Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa

Levitan, Robert D.

doi:10.1001/archpsyc.1997.01830180027004

Cited by 58 publications

(30 citation statements)

References 63 publications

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“…The present finding of decreased plasma concentrations of 17ß-estradiol and PRL in bulimic women is in line with previously reported data by both our group and other authors [5,[15][16][17], while the higher plasma levels of cortisol in these patients are consistent with literature data showing an enhanced activity of the hypothalamopituitary-adrenal axis in BN [18,19]. In line with our results, Sundblad et al [20] found increased plasma concentrations of free testosterone in BN women, whereas Raphael et al [21] reported normal blood level of testosterone in 12 bulimic subjects.…”

Section: Discussionsupporting

confidence: 94%

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Cotrufo¹,

Monteleone²,

d’Istria³

et al. 2000

Neuropsychobiology

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Increased aggressiveness frequently occurs in patients with bulimia nervosa (BN), but its neurobiological correlates have been poorly investigated. In this study, we investigated possible relationships between such clinical measure and blood levels of endogenous hormones in patients with BN. Morning plasma levels of testosterone, 17β-estradiol, prolactin (PRL) and cortisol were measured in 33 bulimic women and 22 healthy female controls. The eating-related psychopathology, depression and aggressiveness were rated by specific psychometric scales. Bulimic patients showed decreased plasma levels of PRL and 17β-estradiol, and increased concentrations of cortisol and testosterone. Moreover, patients scored higher than healthy controls on rating scales assessing eating-related psychopathology, depressive symptoms and aggressiveness. A significant positive correlation was found between testosterone plasma levels and aggressiveness in patients but not in controls. These findings suggest that in BN, increased plasma levels of testosterone may play a role in the modulation of aggressiveness.

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Section: Discussionsupporting

confidence: 94%

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Cotrufo¹,

Monteleone²,

d’Istria³

et al. 2000

Neuropsychobiology

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“…Participants rated their mood on the following ten variableshappy, sad, anxious, drowsy, nervous, energetic, calm, fearful, high, and mellow-using visual analog scales (Levitan et al 1997). Each visual analog scale consisted of a 10-cm line with a left border marked "not at all" and a right border marked "most ever".…”

Section: Outline Of the Experimental Proceduresmentioning

confidence: 99%

Levels and circadian rhythmicity of plasma ACTH, cortisol, and β-endorphin as a function of family history of alcoholism

et al. 2005

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“…Active bulimia nervosa (BN) sufferers display altered serotonin (5-hydroxytryptamine (5-HT)) system functioning, as evinced by reduced platelet binding of 5-HT uptake inhibitors (Marazziti et al, 1988;Steiger et al, 2000), reduced central 5-HT transporter availability (Tauscher et al, 2001), blunted neuroendocrine responses to 5-HT precursors and agonists (Levitan et al, 1997;Steiger et al, 2001a, b), and decreased 5-HT metabolites in cerebrospinal fluid (Jimerson et al, 1992). As food restriction is known to alter central 5-HT activity in animals (Huether et al, 1997;Zhou et al, 1996) and in humans (Goodwin et al, 1987), abnormal 5-HT function in BN could, reasonably, be a consequence of disordered eating.…”

Section: Introductionmentioning

confidence: 99%

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

Steiger

Richardson

Israël

et al. 2005

Neuropsychopharmacol

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Findings show brain serotonin (5-hydroxytryptamine (5-HT)) activity to be altered in individuals who have had bulimia nervosa (BN), even after substantial remission of symptoms. Such findings could reflect persistent sequelae due to BN, or a vulnerability 'trait' that exists independently of active eating-disorder manifestations. We compared women with full-blown BN (BN; n ¼ 22), BN in remission (BN-R; n ¼ 11), and no eating or psychiatric disturbances (n ¼ 22) on measures of platelet [3 H]paroxetine binding, eating symptoms and psychopathology. The BN-R group showed normal-range scores on eating and psychopathological symptoms, but reductions in density (B max ) of binding sites for paroxetine similar to those obtained in the actively ill women. Both BN groups had substantially lower B max than did healthy controls. Our results corroborate other findings indicating recovered BN patients to have anomalous 5-HT functioning. While such effects could represent a lasting 'injury' to the system, reported covariations between personality traits and 5-HT indices in BN encourage us to favor the argument that some alterations of 5-HT activity (in this case, consistent with reduced transporter activity) represent a 'trait' associated with the risk of developing BN and/or associated psychopathology.

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Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa

Abstract: Evidence of dysfunction at or downstream of central serotonergic receptors in BN confirms and extends findings of prior research.

Cited by 58 publications

References 63 publications

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Levels and circadian rhythmicity of plasma ACTH, cortisol, and β-endorphin as a function of family history of alcoholism

Reduced Density of Platelet-Binding Sites for [3H]Paroxetine in Remitted Bulimic Women

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