Hormonal control of carbohydrate and lipid metabolism and drug induced alterations

Senft, G.

doi:10.1007/bf00537742

Cited by 19 publications

(1 citation statement)

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“…In some preliminary studies, using anaesthetized dogs, we have been able to show a potentiation of the cardiac responses to sympathetic nerve stimulation with theophylline and in this preparation theophylline produced a positive inotropic effect of its own (our unpublished work). Diazoxide, an agent which, like theophylline, inhibits phosphodiesterase (Senft, 1968) but which has no significant positive inotropic effect, did not potentiate the positive inotropic or positive chronotropic responses either to sympathetic nerve stimulation or to injected noradrenaline.…”

Section: Effect Of Theophylline On the Inhibitory Response To Nitroglmentioning

confidence: 86%

The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine

Lévy

Wilkenfeld

1968

British J Pharmacology

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. Dose response curves for noradrenaline were determined before, during and after pretreatment with a variety of agents. The inhibitory response to noradrenaline on the isolated rat uterus was measured according to its ability to inhibit an acetylcholine induced contraction. . Theophylline, an agent that inhibits phosphodiesterase and increases cyclic AMP levels in the rat, potentiated the response to noradrenaline. . Pretreatment with cocaine had no significant effect on the potentiation of the noradrenaline response by theophylline. . Theophylline potentiated the inhibitory response to nitroglycerine. . Pretreatment with nitroglycerine also potentiated the inhibitory response to noradrenaline. . Theophylline appears to produce a potentiation of the inhibitory effect of noradrenaline on the rat uterus by means of a non‐specific mechanism.

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Section: Effect Of Theophylline On the Inhibitory Response To Nitroglmentioning

confidence: 86%