Hormonal regulation of spermatogenesis through Sertoli cells by androgens and estrogens

Smith, Lee B.; Walker, William H.; O’Donnell, Liza

doi:10.1016/b978-0-12-417047-6.00006-5

Cited by 8 publications

(7 citation statements)

References 145 publications

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“…The low FSH concentration recorded in the CPF-treated group in the present study was following the report [31]. The lower FSH concentration may be correlated to the low sperm count in the CPF group because the FSH is greatly involved in spermatogenesis [41]. The influence of CPF on the FSH and LH levels may be attributed to its ability to downregulate the genes involved in gonadotropin synthesis and/or inhibition of steroidogenesis [42].…”

Section: Discussionsupporting

confidence: 75%

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The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats

Khalaf

Ogaly

Ibrahim

et al. 2021

Biol Trace Elem Res

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The current study aimed to evaluate the harmful effect of chlorpyrifos (CPF) on the reproductive functions and fertility in male rats and to assess the protective role of zinc (Zn) in improving the adverse effects of CPF on male fertility. Sixty mature male rats were divided into four groups: Group 1: The control group was orally administered with the corresponding dose of corn oil. Group 2 animals received chlorpyrifos (1 mg/kg, oral). Group 3 rats received oral zinc (25 mg/kg) daily. Group 4 animals received oral zinc treatment (25 mg/kg). CPF caused a significant decrease in the body and reproductive organs' weights, sperm count, sperm motility percent, serum testosterone, FSH, and LH. The CPF-treated group showed a significant increase in dead sperm percent and sperm abnormalities. CPF induced a significant internucleosomal DNA fragmentation and marked histological alterations in the testes of treated male rats. Conversely, co-treatment with Zn improved the reproductive organs weights, sperm characteristics, internucleosomal DNA fragmentation, and histological alterations of the testes. In conclusion, CPF triggered significant detrimental effects on male reproductive organs and functions and the co-treatment with zinc partly alleviate the injurious effects of CPF on male fertility.

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Section: Discussionsupporting

confidence: 75%

“…The reduction in testosterone level might be attributed to the decrease in serum LH. This is because LH regulates the secretion of testosterone by the testicular Leydig cells [41].…”

Section: Discussionmentioning

confidence: 99%

The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats

Khalaf

Ogaly

Ibrahim

et al. 2021

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…A decline in serum LH might be due to decreased testosterone levels. LH is involved in spermatogenesis by targeting testicular Leydig cells to inhibit testosterone synthesis [ 33 , 42 ]. Furthermore, active sulfur atoms, CPF metabolites, inhibit activation of cytochrome P450 3A4 (CYP3A4) [ 43 ], which participates in testosterone metabolism [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…CPF also downregulates genes essential for gonadotropin production and steroidogenesis, which may explain its effect on FSH and LSH levels [ 45 ]. Since FSH is essential for spermatogenesis, low sperm counts after CPF treatment might be due to reduced FSH levels [ 42 ]. Concurrent administration of CPF + OLE produces a dramatic elevation in serum testosterone, LH, and FSH.…”

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract Attenuates Chlorpyrifos-Induced Neuro- and Reproductive Toxicity in Male Albino Rats

Hassan

Salah

Fahmy

et al. 2022

Life

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Chlorpyrifos (CPF) is a common organophosphorus insecticide. It is associated with negative consequences such as neurotoxicity and reproductive injury. This study aimed to observe the ability of olive leaf extract to attenuate chlorpyrifos toxicity, which induced neuro- and reproductive toxicity in male albino rats. Olive leaf extract (OLE) exhibits potent antioxidant and antiapoptotic properties. Twenty-two mature male rats were divided into four groups: control (saline), CPF (9 mg/kg), OLE (150 mg/kg), and CPF + OLE. Treatment was administered orally for 80 days. The CPF significantly reduced serum sex hormones, sperm counts and motility, high oxidants (MDA), and depleted antioxidants (GSH, SOD, TAC) in the brain and testes homogenate; additionally, it decreased serum AChE and brain neurotransmitters, increased Bax, decreased Bcl-2, and boosted caspase-3 immune expression in neural and testicular cells. Immunological expression of Ki 67 in the cerebrum, cerebellum, choroid plexus, and hippocampus was reduced, and α-SMA in testicular tissue also decreased. Histopathological findings were consistent with the above impacts. OLE co-administration significantly normalized all these abnormalities. OLE showed significant protection against neural and reproductive damage caused by CPF.

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“…Among androgens, testosterone (T) has a vital niche in the modulation of normal spermatogenesis and maintaining sexual integrity along with frequent copulation through ejaculatory reflex (Corona & Maggi, ). It is well established that testosterone‐mediating signaling is necessary for genomic and transcriptional pathways, exposing the translocation of the androgen‐bound androgen receptor (AR) to the nucleoplasm, its dimerization and attachment with specific androgen response elements on promoter region, and subsequent modulation of target gene expressions, leading to androgen‐dependent cell proliferation (Smith et al ., ). In our study, regarding the length of microsatellite CAG and GGC repeats, infertile patients do not differ significantly from the control group.…”

Section: Discussionmentioning

confidence: 97%

Serotonin transporter (5‐HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation

Khan¹,

Bhatti

Abbas³

et al. 2018

Andrology

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Premature ejaculation is one of the most common sexual disorders in men due to uncontrolled modulation of spinal reflexes controlled by cortico-limbic centers in the brain. In this study, we investigate the combinatorial effects of trinucleotide repeats of androgen receptor and allelic variants of the 5-HTTLPR gene on sex steroids, hypophyseal hormones, sexual performance, and premature ejaculation assessment parameters among evidence-based lifelong premature ejaculation subjects. A total of 271 outpatients (age 26.6 ± 1.9) consulting for evidence-based lifelong premature ejaculatory dysfunction were selected in this study. The control group consists of 155 men with normal IELT (>4 min). The study revealed that the subjects who have the highest (≥26) CAG stretches depicted a significantly higher serum oxytocin levels (102.1 pg/ml; n = 126, p < 0.001) compared with the control group (71.2 pg/ml; n = 75, p = <0.001) and patients which have medium (22-25) and short (≤21) CAG stretches (76.63 ng/ml; n = 64, p < 0.001 vs. 77.4 ng/ml; n = 81, p < 0.001). Almost 33 (26.1%) lifelong premature ejaculatory patients had AR variant of longer (≥26) CAG repeats was homozygous for S alleles (SS), 45 (35.7%) was homozygous for L allele (LL), and 48 (38%) had the L/S or S/L genotype of 5-HTTLPR gene. Homozygous (SS) alleles have a significant positive correlation (r = 0.44, p < 0.0001) with the high score of BDI-II (39.1, n = 126, p < 0.001). However, LL alleles have shown a significant positive correlation with PEDT (r = 0.46, p < 0.001) and negative correlation with self-estimated IELT and intercourse satisfaction (r = -0.35, p < 0.001). The innovative study design elaborates that androgen receptor trinucleotide repeats and 5-HTTLPR genotypes have combinatorial impact on hormonal milieu and sexual function regarding evidence-based lifelong premature ejaculatory dysfunction patients.

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Hormonal regulation of spermatogenesis through Sertoli cells by androgens and estrogens

Cited by 8 publications

References 145 publications

The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats

The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats

Olive Leaf Extract Attenuates Chlorpyrifos-Induced Neuro- and Reproductive Toxicity in Male Albino Rats

Serotonin transporter (5‐HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation

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