Hormonal Contraception and Magnesium Deficiency: A Subanalysis of the Magyn Study

Блинов, Д. В.; Ushakova, T. I.; Makatsariya, N. A.; Khamani, N. M.; Bitsadze, V. O.; Dadak, Ch.

doi:10.17749/2313-7347.2017.11.1.036-048

Cited by 10 publications

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“…Так, из нескольких рассмотренных примеров для регистра 6 Приказ Минздравсоцразвития России от 28.02.2011 № 158н «Об утверждении Правил ОМС». 7 Приказ Федерального фонда ОМС от 07.04.2011 № 79 «Об утверждении Общих принципов построения и функционирования информационных систем и порядка информационного взаимодействия в сфере ОМС». больных сахарным диабетом имеет значение тип диабета, который не указывается в реестрах счетов, а для регистра пациентов с ревматоидным артритом имеет значение ортопедо-хирургическое лечение, которое также не выделяется в реестрах счетов отдельно (как еще недавно не выделялась в явном виде и, например, лучевая терапия в онкологии).…”

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“…Другая разновидность регистров представляет собой сбор информации о пациентах с определенной терапией (т. н. экспозиционные регистры препаратов или медицинского оборудования, англ. -product registries) [6][7][8].…”

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Patient registers and account registries of compulsory medical insurance: integration and replaceability

2019

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Калькулятор прямых медицинских расходов, связанных с применением энзалутамида и абиратерона у больных метастатическим кастрационно-резистентным раком предстательной железы, ранее не получавших химиотерапию Моделирование влияния ферментозаместительной терапии на развитие жизнеугрожающих исходов у пациентов с болезнью Фабри Том 11 2018 FARMAKOEKONOMIKA Modern Pharmacoeconomic and Pharmacoepidemiology 2018 Vol. 11 No4 www.pharmacoeconomics.ru ISSN 2070-4909 (print) ISSN 2070-4933 (online) Данная интернет-версия статьи была скачана с сайта http://www.pharmacoeconomics.ru. Не предназначено для использования в коммерческих целях. Информацию о репринтах можно получить в редакции. Тел.: +7 (495) 649-54-95;эл. почта: info@irbis-1.ru.

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Patient registers and account registries of compulsory medical insurance: integration and replaceability

2019

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Medical rehabilitation of patients with menopausal syndrome and surgical menopause: contribution of magnesium deficiency correction

et al. 2023

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Background. The increase in the proportion of patients with menopausal syndrome (MS) and surgical menopause, including women in the recovery phase after radical surgical treatment of the reproductive system cancer, is a characteristic trend of the 21st century. Part of them receive menopausal hormone therapy (MHT). This determines the relevance of the analysis of the specified cohort of patients to enhance rehabilitation programs designed to improve the quality of life (QoL) in this category of gynecological patients.Objective: subanalysis of primary data from the MAGYN study cohort of MHT treated women with MS and surgical menopause.Material and methods. The MAGYN observational non-interventional study of the real clinical practice included 9168 women, of whom 1528 represented a group of previously not characterized MHT treated women with MS and surgical menopause. To determine the number of patients with magnesium deficiency (MD), a Magnesium Deficiency Questionnaire (MDQ) was used, a biochemical blood test with an indicator of serum magnesium concentration was evaluated. The profile of the participants was analyzed by the presence of general somatic pathologies, obstetric, gynecological history, complaints, symptoms of MD on a visual-analog scale. The QoL was assessed with the help of The World Health Organization Quality of Life Brief Version (WHOQOL-BREF) before the start of a 4-week course of MD supplementation and after treatment.Results. According to the MDQ results, the prevalence of DM was 79.4%, which exceeded the results of all other groups in the study. Women with MD had a higher incidence of viral infections (19.2% vs. 22.7%; p=0.028), vegetative-vascular dystonia (26.2% vs. 29.7%; p=0.0466) and osteochondrosis (42.9% vs. 46.8%; p=0.0453). A subgroup of participants with verified MD demonstrated significantly more pronounced symptoms, such as irritability (4.9±3.5 vs. 4.6±3.4 points in the general group; p=0.0437), sleep disorders (4.4±2.3 vs. 4.2±2.3 points; p=0.0491), back pain (3.9±2.0 vs. 3.7±2.0; p=0.0405), and increased fatigue (4.6±2.3 vs. 4.4±2.3 points; p=0.0444). After the end of the course of therapy with fixed dose combination of magnesium citrate and pyridoxine, the sum of MDQ scores decreased from 46.0±12.7 to 29.2±15.1 points (p<0.001) in combination with an increase in the plasma concentration of magnesium to 0.79±0.23 mmol/l; women's satisfaction with their physical, psychological, social well-being increased (from 21.1±4.5 to 26.2±3.5 points; from 24.8±4.9 to 28.1±4.4 points, and from 9.3±2.7 to 11.0±2.8 points, respectively; p<0.001); self-perception increased from 18.2±3.7 to 22.2±3.6 points. Thus, there was a significant decrease in the severity of MD and a significant improvement in QoL according to WHOQOL-BREF, which is important in the rehabilitation of such patients.Conclusion. The profile of patients with MS and surgical menopause receiving MHT, including the period of recovery after radical surgical treatment of reproductive cancer, is characterized by MD and decreased QoL. It seems effective to introduce MD correction into the complex rehabilitation program of such patients. It is necessary to conduct further studies to improve the rehabilitation measures in this cohort of patients.

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Restrictions on the use of valproate in female patients of reproductive age: the updated recommendations based on recent clinical data

Блинов¹,

Avakyan

Акарачкова³

et al. 2019

Èpilepsiâ paroksizmalʹnye sostoâ.

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Hormonal Contraception and Magnesium Deficiency: A Subanalysis of the Magyn Study

Cited by 10 publications

References 0 publications

Patient registers and account registries of compulsory medical insurance: integration and replaceability

Patient registers and account registries of compulsory medical insurance: integration and replaceability

Medical rehabilitation of patients with menopausal syndrome and surgical menopause: contribution of magnesium deficiency correction

Restrictions on the use of valproate in female patients of reproductive age: the updated recommendations based on recent clinical data

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