2006
DOI: 10.1210/jc.2005-1836
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Hormone Predictors of Bone Mineral Density Changes during the Menopausal Transition

Abstract: Spine and hip BMD losses during the menopause transition were most strongly related to the interaction between initial FSH levels and longitudinal FSH changes and not to E2 or androgen levels or changes.

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Cited by 225 publications
(205 citation statements)
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“…A potential direct stimulatory action of FSH on bone mass in vivo, although awaiting definitive proof, is clinically meaningful in view of the close correlation between bone loss and changes in serum FSH, rather than sex steroids measured across the menopausal transition (21). In another study, plasma levels of inhibin correlate with bone mass more strongly than with FSH (22).…”
Section: Discussionmentioning
confidence: 96%
“…A potential direct stimulatory action of FSH on bone mass in vivo, although awaiting definitive proof, is clinically meaningful in view of the close correlation between bone loss and changes in serum FSH, rather than sex steroids measured across the menopausal transition (21). In another study, plasma levels of inhibin correlate with bone mass more strongly than with FSH (22).…”
Section: Discussionmentioning
confidence: 96%
“…osteoporosis | sex steroids | skeletal anabolic | gonadotropin W omen lose over 3% of bone mass during late perimenopause at which time estrogen levels remain relatively unperturbed (1,2). This bone loss begins 3 y before the last menstrual period (3), and arises from a profound elevation in bone resorption, which is not compensated by parallel increases in bone formation (4).…”
mentioning
confidence: 99%
“…Strong correlations between rising serum FSH levels and bone loss have been documented, particularly in the Study of Women's Health Across Nations (SWAN) (2,6). Furthermore, amenorrheic women with high FSH levels >35 IU/L display greater decrements in bone density than those with a mean FSH of ∼8 IU/L (7).…”
mentioning
confidence: 99%
“…Epidemiologic data from the Study of Women's Health Across the Nation (SWAN study) had implicated the menopause-associated rise in serum FSH as more important than declining estrogen levels in determining bone mineral density (BMD) (Sowers et al 2006;Sowers et al 2003) or prevalence and frequency of vasomotor symptoms (Randolph, Jr. et al 2005) in perimenopausal women.…”
Section: New Information On the Direct Roles Of Gonadotrophic Hormonementioning
confidence: 99%