Hormonal contraceptives and the risk of suicide: a systematic review and meta-analysis

Pérez‐López, Faustino R.; Pérez-Roncero, Gonzalo; López‐Baena, María T.; Santabárbara, Javier; Chedraui, Peter

doi:10.1016/j.ejogrb.2020.04.053

Cited by 10 publications

(22 citation statements)

References 45 publications

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“…Of those, 102 articles (32.8%) were eligible for preliminary data extraction (eFigure 1 in the Supplement ). After the selection criteria for the overlapping meta-analyses were applied ( Table 2 ), 58 articles 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , …”

Section: Resultsmentioning

confidence: 99%

“…Forty-five eligible meta-analyses 25 , 28 , 29 , 30 , 31 , 33 , 34 , 38 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 75 , 76 , 77 , 78 , 79 described 96 potential associations, including 171 individual study estimates of adverse health outcomes associated with hormonal contraceptive exposure. The median number of studies per meta-analysis was 3 (IQR, 2-5), and the follow-up duration ranged from 3 months to 42 years.…”

Section: Resultsmentioning

confidence: 99%

“…Analysis of the methodological quality of 45 meta-analyses 25 , 28 , 29 , 30 , 31 , 33 , 34 , 38 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 75 , 76 , 77 , 78 , 79 using the AMSTAR-2 tool revealed that 6 meta-analyses 41 , 57 , 62 , 66 , 68 , 77 (13.3%) were of high quality, 14 meta-analyses 40 , 44 , 46 , 49 , 50 , 52 ...…”

Section: Resultsmentioning

confidence: 99%

“…Forty 25 , 28 , 31 , 33 , 38 , 40 , 43 , 44 , 45 , 46 , 47 , 49 , 50 , 52 , 54 , 59 , 61 , 62 , 64 , 65 , 66 , 69 , 70 , 71 , 76 , 78 of the 96 examined associations (41.7%) were nominally statistically significant ( P ≤ .05), and only 4 associations 44 , 46 , 65 , 78 (4.2%) reached high significance with a P value of 1.00 × 10 −6 or less ( Table 3 ). Thirty-eight associations 25 , 28 , 29 , 31 , 33 , 38 , 40 , 41 , 44 , 47 , 48 , 49 , 51 , 52 , 53 , 57 , 59 , 60 , 62 , 64 , 65 , 67 , 69 , 72 ,…”

Section: Resultsmentioning

confidence: 99%

“…Small-study effects were found for 10 associations 33 , 44 , 49 , 69 (10.4%), and no excess significance bias was observed for any association. Among 40 statistically significant associations, 25 , 28 , 31 , 33 , 38 , 40 , 43 , 44 , 45 , 46 , 47 , 49 , 50 , 52 , 54 , 59 , 61 , 62 , 64 , 65 , 66 , 69 , 70 , 71 , 76 , 78 only 18 associations 25 , 31 , 38 , 44 , 46 , 47 , 49 , 59 , 62 , 64 , 65 , 69 , 70 , 78 (45.0%) passed the credibility ceiling test using a ceiling value of 10%. Summaries of all significant and nonsignificant associations are provided in Table 3 and eTable 8 in the Supplement , respectively.…”

Section: Resultsmentioning

confidence: 99%

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Association of Hormonal Contraceptive Use With Adverse Health Outcomes

et al. 2022

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Key Points Question What are the quality and certainty of evidence for an association between hormonal contraceptive use and the risk of adverse health outcomes in meta-analyses of randomized clinical trials and cohort studies? Findings In this umbrella review of 58 meta-analyses of randomized clinical trials and cohort studies describing 156 associations between hormonal contraceptive use and adverse health outcomes among women, no associations with adverse outcomes, including cardiovascular and cancer risk, were supported by high-quality evidence. However, the association between the use of a levonorgestrel-releasing intrauterine system and reductions in endometrial polyps associated with tamoxifen use was graded as having high-quality evidence. Meaning The results of this umbrella review supported preexisting understandings of the risks and benefits associated with hormonal contraceptive use, suggesting that the associations between hormonal contraceptive use and adverse health outcomes are not supported by high-quality evidence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Association of Hormonal Contraceptive Use With Adverse Health Outcomes

et al. 2022

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Elevated lipid class concentrations in females with anorexia nervosa before and after intensive weight restoration treatment—A lipidomics study

Hussain,

Bilgin,

Carlsson

et al. 2023

Intl J Eating Disorders

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ObjectiveTo study the plasma lipidome of patients with anorexia nervosa (AN) before and after weight restoration treatment and report associations with AN subtypes and oral contraceptive pill (OCP) usage.MethodsQuantitative shotgun lipidomics analysis was used to study plasma lipids of 50 female patients with AN before and after weight restoration treatment and 50 healthy female controls (HC). The AN group was assessed with blood samples and questionnaires before and after weight restoration.ResultsIn total we quantified 260 lipid species representing 26 lipid classes of which 13 lipid class concentrations were elevated in patients with AN at admission compared with HC. Lipid classes remained elevated after weight restoration treatment of 84 days (median; interquartile range 28), and only the concentration of the ceramide lipid class increased between pre‐ and post‐treatment (p = .03), whereas lysophosphatidylcholine (LPC, p = .02), ether‐linked Phosphatidylcholine (LPCO, p = .02), and lysophosphatidylethanolamine (LPE, p = .009) decreased.ConclusionIn AN, 13 out of 26 lipid class concentrations were elevated at admission and remained elevated post‐treatment. Ceramides increased further between pre‐ and post‐weight restoration treatment, which could be related to the rapid weight gain during re‐nutrition. Further research is needed to elucidate the effects of weight restoration treatment on short‐ and long‐term lipid profiles in individuals with AN.Public Significance StatementLipidomics research can increase the understanding of AN, a complex and potentially life‐threatening eating disorder. By analyzing lipids, or fats, in the body, we can identify biological markers that may inform diagnosis and develop more effective treatments. This research can also shed light on the underlying mechanisms of the disorder, leading to a better understanding of the processes involved in eating behavior.

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