Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole

Górski, J; Taylor, Jolyn; Zhang, Jing; Liu, Jinsong; Jazaeri, Amir A.

doi:10.1016/j.gore.2017.03.005

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…However, the International Menopause Society statement does not mention whether ependymoma is a contradiction for hormone replacement therapy or not 10. Strong positive staining results were observed for ER and PR receptors, in reported cases 4,9. Our patient was administered hormone replacement therapy because of serious peri-menopausal syndrome, and her staining results revealed slightly positive ER and moderately positive PR receptors.…”

Section: Discussionmentioning

confidence: 72%

“…Consequently, authors suggested that ER replacement therapy after castration stimulates viable malignant ependymal cells to proliferate, and that antiestrogens such as tamoxifen can be used postoperatively 8. Furthermore, some studies have demonstrated antiestrogens’ role in the treatment of ovarian or pelvic ependymoma 4,9. However, the International Menopause Society statement does not mention whether ependymoma is a contradiction for hormone replacement therapy or not 10.…”

Section: Discussionmentioning

confidence: 99%

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Individualized treatment for a case of recurrent ovarian ependymoma

Yuan

Chen

2018

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Ovarian anaplastic ependymoma is a rare gynecologic malignancy. Owing to its rarity, treatment is challenging. Unilateral ovarian ependymoma was found during laparoscopy in a 19-year-old woman. After cytoreductive surgery, three cycles of bleomycin, etoposide, and cisplatin were administered. Four years after chemotherapy, the patient experienced relapse. After the secondary cytoreductive surgery, no further treatment was performed. She is in good condition, ~19 months after secondary cytoreductive surgery using hormone-replacement therapy without chemotherapy. Some cases of ovarian ependymoma can be treated with surgery alone without chemotherapy and the outcome has been satisfying. Choosing treatment based on malignant ovarian germ cell tumors may be not optimal. Therefore, we suggest individualized treatment for ovarian ependymoma.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Individualized treatment for a case of recurrent ovarian ependymoma

Yuan

Chen

2018

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“…[1] Positivity for both ER and PR enables treatment with hormonal therapies such as aromatase inhibitors. [11] Our patient received hormonal therapy and has disease-free survival at 8 months postoperatively.…”

Section: Figure 2: (A) True Ependymal Rosette (H and E ×40) (B) Tumor Cells With Fibrillary Processes Inset: "Salt-pepper" Nuclear Chromamentioning

confidence: 82%

Primary ependymoma of the ovary mimicking as yolk sac tumor: A rare case report

Patel

Samanta

Jana

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Ependymoma is a glioma with the differentiation toward ependymal cells that usually arise in the central nervous system. Primary ovarian ependymoma is a rare gynecologic malignancy, of which very few cases have been published. Here, we present the case of a 21-year-old woman who presented with a pelvic mass. Ultrasonography revealed a solid cystic mass in the left adnexa. The patient underwent left oophorectomy followed by cytoreductive completion surgery. On histopathological examination, a possibility of primary glial and neuronal tumor of the ovary was made. The final diagnosis of primary ependymoma of the ovary was arrived upon due to strong positivity for glial fibrillary acidic protein and S100, along with positivity for pancytokeratin, epithelial membrane antigen, vimentin, estrogen receptor, and progesterone receptor on immunohistochemistry. Although a rare diagnosis, when presented with an ovarian mass in a young patient, this diagnosis must be borne in mind.

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“…Gorski et al reported a patient with advanced ovarian ependymoma who underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with BEP, which resulted in a partial response. Due to extensive residual tumour tissues, the patient was maintained on anastrozole for over fifteen months without increased tumour burden [ 16 ]. Hence, high levels of oestrogen during pregnancy may stimulate viable malignant ependymal cells to proliferate.…”

Section: Discussionmentioning

confidence: 99%

Ovarian ependymoma presenting in pregnancy: a case report and literature review

Jin

Jiang

Peng

2020

BMC Pregnancy Childbirth

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Background Ovarian ependymoma is a rare malignancy. Because of the extreme rarity, certain features of the neoplasm, including its clinical behaviour and optimal therapy, are incompletely characterized. Case presentation A 32-year-old pregnant woman at term presented with a left ovarian neoplasm that occurred in the early stage of pregnancy. She underwent left adnexectomy during the caesarean section, and the neoplasm was histologically and immunohistochemically identified to be ovarian ependymoma. Immunohistochemical staining with oestrogen receptors and progesterone receptors showed strong positive staining. According to reports in the literature, the pathological type of ovarian ependymoma in our patient was the extra-axial type. Interestingly, the foetus was also found to have bilateral ependymal cysts during pregnancy. The patient received no further surgical treatment or adjuvant therapy. She and her 14-month-old baby both have no evidence of disease at present. The follow-up of both mother and child is still continuing. Conclusions The case presented here illustrates high levels of oestrogen during pregnancy may stimulate viable malignant ependymal cells to proliferate. Hence, young women with extra-axial-type ependymomas may not be suitable for fertility preservation. Moreover, hormone-based therapies can be a potentially effective treatment for women with extra-axial ependymomas.

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Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole

Cited by 6 publications

References 10 publications

Individualized treatment for a case of recurrent ovarian ependymoma

Individualized treatment for a case of recurrent ovarian ependymoma

Primary ependymoma of the ovary mimicking as yolk sac tumor: A rare case report

Ovarian ependymoma presenting in pregnancy: a case report and literature review

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