Hormonal Crosstalk Between Thyroid and Breast Cancer

Halada, Stephen; Casado‐Medrano, Victoria; Baran, Julia; Lee, Josh; Chinmay, Poojita; Bauer, Andrew J.; Franco, Aime T.

doi:10.1210/endocr/bqac075

Cited by 19 publications

(10 citation statements)

References 263 publications

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“…The role of estrogen in breast cancer (BC) has been confirmed, and more and more studies have recently confirmed the importance of estrogen in the development of TC [8][9][10]. Studying the molecular mechanism of estrogen in TC, is of great significance for clarifying the sex difference in TC pathogenesis, precision treatment and prognosis of TC [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Wang,

Zhang,

Liang

et al. 2024

Preprint

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BACKGROUND Papillary thyroid cancer (PTC), accounts for approximately 90% of all thyroid cancer cases, the underlying mechanism was unclear. LINC00623 was a new proved epigenetic modification(ac4C) gene. However, the study about the role of LINC00623 in pan cancer and thyroid cancer induced by estradiol (E2) have not yet been explored. METHODS Pan-cancer analysis based on TCGA was carried out by Sanger box. Different gene expressions were analyzed by DESeq2 Package. Receiver-operating characteristic (ROC) curves were used to evaluate the diagnostic value of it for Pan cancer and THCA. Overall survival was calculated by the Kaplan–Meier univariate and cox multivariate analyses. In vitro, after knockdown of LINC00623, MTT/clone formation/Cell cycle and apoptosis were carried out. E2/ Bisphenol (BPA) stimulation and GSK inhibition experiment was carried out. RESULTS LINC00623 play an important role in diagnosis and prognosis in pan cancer and THCA.LINC00623 is an important biological indicator of immune microenvironment and immune infiltrating cells in pan-cancer and THCA. We first verified that E2 and BPA could induce the expression of LINC00623 in PTC cell lines. In vitro experiments verified that LINC00623 significantly affected the biological process of PTC such as proliferation, cycle, and apoptosis. Mechanism exploration identified LINC00623 affected the epigenetics of PTC, namely H3K27me3 and H3K36me3 through PHF19. The LINC00623 promote the progress of BHP10-3 cell acting as an oncogene; LINC00623 knock down increased the H3K27me3 and down regulated the H3K27me3 via PHF19, GSK126 can rescue the cell biological inhibition caused by LINC00623 knock down. Conclusion LINC00623 play a significant role in pan-cancer and thyroid cancer. E2/BPA can induce the expression of LINC00623.LINC00623 was an epigenetic regulator of H3K27me3 and H3K36me3 via PHF19 in PTC. It can be a potential therapy target for PTC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Wang,

Zhang,

Liang

et al. 2024

Preprint

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“…In addition, several mechanistic studies have confirmed the role of oestrogen and its receptors in the promotion of TC 19,20 . Oestrogen and its receptors have previously been extensively studied in breast cancer, but this endocrine fluctuation may also be associated with the thyroid, and studies have now shown a correlation between breast cancer and TC 21,22 …”

Section: Discussionmentioning

confidence: 93%

“…19,20 Oestrogen and its receptors have previously been extensively studied in breast cancer, but this endocrine fluctuation may also be associated with the thyroid, and studies have now shown a correlation between breast cancer and TC. 21,22 Sex differences are a potential influencing factor in prognosis, oestrogen levels in women begin to decline significantly. Therefore, we set the cut-off age of menopause as 50 years in this study, 23,24 which is consistent with the grouping of many studies on perimenopause.…”

Section: Discussionmentioning

confidence: 99%

Age‐dependent changes in the prognostic advantage of papillary thyroid cancer in women: A SEER‐based study

Liu

Song

et al. 2023

Clinical Endocrinology

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Background: Papillary thyroid cancer (PTC) is more prevalent in women, and women show a better prognosis than men; however, the factors contributing to this prognostic difference are confounding. Therefore, we aimed to investigate the effect of the interaction between sex and age on the prognosis of PTC.Methods: A total of 108,459 patients with PTC were retrospectively analysed, and Cox-regression models were used to assess differences in disease specific survival (DSS) by sex, with inverse probability of treatment weighting (IPTW) to control for between-group differences in prognosis by sex due to age change. Restricted cubic splines were used to analyse prognostic differences between sexes for papillary thyroid microcarcinoma (PTMC) and PTC. Multiple mediation analyses were used to assess the direct or indirect effect of sex on DSS. Results:The DSS was higher for women than men (98.6% vs. 95.4%, χ 2 = 458.57, p < .001). After IPTW adjustment, the DSS of women was better than that of men (HR = 0.67, 0.60−0.76). In the subgroup analysis, women had an advantage in DSS across most age intervals (crude HR = 0.166 [0.082−0.337], p < .001, IPTW-adjusted HR = 0.331 [0.161−0.681], p < .001). The difference between the two gradually narrowed with increasing age, and the prognosis of women was better than that of men in PTMC, while this advantage was not obvious in PTC. Conclusions:The overall PTC prognosis of women is better than that of men, but the prognostic advantage of women diminishes with age and tumour growth. These differences in prognosis may be due to some indirect factors caused by different sexes.

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“…We speculate that breast cells are responsive to thyroid hormone signaling and are affected by altered thyroid hormone levels. 16 However, further studies are needed to confirm the relevant mechanism.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Granulomatous Mastitis and Establishment and Validation of a Clinical Prediction Model (Nomogram)

Zeng,

Zhang,

et al. 2023

RMHP

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Background This study aimed to explore the risk factors and clinical characteristics of granulomatous mastitis (GM) using a case-control study and establish and validate a clinical prediction model (nomogram). Methods This retrospective case-control study was conducted in three hospitals in China from June 2017 to December 2021. A total of 1634 GM patients and 186 healthy women during the same period were included and randomly divided into the modeling and validation groups in a 7:3 ratio. To identify the independent risk factors of GM, univariate and multivariate logistic analyses were conducted and used to develop a nomogram. The prediction model was internally and externally validated using the Bootstrap technique and validation cohort. The receiver operating characteristic (ROC) curve and calibration curve were used to evaluate the discrimination and calibration of the prediction model. Decision curve analysis (DCA) and clinical impact curve (CIC) were used to evaluate the clinical significance of the model. Results The average age of GM patients was 33.14 years (mainly 20–40). The incidence was high within five years from delivery and mainly occurred in the unilateral breast. The majority of the patients exhibited local skin alterations, while some also presented with systemic symptoms. On multivariate logistic analysis, age, high prolactin level, sex hormone intake, breast trauma, nipple discharge or invagination, and depression were independent risk factors for GM. The mean area under the curve (AUC) in the modeling and validation groups were 0.899 and 0.889. The internal and external validation demonstrated the model’s predictive ability and clinical value. Conclusion Lactation-related factors are the main risk factors of GM, leading to milk stasis or increased ductal secretion. Meanwhile, hormone disorders could affect the secretion and expansion of mammary ducts. All these factors can obstruct or injure the duct, inducing inflammatory reactions and immune responses. Additionally, blunt trauma, depressed mood, and diet preference can accelerate the process. The nomogram can effectively predict the risk of GM.

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Hormonal Crosstalk Between Thyroid and Breast Cancer

Cited by 19 publications

References 263 publications

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Age‐dependent changes in the prognostic advantage of papillary thyroid cancer in women: A SEER‐based study

Risk Factors for Granulomatous Mastitis and Establishment and Validation of a Clinical Prediction Model (Nomogram)

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