1997
DOI: 10.1155/1998/87527
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Hormonal Regulation of Uterine Macrophages

Abstract: Macrophages are major cellular inhabitants of cycling and pregnant mammalian uteri. Their densities and patterns of tissue distribution in this organ fluctuate in concert with levels of circulating female sex steroid hormones, estrogens and progesterone, and their production of various effector molecules also may be hormonally regulated. Hormonal control may be achieved by direct binding to receptors or by indirect pathways where hormones modulate production of various autocrine and paracrine cytokines and gro… Show more

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Cited by 69 publications
(41 citation statements)
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“…Estrous stage-associated shifts in macrophage location have previously been reported for mouse (Pollard et al 1998, Shimada-Hiratsuka et al 2000 and rat (Kachkache et al 1991), and the migration of neutrophils into the luminal epithelium at metestrus has been well documented (Corbeil et al 1985). Although E 2 and P 4 are often regarded as having pro-and antiinflammatory effects respectively on mouse uterus (Martin et al 1973a, 1973b, De & Wood 1990, Hunt et al 1998, Tibbetts et al 1998, the effects of E 2 and P 4 have never been tested in normal cycling mice. Our finding that neutrophil and macrophage migrations are not correlated with hormone levels suggests that in a physiological setting, these cells are influenced more by cyclical structural changes in the endometrium than by serum hormone levels themselves.…”
Section: Discussionmentioning
confidence: 98%
“…Estrous stage-associated shifts in macrophage location have previously been reported for mouse (Pollard et al 1998, Shimada-Hiratsuka et al 2000 and rat (Kachkache et al 1991), and the migration of neutrophils into the luminal epithelium at metestrus has been well documented (Corbeil et al 1985). Although E 2 and P 4 are often regarded as having pro-and antiinflammatory effects respectively on mouse uterus (Martin et al 1973a, 1973b, De & Wood 1990, Hunt et al 1998, Tibbetts et al 1998, the effects of E 2 and P 4 have never been tested in normal cycling mice. Our finding that neutrophil and macrophage migrations are not correlated with hormone levels suggests that in a physiological setting, these cells are influenced more by cyclical structural changes in the endometrium than by serum hormone levels themselves.…”
Section: Discussionmentioning
confidence: 98%
“…With marked paucity of lymphocytes, intraovarian cavity macrophages, and maybe neutrophils as well, may impart protection against pathogenic invasion in the ovarian lumen of N. ransonneti . Mammalian macrophages may also contribute to the sustainment of pregnancy by regulating immune responses (Hunt and Robertson, 1996;Hunt et al ., 1998). Macrophages in pregnant human uterus are major sites of production of prostaglandin E 2 (Norwits et al ., 1991), which suppresses lymphocyte activation and proliferation in placenta Lala et al ., 1988;Parhar et al ., 1989;Kvirkvelia et al ., 2002).…”
Section: Discussionmentioning
confidence: 99%
“…In the endometrium, macrophages represent an important mechanism of defense, including the degradation of cellular debris in endometrial shedding and repair and protection against infections. However, the mechanisms involved in recruiting, maintaining, and activating uterine macrophages are not fully defined (41)(42)(43). In situ hybridization has shown that the expression of UCP2 in the uterus is restricted to the endometrium, especially in epithelial cells and uterine glands.…”
Section: Ucp2(ϩ/ϩ)/t(ϫ/ϫ) and Ucp2(ϫ/ϫ)/t(ϩ/ϩ) Micementioning
confidence: 99%