Hormonal Fluctuations Related to Depressive Symptoms in Menopause

Abstract

Depression has a high incidence among perimenopausal women. This systematic review focuses on the connection between hormonal fluctuations and depressive symptoms. The 5% chances of depression are correlated with increasing additional year between menarche and menstrual transition (MT) onset. The higher rates of depressive symptoms were associated with more substantial variation in serum estradiol. Progesterone > 6 ng / dL has been linked with lower rates of depressive symptoms. The results may also indicate an interaction of ovarian hormones, serotonin deficiency and cortisol in this process.