Hormonal Contraception

Wiegratz, Inka; Thaler, Christian J.

doi:10.3238/arztebl.2011.0495

Cited by 21 publications

(7 citation statements)

References 119 publications

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“…Oral contraceptives may modify the androgenic effect and thus influence both the prevalence and severity of acne [ 36 , 37 ]. Whereas 55% of adolescents aged 14–19 years [ 38 ] and one third of all fertile women in Germany use oral contraceptives, the percentage of MRKH patients taking oral contraceptives is very low, this being due to infertility. In view of this, one would have expected acne to be even more prevalent among the adolescents with MRKH as oral contraceptives are effective in treating acne and can be considered a preventive treatment.…”

Section: Discussionmentioning

confidence: 99%

Acne and PCOS are less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study

Rall

Conzelmann

Schäffeler³

et al. 2014

Reprod Biol Endocrinol

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BackgroundAcne is a very common skin condition during adolescence and adulthood. Patients with uterovaginal agenesis (Mayer-Rokitansky-Küster-Hauser syndrome, MRKH) treated at the Tübingen University Center for Rare Female Genital Malformations, however, clinically appeared to be less frequently affected by acne. The etiology of MRKH syndrome remains unknown. The only known MRKH-associated mutations are located within the WNT4 gene and lead to an atypical form of MRKH syndrome associated with clinical and biochemical hyperandrogenism. Our study aimed to assess the frequency, severity, and self-evaluation of acne in MRKH patients and to correlate the clinical findings with hormone analyses.MethodsAs part of a cross-sectional longterm follow-up study after laparoscopic assisted creation of a neovagina a questionnaire was sent to 149 MRKH patients aged 16–44 years comprising 26 items concerning prevalence and self-evaluation of acne, and the effects of acne on quality of life. The questionnaire was derived from one used in a former epidemiological study of acne in 4,000 women. Blood for hormone analyses was collected routinely during the clinical visit.ResultsFully completed, evaluable questionnaires were returned by 69/149 (46%) women. Of these respondents, 42 (60.1%) showed hyperandrogenemia without other clinical signs of virilization but only 17 (24.6%) reported acne (8 (11.6%) had physiological acne and 9 (13.0%) clinical acne) and only 10 (14.5%) reported receiving medical treatment for their acne. Effects of acne on quality of life were minor. Only 4 patients (5.8%) with PCOS were identified, among them one with physiological acne, the other three within the acne-free group.ConclusionsAlthough hyperandrogenemia is common, acne is significantly less frequent in women with MRKH than reported in the literature for non-MRKH women, and is seldom treated medically. Patients in this study appeared resistant to acne to some extent, possibly due to the sebaceous glands in the acne regions being less sensitive to androgens compared to the normal population. A WNT4 mutation is unlikely to be the main cause of MRKH syndrome in our hyperandrogenemic patients.

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Section: Discussionmentioning

confidence: 99%

Acne and PCOS are less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study

Rall

Conzelmann

Schäffeler³

et al. 2014

Reprod Biol Endocrinol

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“…Weiterhin sollte bei der Verhütungsberatung das erhöhte karzinogene Risiko thematisiert werden. Untersuchungen zeigen einen leichten Anstieg der Inzidenz für Gebärmutterhalskrebs bei HPV-positiven Patientinnen und hormoneller Verhütung [19]. Daher müssen auch bei Jugendlichen, nach der Kohabitarche, jährliche gynäkologische Vorsorgeuntersuchungen mit Entnahme des zytologischen Abstriches durchgeführt werden [20].…”

Section: Bedürfnisorientierte Verhütungsberatungunclassified

“…Daher müssen auch bei Jugendlichen, nach der Kohabitarche, jährliche gynäkologische Vorsorgeuntersuchungen mit Entnahme des zytologischen Abstriches durchgeführt werden [20]. Gleichzeitig sind durch die Einnahme hormoneller Kontrazeptiva eine bis zu 50-prozentige Risikoreduktion für ein Endometrium-und Ovarialkarzinom sowie eine bis zu 30-prozentige Reduktion für eine kolorektale Krebserkrankung beschrieben [19].…”

Section: Bedürfnisorientierte Verhütungsberatungunclassified

Kein Sex ist auch keine Lösung

Dathan-Stumpf,

Stark

2023

Kinder- und Jugendmedizin

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ZUSAMMENFASSUNGDie Verhütungsberatung von Jugendlichen stellt für Kinder- und Frauenärzte eine besondere Herausforderung dar. Entscheidend für die Zufriedenheit und letztlich auch zuverlässige Anwendung sind die selbstbestimmte Wahl des Kontrazeptivums nach einer bedürfnisorientierten Beratung, bei der auf die Ängste und Sorgen der Mädchen eingegangen wird. Aufgrund der Vielzahl der heute zur Verfügung stehenden Verhütungsmethoden, sollten die Vor- und Nachteile gründlich diskutiert werden. Zu den Kontrazeptiva der ersten Wahl in der Adoleszenz zählen die kombinierten oralen Kontrazeptiva in Form der Pille oder des Vaginalringes, bei Kontraindikation für eine Östrogengabe die Gestagenpille. Als weitere Optionen gelten intrauterine Kontrazeptiva (hormonhaltig, hormonfrei) und das Verhütungsstäbchen. Außerdem müssen Jugendliche explizit auf die additive Verwendung eines Kondoms in Hinblick auf die Vermeidung sexuell übertragbarer Erkrankungen hingewiesen werden.

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“…Various synthetic progestin that are used as contraceptives have been reported to influence lipid profile [ 8 ]. Lipid profile abnormalities as a result of hormonal contraceptives use was associated with some adverse effects including increase in serum glucose, body weight, blood pressure and atherosclerosis [ 9 ]. It is now generally accepted that elevated levels of non-high density lipoprotein-c (HDL-c) and low HDL-c concentrations may promote the development of atherosclerosis that may influence the development of cardiovascular disease (CVD) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of hormonal contraceptives on lipid profile among women attending family planning unit in Goba Town Public Health Facilities, Bale, Southeast Ethiopia: a comparative cross-sectional study

Turki,

Ayalew,

Mossie

et al. 2023

Reprod Health

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Background Hormonal contraceptives are a widely used contraceptive method for the prevention of pregnancy in women. It is associated with change in lipid profile which results in congestive heart failure, coronary heart disease, angina, deep vein thrombosis and stroke which are the major cause of premature death. We aim to investigate the effects of hormonal contraceptive use on lipid profile among women attending family planning unit in Goba Town Public Health Facilities. Methods A comparative cross-sectional study design was conducted on 93 hormonal contraceptive users and 93 non-users’ women in Goba Town Public Health Facilities from September to November, 2022. Blood samples for the estimation of TC, TG, HDL-c and LDL-c levels were collected. Student's independent t-test was used to compare the results of lipid profiles. One-way ANOVA was used to identify the variation of lipid profile between progestin only pills, DMPA and implant users. Simple linear regression was used to determine the change in lipid profiles in relation to the duration of hormonal contraceptive use. P-value less than 0.05 was considered as statistically significant. Result The mean serum level of TC, TG and LDL-c was significantly increases in hormonal contraceptive users in comparison with non-users. The mean serum level TC, TG, LDL-c and HDL-c was significantly different between DMPA, implanon and POP users. The mean serum level of TC, TG and LDL-c in implanon users was lower than DMPA and POP users. As the duration of DMPA and POP use increases, the serum level of TC, TG and LDL-c were significantly increased. But, the serum level of HDL-c was significantly decreased. LDL-c was significantly increased with the duration of implanon use. Conclusion The mean serum level of TC, TG and LDL-c were significantly increased among hormonal contraceptive users. The mean serum level of lipid profile was significantly different between DMPA, implanon and POP users. The serum level of TC, TG, LDL-c were directly proportional to the duration of DMPA and POP use. Routine evaluation of lipid profiles is advisable before and after initiation of hormonal contraceptives.

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Hormonal Contraception

Abstract: As long as personal and familial risk factors are carefully considered, COCs constitute a safe, reversible, and well-tolerated method of contraception.

Cited by 21 publications

References 119 publications

Acne and PCOS are less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study

Acne and PCOS are less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study

Kein Sex ist auch keine Lösung

Effects of hormonal contraceptives on lipid profile among women attending family planning unit in Goba Town Public Health Facilities, Bale, Southeast Ethiopia: a comparative cross-sectional study

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