Hormone receptors analysis in Chinese patients with dermatofibrosarcoma protuberans

Abstract

This finding suggests that progesterone may have potential effects in growth of DFSPs. Further studies are needed to fully address this question.

Dermatofibrosarcoma protuberance in a black African cohort – a clinicopathologic study

“…Our study supports these findings with the majority being younger than 40 years, it also supports the finding by Kreicher et al [3] in the United States which reported modal age of occurrence at 20 to 39 years.Most studies report a predilection for truncal location as has been shown in this study [3,4,6,8], while a study in Italy and another in Thailand reported the most common tumour site as the extremities [5,10]. Occurrence at other sites occur including perineal and acral sites are varied in incidence according to different studies [6,[8][9][10]. This diverse tumour locations may suggest multiplicity in risk factors for these tumours as has been shown by molecular profiling [2].Tumour recurrence after complete surgical excision with negative margins is common with a study reporting as high as 22% [6].…”

“…In our study, however, most cases presented with recurrence at the time of first consultation in our hospital, hence, negative tumour margins could not be ascertained. This present study has shown a recurrence following 20 years after primary tumour resection and this may be one of the longest duration so far reported in literature with a few reporting 10 years [8], while cases showing recurrence few weeks after resection has also been documented [8]. Patients could therefore be expected to develop recurrence beyond the recommended follow up interval [6].We believe that this study is one of the few to report male predominance [5] compared to most studies reporting more cases in females [3,4,8,10], with a study in Nigeria showing equal gender incidence [7].…”

“…Another study that reported male predominance considered only acral site tumours, hence, the study may not be representative of all cases seen in that population. Indeed, a subset of DFSP tumours have shown progesterone receptor positivity [8], suggesting a role of gender in its tumourigenesis. While male gender has been associated with poorer survival [3,4], role of gender have not been demonstrated in these tumours.…”

“…It is, therefore, regarded as a low-grade sarcoma with excellent 10 year survival of 99% [2,6].Studies on dermatofibrosarcoma protuberance from Nigeria are few [7], hence the need to undertake this study. More so, cases of missed diagnosis are frequent with patients often presenting as a recurrence before accurate diagnosis is made [8,10]. Thus, this study reviewed the clinicopathological features of cases of dermatofibrosarcoma protuberance seen in our hospital and compared these to studies in other populations.…”

“…It is known that DFSP can occur at any location in the skin. Different studies show differences with regards to the commonest site of occurrence [ 3 – 5 , 8 ]. The occurrence in unusual locations such as the acral sites [ 9 ] and the perineum/vulva [ 6 ] have also been documented.…”