Hormonal treatment and psychological function during the menopausal transition: An evaluation of the effects of conjugated estrogens/cyclic medroxyprogesterone acetate

Khoo, S. K.; Coglan, M.; Battistutta, Diana; Tippett, V; Raphael, Bram P.

doi:10.3109/13697139809080682

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…58 Three RCTs that assessed the secondary effects of HRT on anxiety symptoms in peri-and postmenopausal women reported little or no effects. [59][60][61] A large trial that randomized 419 postmenopausal women to 4 different HRT regimens found only modest effects of hormone treatments on anxiety scores after a long (up to 9 years) follow-up period. 62 However, these negative findings may be explained in part by a floor effect, because most study participants revealed relatively low anxiety scores at study entry.…”

Section: Managing Anxiety During Midlifementioning

confidence: 99%

Challenges and Opportunities to Manage Depression During the Menopausal Transition and Beyond

Soares

Frey

2010

Psychiatric Clinics of North America

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Section: Managing Anxiety During Midlifementioning

confidence: 99%

Challenges and Opportunities to Manage Depression During the Menopausal Transition and Beyond

Soares

Frey

2010

Psychiatric Clinics of North America

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“…3 Potential benefits for this woman include improvement of menopausal symptoms, such as hot flashes, 6 sleep disturbances, [28][29][30] urogenital atrophy, 31,32 and possibly mood disorders. 28,[33][34][35][36][37][38] Evidence for improvement of hot flashes is based on a large number of randomized controlled trials of symptomatic women in their late 40s and early 50s. 6,39 Improvement in sleep disturbances [28][29][30] and urogenital atrophy 31,32 is supported by a fewer number of randomized controlled trials reporting a variety of measures.…”

Section: Patient 1: Initiating Therapy In a Perimenopausal Woman Withmentioning

confidence: 99%

Postmenopausal Estrogen for Treatment of Hot Flashes

Nelson¹

2004

JAMA

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trogen has changed since the release of the first results from the Women's Health Initiative (WHI) in 2002. 1 Professional organizations, 2 the US Food and Drug Administration (FDA), 3 and the US Preventive Services Task Force 4 have issued new recommendations against use of estrogen and progestin or progesterone for prevention of chronic conditions. Recent announcements of termination of the estrogen-only group of the WHI due to increased incidence of strokes among estrogen users increases concerns about safety. 5 Treatment of menopausal symptoms remains an indication for estrogen use, and the FDA advises physicians to use the smallest effective dose for the shortest duration possible. 3 Most menopausal women experience symptoms at menopause that include vasomotor symptoms, such as hot flashes, sleep disturbances, mood changes, urogenital atrophy, and other adverse events that can diminish quality of life. Although many women have mild, transient symptoms, many other women find their symptoms disruptive. For these women, estrogen may serve a useful role in short-term symptom management. This article applies the current state of evidence for postmenopausal estrogen use to management decisions in 2 clinical scenarios.

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“…Examples of such scales are the General Health Questionnaire 27,28 , the Hamilton Rating Scales of Clinical Anxiety and Depression 29,30 , the Beck Depression Index 27,28,31,32 , the Zung Anxiety Scale 33 and the Kellner-Sheffield Scale 33 . Examples of such scales are the General Health Questionnaire 27,28 , the Hamilton Rating Scales of Clinical Anxiety and Depression 29,30 , the Beck Depression Index 27,28,31,32 , the Zung Anxiety Scale 33 and the Kellner-Sheffield Scale 33 .…”

Section: Standardized Clinical Instruments As Dependent Variablesmentioning

confidence: 99%

Has psychosocial research on the menopause any clinical relevance?

Greene

2003

Climacteric

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The relevance of the findings of longitudinal studies, and other types of psychosocial studies, of general population samples of climacteric women to day-to-day clinical practice is examined. It is shown that the findings of such studies can act as a useful guide to the assessment and treatment of menopausal women in a clinical setting. However, it is argued that the relevance of these studies to clinical practice could be even greater if certain clinically derived considerations were taken into account in the methodology and design of such studies, and therefore provide a more clinically relevant evidence base for the overall management of women at the time of the menopause.

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Hormonal treatment and psychological function during the menopausal transition: An evaluation of the effects of conjugated estrogens/cyclic medroxyprogesterone acetate

Abstract: The use of hormones, given as a continuous estrogen and cyclic progestogen formulation after a formal calibration/run-in period, may have a beneficial effect on psychosocial distress experienced by women towards the end of their reproductive function.

Cited by 15 publications

References 22 publications

Challenges and Opportunities to Manage Depression During the Menopausal Transition and Beyond

Challenges and Opportunities to Manage Depression During the Menopausal Transition and Beyond

Postmenopausal Estrogen for Treatment of Hot Flashes

Has psychosocial research on the menopause any clinical relevance?

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