Hormonal control of pancreatic growth during fetal, neonatal and adult life

Morisset, Jean

doi:10.2478/v10039-008-0029-5

Cited by 6 publications

(5 citation statements)

References 144 publications

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“…Nevertheless, since TNF plays a cruciate role in various processes such as organogenesis and initiation of partum of the placenta [28], its expression in fetal tissues is physiological through the mid and late pregnancy [27]. Its concentration could be increased by various pathological factors that also stimulate other Th 1 cytokines, like IL-1 and -6, which may damage fetal and mature organs [27,[29][30][31]. Such mechanism was experimentally confirmed by Bell et al [2].…”

Section: Discussionmentioning

confidence: 99%

“…Other studies, especially multi-generation ones, are required to explain clinical implications of this phenomenon [9,36,37]. An additional evaluation of specific placental hormones and proteins [30,38] will be also desirable for the future human risk assessment [9,30,36,37,39,40]. Histological placental examination seems to be important scientific procedure, especially in cases the organ weight and fetal abnormalities are revealed.…”

Section: Discussionmentioning

confidence: 99%

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Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Burdan

Szumiło²,

Korobowicz-Markiewicz³

et al. 2010

Folia Histochem Cytobiol.

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Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Burdan

Szumiło²,

Korobowicz-Markiewicz³

et al. 2010

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Similarly, in rats, pancreatic growth with age is not altered by a CCK antagonist (161). By contrast the growth of the neonatal pancreas can be increased by glucocorticoids and thyroxine which probably reflects a role of these hormones on development (90). The human pancreas also shows a linear relationship between size and age from birth to 25 years after which there is little change in size in adults until it begins declining around age 60 (119).…”

Section: Postnatal Pancreatic Growthmentioning

confidence: 93%

“…The effects of gastrin on pancreatic growth has been studied, but no consistent effect has emerged (90,102,135). Secretin by itself has no effect but may potentiate the action of CCK.…”

Section: Models For Studying Adaptive Growth Exogenous Secretagogue Stimulationmentioning

confidence: 99%

Regulation of Normal and Adaptive Pancreatic Growth

Williams¹

Pancreapedia: Exocrine Pancreas Knowledge Base

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“…By contrast the growth of the neonatal pancreas can be increased by glucocorticoids and thyroxine which probably reflects a role of these hormones on development (90). The human pancreas also shows a linear relationship between size and age from birth to 25 years after which there is little change in size in adults until it begins declining around age 60 (119).…”

Section: Postnatal Pancreatic Growthmentioning

confidence: 94%

Regulation of Normal and Adaptive Pancreatic Growth

Williams¹

Pancreapedia: Exocrine Pancreas Knowledge Base

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Hormonal control of pancreatic growth during fetal, neonatal and adult life

Cited by 6 publications

References 144 publications

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Regulation of Normal and Adaptive Pancreatic Growth

Regulation of Normal and Adaptive Pancreatic Growth

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