Hormonal Treatment of Cancer

Nathanson, Ira T.; Kelley, Rita M.

doi:10.1056/nejm195201242460405

Cited by 49 publications

(5 citation statements)

References 124 publications

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“…Hormone challenge is an old concept in the management of breast cancer [30]. In the 1920s, an ''estrogen challenge'' was used to determine the potential benefit of oophorectomy; in women with bone metastases, elevation of urinary calcium excretion after an estrogen challenge predicted response to subsequent oophorectomy.…”

Section: Discussionmentioning

confidence: 99%

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

Dehdashti¹,

Mortimer

Trinkaus³

et al. 2008

Breast Cancer Res Treat

193

173

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Section: Discussionmentioning

confidence: 99%

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

Dehdashti¹,

Mortimer

Trinkaus³

et al. 2008

Breast Cancer Res Treat

193

173

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“…The findings reported for the action of anterior pituitary preparations on the mammary fibroadenoma are of particular interest in view of the currently increasing evidence of the part played by pituitary hormones in carcinogenesis (Moon, Simpson, Li and Evans, 1950;Moon, Simpson and Evans, 1952;Noble and Walters, 1954).…”

Section: Discussionmentioning

confidence: 96%

“…It is well known that excessive estrogen will inhibit the growth of some malignant neoplasms in rats and mice (Eisen, 1941;Nathanson and Salter, 1939) and in humans such action is well exemplified by the use of estrogen therapy for breast cancer. The variability of response in humans (Nathanson and Kelley, 1952) From a therapeutic point of view the desirability of such a response in the fibroadenoma is questionable, since the incidence of malignant transformations was increased in the groups treated during tumour growth, this event being coincident with tumour growth inhibition. In the preceding paper (Millar and Noble, 1954) it was shown that the change to fibrosarcoma was restricted to slow growing fibroadenomata and it was proposed that the fibrosarcomatous transformation was instigated in an effort to overcome the action of some intrinsic inhibitory agent.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exogenous Hormones on Growth Characteristics and Morphology of Transplanted Mammary Fibroadenoma of the Rat

Millar¹,

Noble²

1954

Br J Cancer

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THE description of a line of transplanted mammary fibroadenomata in rats was presented in a preceding paper from this laboratory (Millar and Noble, 1954).Observations by us and others have shown that this type of tumour is more easily propagated, grows more rapidly and usually shows greater epithelial development in the female host than in the male. In addition, castration in males and females increases and decreases respectively the growth energy of transplanted mammary fibroadenomata in rats. In order to elucidate further the nature of the hormonal control of these benign tumours, experiments have been carried out to determine the effect of administered pituitary, adrenal and sex hormones on their growth and morphology.The effect of estrogens on the growth of mammary fibroadenomata in rats has been studied by several workers with somewhat conflicting results. Heiman and Krehbiel (1936) found no consistent tumour response to administered estrogens. However, estrogen (theelin) plus growth hormone (Antuitrin S) or gonadotrophic hormone (Antuitrin G) increased the number of tumour takes in intact rats, although none of the individual preparations were active. Antuitrin S alone was effective in increasing the takes in castrated males and females, while estrogen and growth hormone were again effective only when injected simultaneously. In these experiments tumours of the 13th to 22nd generations were used.Estrogen administration to rats bearing auto-and homo-transplants of spontaneous tumours produced marked tumour epithelial proliferation and increased growth rate (Heiman, 1940b). Mohs (1940)

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“…7 the mouse-uterine-weight method. Their observations were interpreted as indicating a dichotomy of response between luteinizing hormone and follicle-stimulating hormone in man.…”

Section: Cancer July 1954mentioning

confidence: 99%

Hormonal therapy in cancer of the breast.VII. Effect of conjugated estrogens (equine) on clinical course and hormonal excretion

Segaloff

Gordon

Carabasi

et al. 1954

Cancer

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Hormonal Treatment of Cancer

Cited by 49 publications

References 124 publications

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

Effects of Exogenous Hormones on Growth Characteristics and Morphology of Transplanted Mammary Fibroadenoma of the Rat

Hormonal therapy in cancer of the breast.VII. Effect of conjugated estrogens (equine) on clinical course and hormonal excretion

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