Hormonal interactions in : Effect of hormones on levels of epidermal growth factor (EGF)

Csaba, G.; Kovács, P.; Pállinger, Éva

doi:10.1016/j.cellbi.2005.01.004

Cited by 12 publications

(10 citation statements)

References 28 publications

(30 reference statements)

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“…(LeRoith et al, , 1982serotonin, histamine, melatonin, etc. (LeRoith et al, , 1983Csaba, 2000;KThidai et al, 2003), and there is an interaction between these molecules (Csaba et al, 2005). As the hormones mentioned influence the physiological reactions of Tetrahymena and allow to obtain an insight into the phylogeny of endocrine system, their quantitative determination and exact localization seems to be important.…”

Section: Introductionmentioning

confidence: 99%

EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis

Csaba¹,

Kovács²,

Pállinger³

2006

Cell Biology International

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Earlier experiments demonstrated the presence of hormones of the higher ranked animals in Tetrahymena. In the present experiments two fixatives, paraformaldehyde, which is commonly used and a carbodiimide, EDAC that was recommended by Panula et al. for the immunocytochemistry of histamine, are compared in Tetrahymena for the demonstration of histamine and serotonin by using flow cytometry and confocal microscopy. Both hormone levels were significantly higher after EDAC fixation; serotonin almost doubled and histamine was more than fivefold. The confocal microscopic pictures were clearer and the hormones' localization was easier. The results support earlier observations on the presence of these hormones in Tetrahymena and points to the advantage of EDAC fixation for demonstrating these hormones immunocytochemically.

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Section: Introductionmentioning

confidence: 99%

EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis

Csaba¹,

Kovács²,

Pállinger³

2006

Cell Biology International

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“…49,50 The hormones also can influence the production of each other, which points to a hormonal network inside the Tetrahymena population. [49][50][51][52] This means that not only the basis of the receptor-hormone relation is present at this low level of phylogeny, but also the basis is present of the complete endocrine system which is destined for remote-commanding cells and co-ordinating their function in multicellular animals. The unicellular Tetrahymena is an indiviual organism but the Tetrahymena population of a given area can behave as cells of an organism and can be co-ordinated by the hormones produced, stored, secreted and recognized by their elements.…”

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confidence: 99%

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

Csaba

2007

Cell Biochemistry & Function

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Hormonal (chemical) imprinting which was first observed (and named) by us in the seventies of the last century, is a general biological phenomenon which takes place when the developing receptor meets its target hormone for the first time. Under the effect of imprinting, receptors mature and reach their maximal binding capacity. It also influences the cells' hormone production and different functions depending on receptors and hormones. Hormonal imprinting is present already at the unicellular level causing the development of specific receptors and helping the easier recognition of useful or harmful surrounding molecules. The phenomenon is an important factor in the survival of the species, as the effect of imprinting is transmitted to the progeny cell generations. At the same time it possibly helps the selection of molecules which are suitable for acting as hormones in higher ranked animals. In mammals, hormonal imprinting takes place perinatally and determines the function of receptor-signal-transduction systems as well as hormone production for life. However, there are other critical imprinting periods for continuously developing cells. Excess of the target hormones or presence of foreign molecules which are able to bind to the receptors, provoke faulty imprinting in the critical periods with life-long morphological, biochemical, functional or behavioural consequences. As many receptor-bound foreign molecules are used as medical treatments and many such molecules are present around us and inside us as environmental pollutants, they--causing faulty imprinting--are able to predispose the (human) organism to cardiovascular, endocrine, metabolic and cancerous diseases. It seems likely that this effect is connected with disturbance of DNA methylation process in the critical periods of life. There are some signs of the transgenerational effect of faulty imprinting and this could be manifested in the evolution of humans by an epigenetic route.

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“…A possible explanation is given by the interhormone relationship theory which states that hormones produced by Tetrahymena alter each other's expression [30]. For example, Ser decreases His level while Ser and His enhances EGF production [36], [37]. Another theory stems from the fact that the cholinergic and adrenergic systems are the oldest; therefore, their signal transduction mechanisms are likely to be more developed at this stage of phylogeny.…”

Section: Discussionmentioning

confidence: 99%

The Phylogenetic Background of Neurotransmitters in the Unicellular Organism Tetrahymena Pyriformis

Tziakouri

Lajkó

Kőhidai

2018

ABNE

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The Human Central Nervous System (CNS) is governed by electrochemical networks forming a delicate interplay between the different regions of the brain. The objective of the present experiment is to investigate the phylogenetic background of this electrochemical network by creating a comparable binary and ternary interplay of interactions between different neurotransmitters (noradrenaline, histamine, serotonin, acetylcholine, glutamate, and dopamine) in the unicellular eukaryote Tetrahymena pyriformis. Tetrahymena – as a protozoon – has no nervous system; however, it has been shown that it has not only the ability to store, synthesize and secrete biogenic amines but it also bears binding sites for the corresponding receptors of some of these molecules. The chemotactic responsiveness elicited by the neurotransmitters was examined in Tetrahymena cells, using a modified version of Leick’s two-chamber capillary chemotaxis assay with 20-minute incubation times. The concentration course of each neurotransmitter was determined and the concentration eliciting the strongest effect was further used to examine the chemotactic response of the neurotransmitters when used in pairs and in groups of three. Adequate cellular responses (chemoattractant and chemorepellent) were detected in both cases when the neurotransmitters were used alone and in combinations. A pattern detected in these responses was related to the neurotransmitters’ physicochemical characteristics (XlogP, TPSA). These provide evidence that the chief regulatory molecules of the CNS can be identified even in lower, eukaryotic unicellular levels of phylogeny and possibly alter the basic functions of these organisms. In summary, our results support the theory that any evolved nervous system-like interplay could stem from a common origin. Therefore, identifying the “ancient” function of a molecule or its receptor effect can open new windows in the advancement of therapeutic interventions.

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Hormonal interactions in : Effect of hormones on levels of epidermal growth factor (EGF)

Cited by 12 publications

References 28 publications

EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis

EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

The Phylogenetic Background of Neurotransmitters in the Unicellular Organism Tetrahymena Pyriformis

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