Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women

Rajkumar, Chakravarthi; Kingwell, Bronwyn A.; Cameron, James D.; Waddell, Tamara K.; Mehra, Rishi; Christophidis, N.; Komesaroff, Paul A.; McGrath, Barry P; Jennings, Garry; Sudhir, Krishnankutty; Dart, Anthony M.

doi:10.1016/s0735-1097(97)00191-5

Cited by 265 publications

(176 citation statements)

References 43 publications

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“…Karpanou et al 18 noticed that in hypertensive women reaching natural menopause, compared with age-matched hypertensive controls, aortic root function abruptly deteriorated as evidenced by significant declines in the distensibility and the cross-sectional compliance and by a rise in the aortic stiffness index. 18 Other studies are in keeping with our findings, but did not correct for the level of blood pressure [19][20][21] or reported that withdrawal of hormonal replacement therapy for 4 weeks resulted in a decrease of systemic arterial compliance and an increase in pulse wave velocity in the femoralisdorsalis pedis region, but not in the aorto-femoral territory. 21 Recent studies using ambulatory monitoring [22][23][24][25][26] or automated blood pressure self-measurement 27 are…”

Section: Discussionsupporting

confidence: 73%

Menopause and the characteristics of the large arteries in a population study

et al. 2001

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In previous cross-sectional and longitudinal population studies, we found that the slope of systolic pressure on age was steeper in postmenopausal than in premenopausal women. We hypothesised that this observation could be due to a specific effect of menopause on the elasticity of the large arteries. We investigated 315 randomly selected women, aged 30 to 70 years. Based on 5.2 years of follow-up, 166 women were premenopausal and 149 menopausal (44 reaching menopause and 105 postmenopausal). These women were matched on age and body mass index with 315 men. We used a walltracking ultrasound system to measure the diameter, compliance and distensibility of the brachial and the common carotid and femoral arteries as well as carotidfemoral pulse wave velocity. Pulse pressure was determined from 24-h blood pressure recordings. Both in menopausal women (r = 0.37; P Ͻ 0.001) and in matching male controls (r = 0.16; P = 0.04), pulse pressure widened with increasing age. The slope of the 24-h pulse pressure on age was steeper in menopausal

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Section: Discussionsupporting

confidence: 73%

Menopause and the characteristics of the large arteries in a population study

et al. 2001

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“…19 Therefore measures of central aortic compliance may be most suitable for detecting cardiovascular change, for example the effect of hormone replacement therapy. 20 Nevertheless the intention may be to determine not the presence or propensity to disease, but the relationship to age and possibly to examine biological age, defined as the difference between chronological and estimated age.…”

Section: Discussionmentioning

confidence: 99%

The effect of age on vascular compliance in man: which are the appropriate measures?

et al. 1999

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“…Waveforms were acquired and analyzed by purpose-written computer programs. 29 Mean values of up to 10 waveform sets were used. The carotid blood pressure waveform was calibrated assuming equivalence between mean and diastolic pressures at the brachial and carotid sites.…”

Section: Arterial Stiffness Measurementsmentioning

confidence: 99%

The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients

et al. 2011

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Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r ¼ À0.207, P ¼ 0.014).After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85,), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83,), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.

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Hormonal Therapy Increases Arterial Compliance in Postmenopausal Women

Cited by 265 publications

References 43 publications

Menopause and the characteristics of the large arteries in a population study

Menopause and the characteristics of the large arteries in a population study

The effect of age on vascular compliance in man: which are the appropriate measures?

The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients

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