Hormonal Modifiers of Mineral Metabolism Other Than Parathyroid Hormone, Vitamin D, and Calcitonin

Rude, Robert K.; Singer, Frederick R.

doi:10.1016/b978-0-12-135302-5.50015-8

Cited by 2 publications

(1 citation statement)

References 510 publications

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“…Unfortunately, the mechanism through which estrogen affects calcium metabolism has not been clearly established (12,13), but estrogen apparently can modify the actions of hormones that affect calcium metabolism. Some of this modification probably occurs at the cell membrane level.…”

Section: Discussion-human Experiments 1 Andmentioning

confidence: 99%

Biochemical and physiologic consequences of boron deprivation in humans.

Nielsen

1994

Environ Health Perspect

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Boron deprivation experiments with humans have yielded some persuasive findings for the hypothesis that boron is an essential nutrient. In the first nutritional study with humans involving boron, 12 postmenopausal women first were fed a diet that provided 0.25 mg boron/2000 kcal for 119 days, and then were fed the same diet with a boron supplement of 3 mg boron/day for 48 days. The boron supplementation reduced the total plasma concentration of calcium and the urinary excretions of calcium and magnesium, and elevated the serum concentrations of 1 7f,-estradiol and testosterone. This study was followed by one in which five men over the age of 45, four postmenopausal women, and five postmenopausal women on estrogen therapy were fed a boron-low diet (0.23 mg/2000 kcal) for 63 days, then fed the same diet supplemented with 3 mg boron/day for 49 days. The diet was low in magnesium (115 mg/2000 kcal) and marginally adequate in copper (1.6 mg/2000 kcal) throughout the study. This experiment found higher erythrocyte superoxide dismutase, serum enzymatic ceruloplasmin, and plasma copper during boron repletion than boron depletion. The design of the most recent experiment was the same as the second study, except this time the diet was adequate in magnesium and copper. Estrogen therapy increased plasma copper and serum 17p-estradiol concentrations; the increases were depressed by boron deprivation.Estrogen ingestion also increased serum immunoreactive ceruloplasmin and erythrocyte superoxide dismutase; these variables also were higher during boron repletion than depletion for all subjects, not just those ingesting estrogen. Dietary boron had no effect on those variables in the men and women not ingesting estrogen. These findings suggest that boron can both enhance and mimic some effects of estrogen ingestion. The findings from all three studies are consistent with the hypothesis that boron has an essential function that affects macromineral and cellular metabolism at the membrane level. - (701) 795-8395. menopause associated with an increased loss of calcium from bone or the body.Twelve postmenopausal women first were fed a diet that provided 0.25 mg B/2000 kcal for 119 days and then were fed the same diet with a boron supplement of 3 mg/day for 48 days. During the experiment, seven of the women were fed a diet low in magnesium (116 mg/2000 kcal); the other five had their diet supplemented with 200 mg Mg/day. The boron supplementation of the boron-deprived women decreased the urinary excretion and plasma concentration of calcium and magnesium, decreased the urinary excretion and plasma concentration of phosphorus in the women fed the magnesium-low diets, and increased plasma testosterone and 17p-estradiol concentrations. Generally, the effects of boron deprivation, or supplementation, seemed more marked in the women fed the magnesium-low diet.Another study was performed with five men over the age of 45, nine postmenopausal women (five postmenopausal women on estrogen therapy) and one premenopausal woman (originally t...

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Section: Discussion-human Experiments 1 Andmentioning

confidence: 99%

Biochemical and physiologic consequences of boron deprivation in humans.

Nielsen

1994

Environ Health Perspect

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Beta-2-microglobulin in diseases with high bone remodeling

et al. 1995

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Beta2-microglobulin has been observed to behave as a biological marker of bone remodeling. We measured beta2-microglobulin and tartrate-resistant acid phosphatase (TRAP), a specific biological marker of bone remodeling, in 225 women: healthy premenopausal controls, healthy postmenopausal control, and patients with diseases characterized by enhanced bone turnover (postmenopausal osteoporosis, primary hyperparathyroidism, primary hyperthyroidism, polyostotic Paget's bone disease), and in other Paget's group before and after calcitonin treatment. Beta2-microglobulin levels differed significantly between the healthy premenopausal women (n = 20) compared with all the other groups. However, beta2-microglobulin levels did not differ significantly between healthy postmenopausal women (n = 38) and patient's with Paget's bone disease (n = 40)(P = 0.5095), or between women with postmenopausal osteoporosis (n = 30) and women with hyperthyroidism (n = 20)(P = 0.7890). TRAP concentrations differed significantly in all the groups paired except for women with Paget's bone disease and women with either hyperparathyroidism or hyperthyroidism (P = 0.5179 and 0.6993, respectively); likewise, TRAP levels did not differ significantly between the women with hyperparathyroidism and those with hypothyroidism (P = 0.7804). After calcitonin treatment, there was a 22% increase in beta2-microglobulin, a 17% decrease in TRAP, and a 39% decrease in alkaline phosphatase, all of which were significant at P < 0.0001. Our findings indicate that serum beta2-microglobulin, like osteocalcin, behaves as a biological marker of remodeling in a number of diseases with enhanced bone remodeling but not in Paget's bone disease.

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Hormonal Modifiers of Mineral Metabolism Other Than Parathyroid Hormone, Vitamin D, and Calcitonin

Cited by 2 publications

References 510 publications

Biochemical and physiologic consequences of boron deprivation in humans.

Biochemical and physiologic consequences of boron deprivation in humans.

Beta-2-microglobulin in diseases with high bone remodeling

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