Hormone profiling, <scp>WHO</scp> 2010 grading, and <scp>AJCC</scp>/<scp>UICC</scp> staging in pancreatic neuroendocrine tumor behavior

Morin, Emilie; Mete, Özgür; Serra, Stefano; Araujo, Paula Bruna; Temple, Sara; Cleary, Sean P.; Gallinger, Steven; Greig, Paul D.; McGilvray, Ian; Wei, Alice C.; Sylvia, L.; Ezzat, Shereen

doi:10.1002/cam4.96

Cited by 30 publications

(26 citation statements)

References 20 publications

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“…The observed mean age of PNEN patients, 59.4 years, was slightly higher than in other studies (48-53 years), possibly due to having an adult group, in contrast with the presence of adolescent patients in other studies that showed an age range of 14-78 years [34,41,42]. Although in this study, women accounted for 75.0% of patients, PNEN incidence is considered equal in both sexes.…”

Section: Clinical Datacontrasting

confidence: 85%

“…PNENs are associated with significantly better outcomes than is pancreatic ductal adenocarcinoma (PDAC). The median survival of surgically treated non-functional PNENs was 60.4 months and the mean survival of PNEN patients reached 225.3 months [34,35]. In contrast, the median survival of surgically treated PDAC was 22.8 months [36].…”

Section: Discussionmentioning

confidence: 94%

“…Although in this study, women accounted for 75.0% of patients, PNEN incidence is considered equal in both sexes. The observed difference is probably attributable to the relatively small size of the study group [34,41].…”

Section: Clinical Datamentioning

confidence: 86%

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Original paper Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms

Simtniece¹,

Vanags²,

Štrumfa³

et al. 2015

pjp

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The study represents a comprehensive retrospective morphological and immunohistochemical profiling of pancreatic neuroendocrine neoplasms (PNENs) in order to reveal the associations between morphological and molecular parameters. The local tumour spread (T), presence of metastases in regional lymph nodes (N) and distant organs (M), tumour grade (G) and resection line status (R) by pathology findings (pTNMGR), mitotic activity, perineural, vascular and lymphatic invasion were assessed in 16 surgically resected PNENs. By immunohistochemistry, expression of Ki-67, p53, p27, p21, cyclin D1, Bcl-2, E-cadherin, CD44, vimentin, cyclooxygenase 2 (COX-2), microvascular density, and cytokeratin (CK) spectrum, along with neuroendocrine, intestinal and squamous markers were detected. Descriptive statistics, Chi-square test, Spearman's rank correlation, Mann-Whitney and Kruskal-Wallis methods were applied; p < 0.05 was considered significant. Ki-67, CK19, p63, vimentin and COX-2 were significantly up-regulated in PNENs in comparison to benign pancreatic islets. A complex network of morphological and molecular associations was identified. Ki-67 correlated with PNEN size (p = 0.022), the World Health Organization 2004 and 2010 classification grades (p = 0.021 and p = 0.002), stage (p = 0.028) and mitotic count (p = 0.007) but among molecular markers -with CK19 (p = 0.033) and vimentin (p = 0.045). CK19 was significantly up-regulated in PNENs, having higher pT (p = 0.018), pR (p = 0.025), vascular (p = 0.020), perineural (p = 0.026) and lymphatic invasion (p = 0.043). In conclusion, proliferation activity (by Ki-67), E-cadherin, vimentin and CK19 are important molecular characteristics of PNENs due to significant associations with morphological tumour characteristics, pTNMGR and invasive growth.

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Section: Clinical Datacontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 94%

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Original paper Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms

Simtniece¹,

Vanags²,

Štrumfa³

et al. 2015

pjp

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“…Insulinoma constitutes approximately 25% of all pancreatic neuroendocrine tumors (PNETs), which represent only 1-2% of all pancreatic neoplasms [3,4]. Clinical diagnosis of insulinoma often takes a long time because of the numerous effects of hypoglycemia and the difficulty of localization, especially when the tumors are small.…”

Section: Discussionmentioning

confidence: 99%

“…While NAFLD is associated with metabolic risk factors such as obesity, diabetes, and dyslipidemia, its etiology remains largely unknown and the development or co-existence of NAFLD in patients with insulinoma has not been investigated [1][2][3][4]. Here we report a case of insulinoma with NAFLD, in which surgical resection of the tumor drastically improved NAFLD-related parameters and hypoglycemia.…”

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confidence: 88%

A case of insulinoma with non-alcoholic fatty liver disease: Roles of hyperphagia and hyperinsulinemia in pathogenesis of the disease

et al. 2015

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Abstract. Nonalcoholic fatty liver disease (NAFLD) is a serious health-related condition all over the world; the number of patients is increasing in Asian countries including Japan. Better understanding of its pathophysiology is required to develop effective therapeutics, as patients may go on to develop non-alcoholic steatohepatitis and hepatocellular carcinomas. While NAFLD is believed to be associated with metabolic risk factors such as obesity, diabetes, and dyslipidemia, its etiology remains largely unknown and the development or co-existence of NAFLD in patients with insulinoma has not been investigated. A 33-year-old male with an insulinoma, who had been hypoglycemic during the previous four years, developed abnormally elevated levels of liver enzymes and histological fatty liver characteristic of NAFLD by the time of admission to our hospital for resection of an insulinoma. His medical records for the previous eight years revealed that his bodyweight had increased gradually from 60 kg to 71 kg for seven years and then acutely increased to 79 kg in the latest one-year period. This sudden increase was thought to be due to the patient's self-described overeating of fruits to forestall hypoglycemia. Fresh fruits are rich in fructose, and the patient's triglycerides, alanine and aspartate transaminases showed an acute increase in the previous one-year period. After resection of the insulinoma, the levels of these parameters all were mostly restored, which suggests that hyperinsulinemia and subsequent hyperphagia played a role in the development of NAFLD in this case. This is the first report of patient with NAFLD and an insulinoma.Key words: Insulinoma, Non-alcoholic fatty liver disease, Fibroscan, Fructose steatohepatitis and hepatocellular carcinomas [1][2]. While NAFLD is associated with metabolic risk factors such as obesity, diabetes, and dyslipidemia, its etiology remains largely unknown and the development or co-existence of NAFLD in patients with insulinoma has not been investigated [1][2][3][4]. Here we report a case of insulinoma with NAFLD, in which surgical resection of the tumor drastically improved NAFLD-related parameters and hypoglycemia. Case PresentationA 33-year-old male suspected of insulinoma was referred to Kansai Electric Power Hospital for surgical resection of the tumor. His fasting plasma glucose lev-

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PET/MRI imaging in neuroendocrine neoplasm

et al. 2022

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Hormone profiling, WHO 2010 grading, and AJCC/UICC staging in pancreatic neuroendocrine tumor behavior

Cited by 30 publications

References 20 publications

Original paper Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms

Original paper Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms

A case of insulinoma with non-alcoholic fatty liver disease: Roles of hyperphagia and hyperinsulinemia in pathogenesis of the disease

PET/MRI imaging in neuroendocrine neoplasm

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