Hormone-regulated PKA activity in porcine oviductal epithelial cells

Teijeiro, Juan Manuel; Marini, Patricia Estela

doi:10.1007/s00441-020-03180-2

Cited by 4 publications

(1 citation statement)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, GLO2 phosphorylation was not investigated in either of the cases. Very recently, a protein kinase A-dependent hormone-regulated phosphorylation of both GLO1 and GLO2 was identified in porcine ampulla and primary cell cultures, but the enzyme activities were not revealed [79].…”

Section: Regulation Of Glyoxalases With Glyoxalase II In the Focusmentioning

confidence: 99%

Metabolic Shades of S-D-Lactoylglutathione

Kalapos¹,

Antognelli

Bari

2022

Antioxidants

View full text Add to dashboard Cite

S-D-lactoylglutathione (SDL) is an intermediate of the glutathione-dependent metabolism of methylglyoxal (MGO) by glyoxalases. MGO is an electrophilic compound that is inevitably produced in conjunction with glucose breakdown and is essentially metabolized via the glyoxalase route. In the last decades, MGO metabolism and its cytotoxic effects have been under active investigation, while almost nothing is known about SDL. This article seeks to fill the gap by presenting an overview of the chemistry, biochemistry, physiological role and clinical importance of SDL. The effects of intracellular SDL are investigated in three main directions: as a substrate for post-translational protein modifications, as a reservoir for mitochondrial reduced glutathione and as an energy currency. In essence, all three approaches point to one direction, namely, a metabolism-related regulatory role, enhancing the cellular defense against insults. It is also suggested that an increased plasma concentration of SDL or its metabolites may possibly serve as marker molecules in hemolytic states, particularly when the cause of hemolysis is a disturbance of the pay-off phase of the glycolytic chain. Finally, SDL could also represent a useful marker in such metabolic disorders as diabetes mellitus or ketotic states, in which its formation is expected to be enhanced. Despite the lack of clear-cut evidence underlying the clinical and experimental findings, the investigation of SDL metabolism is a promising field of research.

show abstract

Section: Regulation Of Glyoxalases With Glyoxalase II In the Focusmentioning

confidence: 99%