Weaver et al, 2004). Through epigenetic modifications, acquired traits such as maternal and paternal conditions (Champagne, 2016; Peter et al, 2016) (Ng et al, 2010), hormonal (Stolzenberg and Champagne, 2016) may be transmitted to offspring. In support of a link between cell metabolism and epigenetics, it has been shown that chronic consumption of a caloric diet can program pancreatic ß-cell dysfunction, impaired insulin secretion and glucose tolerance in the female rat offspring (Ng et al, 2010).…”

Section: Epigenetics Bridging Diet and Long-term Brain Plasticity (Fimentioning

confidence: 99%

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

Gómez‐Pinilla

Yang

2018

Progress in Neurobiology

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The surge in meals high in calories has prompted an epidemic of metabolic disorders around the world such that the elevated incidence of obese and diabetic individuals is alarming. New research indicates that metabolic disorders pose a risk for neurological and psychiatric conditions including stroke, Alzheimer’s disease, Huntington’s disease, and depression, all of which have a metabolic component. These relationships are rooted to a dysfunctional interaction between molecular processes that regulate energy metabolism and synaptic plasticity. The strong adaptive force of dietary factors on shaping the brain during evolution can be manipulated to trans form the interaction between cell bioenergetics and epigenome with the aptitude to promote long-lasting brain healthiness. A thorough understanding of the association between the broad action of nutrients and brain fitness requires high level data processing empowered with the capacity to integrate information from a multitude of molecular entities and pathways. Nutritional systems biology is emerging as a viable approach to elucidate the multiple molecular layers involved in information processing in cells, tissues, and organ systems in response to diet. Information about the wide range of cellular and molecular interactions elicited by foods on the brain and cognitive plasticity is crucial for the design of public health initiatives for curtailing the epidemic of metabolic and brain disorders.

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Hormonal and non-hormonal bases of maternal behavior: The role of experience and epigenetic mechanisms

Cited by 103 publications

References 82 publications

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Pair bond formation leads to a sustained increase in global cerebral glucose metabolism in monogamous male titi monkeys (Callicebus cupreus)

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

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