Hormonal Regulation of Renal Fibrosis

Abramicheva, P A; Plotnikov, Egor Y.

doi:10.3390/life12050737

Cited by 5 publications

(1 citation statement)

References 170 publications

(204 reference statements)

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“…Furthermore, estrogen can be protective during acute infectious processes. In contrast, it has been hypothesized that testosterone has pro-fibrotic and pro-apoptotic properties by promoting the increased activity and sensitivity of renal cells to TNF-α and may worsen the symptoms of an acute inflammatory process due to its immunosuppressive effects, as opposed to females who show a more efficient immune response in the case of severe infections [ 66 , 67 , 68 ]. In a recent study, numbers from the intensive care unit and hospital mortality were comparable between men and women with AKI related to systemic sepsis, evocating the minor role of gender differences in influencing the clinical course of critically ill patients with declines in renal function linked to sepsis [ 69 ].…”

Section: Gender Differences In Kidney Damagementioning

confidence: 99%

Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Ciarambino

Giordano

2022

Cells

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Acute kidney injury (AKI) is a major clinical problem associated with increased morbidity and mortality. Despite intensive research, the clinical outcome remains poor, and apart from supportive therapy, no other specific therapy exists. Furthermore, acute kidney injury increases the risk of developing chronic kidney disease (CKD) and end-stage renal disease. Acute tubular injury accounts for the most common intrinsic cause of AKI. The main site of injury is the proximal tubule due to its high workload and energy demand. Upon injury, an intratubular subpopulation of proximal epithelial cells proliferates and restores the tubular integrity. Nevertheless, despite its strong regenerative capacity, the kidney does not always achieve its former integrity and function and incomplete recovery leads to persistent and progressive CKD. Clinical and experimental data demonstrate sexual differences in renal anatomy, physiology, and susceptibility to renal diseases including but not limited to ischemia-reperfusion injury. Some data suggest the protective role of female sex hormones, whereas others highlight the detrimental effect of male hormones in renal ischemia-reperfusion injury. Although the important role of sex hormones is evident, the exact underlying mechanisms remain to be elucidated. This review focuses on collecting the current knowledge about sexual dimorphism in renal injury and opportunities for therapeutic manipulation, with a focus on resident renal progenitor stem cells as potential novel therapeutic strategies.

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Section: Gender Differences In Kidney Damagementioning

confidence: 99%

Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Ciarambino

Giordano

2022

Cells

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Interaction of estradiol and renin–angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway

Rajabi,

Saberi,

Najafipour

et al. 2024

Mol Biol Rep

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Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study

Liu,

Zhou

et al. 2023

Immunol Res

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Diagnosis of renal fibrosis can only be verified by kidney biopsy, but biomarkers for non-invasive evaluation remain unsatisfactory. Patients with fibrosis often have abnormalities of the lymphatic vascular system and associated immune function. We describe here a lymphatic marker as a candidate biomarker for fibrosis. After assessing and grading the fibrosis scores, testing serum soluble lymphatic vessel endothelial hyaluronan receptor1 (sLYVE1) level, and collecting clinical information, the association between sLYVE1 and renal fibrosis was analyzed. Logistic regression analysis was used to screen variables. Diagnosis models with or without sLYVE1 were built, and nomograms were plotted. Calibration curve, C-index, and DCA were performed to assess the models. A total of 298 patients were enrolled in the study, of which 199 were included in the training cohort and 99 patients in the validation cohort. Serum sLYVE1 levels markedly elevated with increasing fibrosis grade (p<0.05). ROC analysis of sLYVE1 showed an AUC of 0.791 and 0.846 with optimal cut-off value of 405.25 ng/mL and 498.55 ng/mL for the prediction of moderate-to-severe renal fibrosis (MSF) and severe renal fibrosis (SF), respectively. The diagnostic nomogram model without sLYVE1 (model 1) included traditional clinical determinants (C-index: 0.658 for MSF; 0.603 for SF). A combination of model 1 and sLYVE1 (model 2) improved predictive performance (C-index: 0.847 for MSF; 0.856 for SF). Calibration curve and DCA demonstrated a better consistency accuracy and clinical benefit of model 2 than model 1. Serum sLYVE1 may be identified as a potential biomarker of renal fibrosis. Models incorporating sLYVE1 may be beneficial for a more accurate non-invasive diagnosis of renal fibrosis.

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Hormonal Regulation of Renal Fibrosis

Cited by 5 publications

References 170 publications

Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Interaction of estradiol and renin–angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway

Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study

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