Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study

Abstract

Forty postmenopausal women, referred for hormone replacement therapy and all of whom reported a significant concern about a decline in their sexual interest, were randomly allocated to one of two hormone implant treatment groups: either oestradiol (50 mg) alone, or oestradiol (50 mg) and testosterone (100 mg). Comparison between the two groups as a whole revealed no significant differences on any measure,

Literature review of instruments to assess health-related quality of life during and after menopause

“…The first documented practical application of the original (1976) Greene Climacteric Scale dates back to 1983 [15]. A trial was performed on 40 women with varying degrees of menopausal symptoms recruited from a hormone replacement clinic.…”

Testosterone therapy in women: a review

“…29,32,35,37 Additionally, several of the trials demonstrated that the addition of androgens improved sense of well being and other 'psychological factors'. 30,38,42,43,46 In the one trial of premenopausal women, testosterone therapy was also found to be effective in improving sexual desire, arousal and satisfaction. 33 …”

Androgen insufficiency in women

“…Subsequently, as shown in Table 2, a multitude of trials have examined the effects of testosterone on sexual function in pre-and post-menopausal women [23][24][25][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Together, these trials indicate that testosterone treatment which results in high (premenopausal) physiologic or slightly supraphysiologic testosterone levels increases arousability, desire, fantasy, frequency of sexual activity, frequency of orgasm, sexual satisfaction, and pleasure, and decreases personal distress.…”