2008
DOI: 10.1002/14651858.cd003122.pub2
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Hormone replacement therapy for cognitive function in postmenopausal women

Abstract: Analysis 1.2. Comparison 1 The e ect of ERT/HRT versus placebo on global cognition scores, Outcome 2 3MSE score a er CEE + MPA (variable follow up

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Cited by 124 publications
(92 citation statements)
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“…These short-term trials consistently suggested a neuroprotective effect of estrogen when initiated after oophorectomy [12] .…”
Section: Evidence Of Neuroprotective Effects Of Estrogen In Women Befmentioning
confidence: 77%
“…These short-term trials consistently suggested a neuroprotective effect of estrogen when initiated after oophorectomy [12] .…”
Section: Evidence Of Neuroprotective Effects Of Estrogen In Women Befmentioning
confidence: 77%
“…Some observational studies support a positive association between use of estrogen-containing hormone therapy and cognitive function in healthy women, but the results of randomized controlled trials have failed to show clear evidence of benefit (Henderson and Sherwin, 2007;Lethaby et al, 2008), and there is even some suggestion of mild detriment (Espeland et al, 2004;Maki et al, 2007). While this topic remains one of ongoing debate, the basic question of whether endogenous serum levels of these hormones influence cognitive performance remains uncertain.…”
Section: Introductionmentioning
confidence: 99%
“…[4][5][6] However, a Cochrane review found that there is little evidence that estrogen or combined estrogen and progestin therapy protects against a decline in overall cognitive functioning of healthy older postmenopausal women. 7 A substudy of the Women's Health Initiative (WHI) looked at the effects of postmenopausal HT on a variety of outcomes, including cognition. In subjects receiving conjugated equine estrogens (CEE) plus progestin, an almost doubled risk of all-cause dementia was shown.…”
mentioning
confidence: 99%