Hormone Release during Mating in the Male Rat: Time Course, Relation to Sexual Behavior, and Interaction with Handling Procedures*

Kamel, Freya; Frankel, Arthur I.

doi:10.1210/endo-103-6-2172

Cited by 85 publications

(30 citation statements)

References 3 publications

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“…This finding is similar to that reported for several mammalian species (Szachman et al, 1974;Agmo, 1976;Kamel and Frankel, 1978;Bronson and Desjardins, 1982;Rabb et al, 1989;Borg et al, 1991;Retana-Márquez et al, 1998). However, the physiological significance of these increases has not been elucidated.…”

Section: Discussionsupporting

confidence: 91%

“…However, it has been shown that there is an increase of both corticosterone and testosterone after masculine sexual behavior in several mammal species (Szachman et al, 1974;Agmo, 1976;Kamel and Frankel, 1978;Rabb et al, 1989;Borg et al, 1991;Retana-Márquez et al, 1998), suggesting that both axes are activated simultaneously by sexual behavior.…”

Section: Introductionmentioning

confidence: 99%

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Plasma levels of corticosterone and testosterone after sexual activity in male rats treated neonatally with clomipramine

Bonilla-Jaime

Retana‐Márquez

Vazquez-Palacios

et al. 2003

Behavioural Pharmacology

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Neonatal treatment with clomipramine (CMI) in rats, induces alterations of pleasure-seeking behaviors during adulthood. Alterations of hormonal responses to stressful situations have also been reported. In this study, the levels of corticosterone and testosterone in response to sexual activity were assessed in rats treated neonatally with CMI. Male pups received subcutaneous injections of CMI (15 mg/kg, 0.1 ml), twice a day (09.00 hours and 18.00 hours) from 8 to 21 days of age. A control group received saline in the same number of injections. Four months after CMI treatment, subjects (Ss) were submitted to the forced swim test to verify the effect of CMI. Thereafter, they were tested to assess their spontaneous sexual activity. Plasma levels of corticosterone and testosterone were assessed under different conditions. Results of sexual behavior and the forced swim test corroborate the depressive-like effect of CMI. The sole presence of an estrogenized stimulus female caused an increase in plasma levels of testosterone in both control and CMI-treated Ss. The same was true for corticosterone; however, this increase was significantly lower in the CMI-treated group. There is a discrepancy between the normal hypothalamus-pituitary-gonadal (HPG) response and the decreased sexual behavior. The data suggest that CMI induces permanent changes in the reactivity of the hypothalamic-pituitary-adrenal axis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Plasma levels of corticosterone and testosterone after sexual activity in male rats treated neonatally with clomipramine

Bonilla-Jaime

Retana‐Márquez

Vazquez-Palacios

et al. 2003

Behavioural Pharmacology

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“…It is well established that receptive female rats can evoke in males a surge in luteinizing hormone, followed by a substantial increase in plasma androgen levels [e.g., [13][14][15]36]. Neutral cues that are associated with the presence of females can also come to evoke luteinizing hormone surges as well as increased levels of androgen [6], The functional significance of such increases in plasma androgen has been uncertain, however, because basal (presurge) levels of an drogen have appeared to be adequate to maintain normal levels of copulatory behavior and its component reflexes [3,4] as well as normal spermatogenesis [37].…”

Section: Discussionmentioning

confidence: 99%

Rapid Effect of Testosterone on Striated Muscle Activity in Rats

Sachs¹,

Leipheimer²

1988

Neuroendocrinology

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We addressed the question of how rapidly gonadal steroids might affect behavior by studying how fast testosterone (T) could augment the actions of the striated penile muscles and their associated penile reflexes. Eight male rats, functionally castrated 4 months before this study, bore chronically implanted electrodes in the bulbospongiosus (bulbocavernosus) muscle. The males were observed for the display of penile reflexes immediately after the injection of T (250 µg i.m.) and T propionate (250 µg s.c), as well as after injections of only the oil vehicle. Overt penile responses were rare. However, in several tests subcutaneous twitching was observable near the midline posterior to the penis. These twitches were accompanied by electromyographic bursts and were attributed to contractions of the bulbospongiosus muscle. T reliably (p < 0.025) accelerated the onset of electromyographic activity: 6 of the 8 males had electromyographic bursts before the 30-min limit, and 3 males responded within 6 min. This is the first demonstration of such a rapid action of androgens on behavior or its basis in striated muscle activity. The rapid muscular response to T was ascribed to steroid-sensitive neuronal membrane receptors. Such responsiveness could increase the intensity of penile reflexes within minutes after surges of luteinizing hormone and T have been induced by cues associated with estrous females and thereby could contribute to the fertility of mating.

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“…Increased numbers of spermatozoa in the epididymis may be another of the acute responses. Exposure to a female pro¬ vokes pulses of testosterone (Taylor, Haller, Rupich & Weiss, 1984) and LH (Kamel & Frankel, 1978) and it may release oxytocin (Sharma & Hays, 1976) which could result in elevated numbers of spermatozoa moving quickly through the epididymis (Swierstra, Pickett & Gebauer, 1975;Agmo, Andersson & Johansson, 1978).…”

Section: Discussionmentioning

confidence: 99%

Copulation induces an acute increase in epididymal sperm numbers in rats

Taylor¹,

Weiß²,

Frechmann³

et al. 1985

Reproduction

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The temporal changes in epididymal sperm numbers during the month after sexual contact were examined in 80 adult albino rats. The comparably sexually experienced males in 6 experimental groups were allowed 3 ejaculations with ovariectomized females in which oestrus was induced by hormone injections. Epididymides were removed from the experimental males 1 h, 1 day, 2 days, 3 days, 7 days or 30 days later. Control males were sexually inexperienced or sexually experienced and living with females. Epididymal sperm counts revealed a pattern that resembled an inverted V-shaped function with a peak at 48 h after copulation. We suggest that sexual activity provokes an acute attenuation of sperm disposal within the epididymis with the result that more spermatozoa are available for ejaculation during sexually active times.

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Hormone Release during Mating in the Male Rat: Time Course, Relation to Sexual Behavior, and Interaction with Handling Procedures*

Cited by 85 publications

References 3 publications

Plasma levels of corticosterone and testosterone after sexual activity in male rats treated neonatally with clomipramine

Plasma levels of corticosterone and testosterone after sexual activity in male rats treated neonatally with clomipramine

Rapid Effect of Testosterone on Striated Muscle Activity in Rats

Copulation induces an acute increase in epididymal sperm numbers in rats

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