Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Andersen, Mônica Levy; Alvarenga, Tathiana A.; Mazzotti, Diego R.; Guindalini, Camila; Pellegrino, Renata; Barrueco, Karina F.; Santos-Silva, Rogério; Bittencourt, Lia; Tufik, Sérgio

doi:10.1016/j.fertnstert.2010.10.012

Cited by 8 publications

(4 citation statements)

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“… Data presented herein refer to values obtained from the sample used in this study. These parameters were also analyzed with different experimental designs in previous studies (Andersen et al ., ,b, ,c). Adjusted mean ± SE of the mean of follicle‐stimulating hormone (FSH, mIU/mL), luteinizing hormone (LH, mIU/mL), progesterone (ng/mL), total testosterone (ng/dL), free testosterone (pg/mL), estradiol (pg/mL) and prolactin (pg/mL) levels with covariates BMI, age, social class, ethnicity, renal disease, diabetes, myocardial infarction and stroke.…”

Section: Resultsmentioning

confidence: 99%

The association between TNF-α and erectile dysfunction complaints

et al. 2013

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SUMMARYInflammatory markers like tumour necrosis factor-alpha (TNF-a) have been related to erectile dysfunction (ED) and may interact with other cardiovascular risk factors such as obstructive sleep apnoea syndrome (OSAS). The aim of this study was to examine the inflammatory, metabolic and hormonal profile of men with or without ED complaints and/or OSAS recruited through the Epidemiologic Sleep Study (EPISONO). A sample of 363 men completed sexual questionnaires for ED and had physical and blood examinations. OSAS was evaluated by polysomnography and clinical assessment. The blood samples were used for determination of TNF-a, interleukin-6, leptin, cholesterol and fractions, triglycerides, homocysteine, glucose and hormonal levels. After controlling for confounding factors, men with ED complaints presented higher systolic blood pressure and TNF-a, independent of OSAS. Significant interaction between ED and OSAS was only observed for neck circumference, which was higher in ED men with OSAS than men with OSAS without ED and men with ED without OSAS. Binary logistic regression showed that the predictor factors for ED were age >43 years, myocardial infarction events, TNF-a and systolic blood pressure. Finally, a receiver-operating characteristics curve suggested a cut-off point of 9.95 pg/mL for TNF-a with sensitivity of 60% and specificity of 59% in men with ED complaints. Furthermore, there was a significant association between high levels of TNF-a (>9.95 pg/mL) and the presence of ED complaints. The results showed that there was an association between TNF-a levels and ED complaints in men independent of OSAS.

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Section: Resultsmentioning

confidence: 99%

The association between TNF-α and erectile dysfunction complaints

et al. 2013

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“…Moreover, PROGINS has been identified as a risk factor for a number of benign and malignant gynecological diseases in women [69–71] and prostate cancer in men, which suggests potential functional properties of this polymorphism [72]. A recent study was the first to evaluate the influence of the PROGINS polymorphism and hormone levels on the risk for ED [73]. Contrary to the hypothesis, hormonal (progesterone, prolactin, testosterone, and estradiol) levels were not significantly different between the genotype groups (T1/T1 and T1/T2 + T2/T2), and no significant differences were found for the genotype or allelic distribution between individuals with ED complaints and controls, which suggests that the PROGINS polymorphism does not have a direct role in the risk of developing ED.…”

Section: Resultsmentioning

confidence: 99%

“…The efficacy rates of drug therapy for most diseases range from 25% to 80% [73], suggesting that individual genetic variations may play an important role in determining individual genetic sensitivity to medications [74,75]. This is the case for a group of phase I cytochrome P450 metabolizing enzymes, which are responsible for catalyzing a variety of oxidation reactions in the large majority of prescribed drugs [76].…”

Section: Resultsmentioning

confidence: 99%

Genetics of Erectile Dysfunction: A Review of the Interface between Sex and Molecular Biomarkers

Andersen

Guindalini

Tufik

2011

The Journal of Sexual Medicine

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Introduction In recent years, new tools for the study of molecular biology and genetics have resulted in significant contributions to the scientific community. The potential use of genetic variations as biomarkers in the management of current and future conditions is generating considerable excitement in health care for disorders such as erectile dysfunction (ED). Aim This review briefly describes the molecular and genetic mechanisms involved in ED and provides an overall view of the literature relevant to possible relationships between genetic factors and ED. Methods This is a narrative review of studies on the potential influence of polymorphisms on the risk of developing ED. Main Outcome Measure We reviewed genetic association studies involving polymorphisms and the ED phenotype. Results There is growing evidence for the influence of genetic polymorphisms on the risk of ED and on the interindividual variability in sildenafil treatment. Conclusions Although this field is still in its infancy, genetic association studies aimed at defining a molecular basis for ED have provided some important evidence that a patient's genotype may be used in the future to assess risk, as well as to plan treatment and prevention programs in the clinic.

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“…However, in the report by Andersen et al there was no difference in the frequency of PROGINS in an ED vs a nonED group. 28 The limitation of the report was that only 1.2% of subjects were homozygous for Alu insertion, possibly making the sample size inadequate to detect a difference.…”

Section: Hormone Receptorsmentioning

confidence: 96%

Genetics of Erectile Dysfunction

Lopushnyan

Chitaley

2012

Journal of Urology

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Studies investigating the genetics of erectile dysfunction are mostly derived from animal models and candidate gene approaches. Candidate gene studies omit the greater portion of the genome, a problem that can be solved using a genome wide association study approach. The lack of persistently replicated results of candidate gene studies may be related to different patient ethnic backgrounds, variations in erectile dysfunction etiology and small sample sizes. Using strict inclusion/exclusion criteria for erectile dysfunction etiology and ethnicity in human studies may lead to improved understanding of the genetics of erectile dysfunction in specific populations.

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Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Cited by 8 publications

References 50 publications

The association between TNF-α and erectile dysfunction complaints

The association between TNF-α and erectile dysfunction complaints

Genetics of Erectile Dysfunction: A Review of the Interface between Sex and Molecular Biomarkers

Genetics of Erectile Dysfunction

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