Hormone Interactions in Endometrial Cancer

Kamal, Areege Mustafa; Tempest, Nicola; Maclean, Alison; Adishesh, M; Bhullar, J.; Makrydima, Sofia; Hapangama, Dharani

doi:10.1007/978-3-319-64513-1_6

Cited by 2 publications

(2 citation statements)

References 202 publications

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“…Obesity also causes a high risk for several cancers like breast cancer, endometrial cancers, etc. [8,[51][52][53].…”

Section: Causesmentioning

confidence: 99%

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Withdrawal Notice: Pathophysiology of Poly Cystic Ovarian Syndrome

Manu¹,

Soni²,

Victòria³

et al. 2021

CWHR

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Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy that affects 8% to 20% of the reproductive age females and adolescent girls every year worldwide and approximately 5 million cases reported in the USA annually. It is more prevalent in urban areas as compared to the rural areas because of the difference in the lifestyles of rural and urban ladies. Rarely PCOS is passed on by heredity in some cases. Objectives: We sought to understand the pathophysiology and role of various genes in PCOS. Methods: We have done rigorous literature reviews on different aspect of PCOS and compiled here in this review. Results: It mostly occurs due to a lack of awareness. Its symptoms become mild to severe like initially hirsutism, acne which further leads to irregular periods and infertility. The pathogenesis of PCOS is not known because it is a complex multi-genetic disorder i.e. it involves one or more than one abnormal alteration in its genome. Its main clinical manifestations are insulin resistance and increased level of androgen. So, the treatment regimen of this disorder is focused on reducing levels of androgen, which helps to diminish the long-term risk of diabetes and CVD (Cardiovascular disease). Metformin is used to sensitize the insulin because the risk of glucose intolerance also gets elevated with insulin resistance, type-2 diabetes, and lipid abnormalities. Conclusions: Likely, the outcome of different, deeply interrelated genetic abnormalities that influence each other and perpetuate the syndrome may be represented by PCOS.

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“…Obesity also causes a high risk for several cancers like breast cancer, endometrial cancers, etc. [8,[51][52][53].…”

Section: Causesmentioning

confidence: 99%

“…The critical genetic variations in PCOS across different ethnicities and their associated effects such as hyperandrogenism in women [56], insulin resistance [3,17,22,[56][57][58], miscarriage, recurrent pregnancy loss, endometrial receptivity [59]. Women suffering from PCOS are more prone to different types of cancers [8,53,60,61].…”

Section: Causesmentioning

confidence: 99%

Withdrawal Notice: Pathophysiology of Poly Cystic Ovarian Syndrome

Manu¹,

Soni²,

Victòria³

et al. 2021

CWHR

View full text Add to dashboard Cite

show abstract

Pathophysiology of Polycystic Ovarian Syndrome

Manu¹,

Soni²,

Victòria³

et al. 2022

Polycystic Ovary Syndrome - Functional Investigation and Clinical Application

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Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy that affects 8–20% of the reproductive age females and adolescent girls every year worldwide and approximately 5 million cases reported in the USA annually. It is more prevalent in urban areas as compared to the rural areas because of the difference in the lifestyles of rural and urban ladies. Rarely PCOS is passed on by heredity in some cases. It mostly occurs due to a lack of awareness. Its symptoms become mild to severe like initially hirsutism, acne which further leads to irregular periods and infertility. The pathogenesis of PCOS is not known because it is a complex multi-genetic disorder. Ovary and adrenal steroid genesis, the action of steroid hormone, action and regulation of gonadotropin, action, and secretion of insulin, obesity, and regulation of energy in PCOS involve genes. Its main clinical manifestations are insulin resistance and increased level of androgen. Metformin is used to sensitize the insulin because the risk of glucose intolerance also gets elevated with insulin resistance, type-2 diabetes, and lipid abnormalities. Likely, the outcome of different, deeply interrelated genetic abnormalities that influence each other and perpetuate the syndrome may be represented by PCOS.

show abstract

Hormone Interactions in Endometrial Cancer

Cited by 2 publications

References 202 publications

Withdrawal Notice: Pathophysiology of Poly Cystic Ovarian Syndrome

Withdrawal Notice: Pathophysiology of Poly Cystic Ovarian Syndrome

Pathophysiology of Polycystic Ovarian Syndrome

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