Hormonal therapy in female pattern hair loss

Brough, Kevin; Torgerson, Rochelle R.

doi:10.1016/j.ijwd.2017.01.001

Cited by 37 publications

(44 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recall, StAR has been demonstrated to play an important role in the production of steroid hormones by the transfer of cholesterol from the outer mitochondrial membrane to the inner membrane in steroidogenic tissue sites . Estrogen biosynthesis is important because it prolongs the anagen phase of the hair follicle during pregnancy and in case studies of patients with a genetic predisposition to pattern hair loss or during menopause …”

Section: Steroidogenesis (Aromatase and 5α‐reductase) Expression And mentioning

confidence: 99%

“…43 Estrogen biosynthesis is important because it prolongs the anagen phase of the hair follicle during pregnancy and in case studies of patients with a genetic predisposition to pattern hair loss or during menopause. 15,[44][45][46][47] In regard to pregnancy, this represents a state of hypercortisol, where this major stress hormone increases up to fourfold that has been described as a high-stress physiological state (60 μg/ mL-morning, and 20 μg/mL-afternoon). 48 Hair cortisol has been reported as a novel biomarker of hypothalamic-pituitary-adrenocortical activity, since it is incorporated into the hair shaft and studies have suggested that cortisol inhibits hair growth.…”

Section: S Teroidog Ene S Is ( Aromata S E and 5 α-Reduc Ta S E) E mentioning

confidence: 99%

See 1 more Smart Citation

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective

Lephart

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Summary Several journal reports, reviews, and commentaries over the last 20‐25 years have pointed out the controversy attached to 17β‐estradiol's inhibitory or stimulatory influence on hair follicle growth/cycling citing rodent (murine) and human results. While 17β‐estradiol is the most potent sex steroid hormone in the body and has almost equal affinity for estrogen receptor (ER) alpha (α) and beta (β), there appears to be specific ER‐mediated effects on scalp hair follicles/growth, etc. Additionally, the newly discovered G protein‐coupled estrogen receptor (GPR30 or GPER) and the orphan receptor, estrogen‐related receptor (ERR) gamma (γ), in skin and other tissue sites have potential impacts of how estrogens via these receptors may alter scalp hair characteristics, but this remains to be elucidated. Conversely, the negative impact of the 5α‐reductase enzyme and its steroid product, 5α‐dihydrotestosterone, on scalp hair growth is clear. Less clear is how 17β‐estradiol is stimulatory in some scalp hair studies, but inhibitory in others. This brief summary examines the potential influences of steroidogenesis via aromatase (estrogen biosynthesis) and 5α‐reductase expression, their enzyme activities, and steroid products along with the concepts of how steroid acute regulatory protein (StAR) and estrone sulfate may be involved in the complex hormonal, cellular/molecular signaling cascade of the hair follicle in growth and cycling.

show abstract

Section: Steroidogenesis (Aromatase and 5α‐reductase) Expression And mentioning

confidence: 99%

Section: S Teroidog Ene S Is ( Aromata S E and 5 α-Reduc Ta S E) E mentioning

confidence: 99%

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective

Lephart

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…In one survey, 40% of women experienced marital problems and 64% had career difficulties that they ascribed to their hair loss. 5 Alopecia can also be the first symptom of underlying systemic illness within the primary care setting. 1,6 FPHL is a non-scarring alopecia characterised by progressive transformation of thick, pigmented terminal hair into short, thin, non-pigmented villous hair.…”

mentioning

confidence: 99%

“…This undesired process is known as hair follicle miniaturisation. 1,3,5,6 The trigger for miniaturisation remains unclear but is postulated to be a combination of genetic predisposition, androgen influence and other not yet elucidated factors. Androgens exert their effect on hair via circulating levels of testosterone, which is produced in females by the ovaries and adrenal glands.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Female pattern hair loss

Chan¹,

Cook²

2018

Aust J Gen Pract

View full text Add to dashboard Cite

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Nayana,

Shankaranarayana Rao,

Srikumar

2024

J of Neuroscience Research

View full text Add to dashboard Cite

Finasteride is used in female‐pattern hair loss, hirsutism, and polycystic ovarian syndrome. It inhibits 5α‐reductase, which is an important enzyme in the biosynthesis of neurosteroids. The effects of finasteride treatment on mental health in female patients as well as the effects of repeated/chronic finasteride administration in female rodents are still unknown. Accordingly, in our study, we administered finasteride (10, 30, or 100 mg/Kg, s.c.) for 6 days in female rats and evaluated behavior, plasma steroid levels, and synaptic plasticity. Depression‐like behavior was evaluated using forced swim test (FST) and splash test. Anxiety‐like behavior was evaluated using novelty‐suppressed feeding task (NSFT), elevated plus maze (EPM), open field test (OFT), and light–dark test (LDT). Plasma steroid levels were assessed using ELISA and synaptic plasticity by field potential recordings. We observed that finasteride decreased total immobility duration in FST, indicating antidepressant‐like effect and decreased the latency to first bite in NSFT, showing anxiolytic‐like effect. We also found a significant increase in plasma estradiol and a significant decrease in plasma corticosterone level. Furthermore, field potential recordings showed that finasteride increased hippocampal long‐term potentiation. These results indicate that repeated finasteride administration in female rats may have antidepressant‐ and anxiolytic‐like effect, which might be mediated by enhanced estradiol levels or decreased corticosterone levels. Further studies are required to validate the molecular mechanisms underlying the effects of finasteride in female rats. Understanding the mechanisms will help us in developing novel neurosteroid‐based therapeutics in the treatment of neuropsychiatric disorders in women.

show abstract

Hormonal therapy in female pattern hair loss

Cited by 37 publications

References 55 publications

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective

Female pattern hair loss

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Contact Info

Product

Resources

About