Hormonal control of sphincter of Oddi

Sarles, J C

doi:10.1007/bf01300710

Cited by 29 publications

(13 citation statements)

References 29 publications

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“…Intravenous injection of caerulein or CCK with bolus produced the relaxation of the SO (Lin and Spray, 1969 ;Carrazziari et al , 1975;Sarles, 1986;Ryan, 1987) which is mediated by nonadrenergic noncholinergic inhibitory motor neurons in the enteric plexus in the dog (Mizutani et al , 1978) and cat (Behar and Biancani, 1980). It is supposed that the reversed response in the gastrectomized dog was produced by direct action on the SO muscles or by indirect action on the intrinsic cholinergic neurons.…”

Section: Discussionmentioning

confidence: 99%

“…Caerulein induced the SO contraction by stimulating the CCK receptors on the smooth muscles of the SO in the dog and cat after application of TTX (Sarles, 1986;Lin, 1975;Bertaccini et al , 1968). The excitatory response was induced by stimulation of the cholinergic neurons in the myenteric plexus of the guinea-pig ileum (Nemeth et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that caerulein and cholecystokinin (CCK) induced a relaxation of the sphincter of Oddi (SO) in humans (Liedberg and Halabi 1970;Carrtu et al, 1975;Corrazziari et al, 1982;Ryan 1987), dogs (Lin and Spray 1969;Mizutani et al, 1978;Sarles 1986), and cats (Behar and Biancani 1980;Sarles 1986) and an excitatory response in dogs (Mizutani et al, 1978) and cats (Behar and Biancani 1980). The relaxation response of the SO to caerulein was induced via nonadrenergic noncholinergic inhibitory neurons in the intrinsic nervous system, and the excitatory response was induced by the direct action on the smooth muscle of the SO (Mizutani et al, 1978;Behar and Biancani 1980).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

Kobayashi¹,

Hosoba²,

Mori³

et al. 1994

J. Smooth Muscle Res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

Kobayashi¹,

Hosoba²,

Mori³

et al. 1994

J. Smooth Muscle Res.

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“…The function of the sphincter is regulated by a complex system that involves many hormonal and neural factors (Sarles 1986, Grace et al 1990, Woods and Saccone 2007. As already mentioned, the literature in the field contains detailed data on the morphology of the SO in a number of mammalian species.…”

Section: Introductionmentioning

confidence: 99%

The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

Tomaszewska¹,

Kaleczyc²

2013

Polish Journal of Veterinary Sciences

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The major duodenal papilla (papilla of Vater) is an important structure associated with the biliary tract and, in some species, the pancreas. It usually represents a slight elevation on the intestinal mucosa where the dilated junction (ampulla of Vater) of the commmon bile duct and pancreatic duct enters the duodenum. The ampulla is surrounded by a specifically arranged muscle structure called the sphincter of Oddi (SO) which controls the flow of bile and pancreatic fluid. The function of the sphincter is regulated by a complex system that involves many hormonal and neural factors. The literature in the field contains detailed data on the morphology of the SO in a number of mammalian species. However, the comprehensive information about the anatomy and neurochemistry of the innervation of this structure is very limited. The present review article summarizes the current knowledge on the innervation of the SO in mammals. Special emphasis has been put on the localization and chemical coding of neurons contributing to this nerve supply.

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“…The reaction on the sphincter of Oddi (SO) to CCK is thought to be species dependent. In the cat [2], dog [3], and human [4], CCK causes the SO to relax, which is thought to be mediated via nonadrenergic, noncholinergic (NANC) inhibitory neurons [5]. On the other hand, in animals where the ampulla is well developed, and macroscopically extraduodenal, such as the opossum [6], rabbit [7], prairie dog [8], and guinea pig [9, 10, 11, 12], CCK contracts the SO.…”

Section: Introductionmentioning

confidence: 99%

Continuous Monitoring of Nitric Oxide Release Induced by Cholecystokinin from the Choledochal Sphincter in Guinea Pigs

Shima

Mori²,

Takakura³

et al. 2000

Digestion

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Background/Aims: Many in vitro studies in the choledochoduodenal junction of the guinea pig have shown that cholecystokinin (CCK) contracts the sphincter of Oddi (SO). This study, using the choledochal sphincter of the guinea pig as the SO, evaluates the hypothesis that effects of CCK on the SO were mediated by nitric oxide (NO). Methods: Spontaneous motility and effects of CCK on the choledochal sphincter were recorded using a constant-perfusion technique, and direct measurement of NO release using a specific NO sensor was performed at the same time. Results: CCK-8 decreased the phasic wave amplitude of the choledochal sphincter, and increased NO release. N^G-L-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase, increased the spontaneous motility and converted the CCK-induced inhibitory response into an excitatory response. L-NAME also reduced NO release and abolished the increase of NO that had been caused by CCK-8. These effects were reduced by treatment with L-arginine (L-Arg). L-Arg application enhanced NO release, and recovered the increase of NO by CCK-8. Conclusion: These studies demonstrate that CCK relaxes the choledochal sphincter and this relaxant response is mediated by NO.

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Hormonal control of sphincter of Oddi

Cited by 29 publications

References 29 publications

Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

Continuous Monitoring of Nitric Oxide Release Induced by Cholecystokinin from the Choledochal Sphincter in Guinea Pigs

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