Hormone replacement therapy may improve hepatic function in women with Turner's syndrome

Elsheikh, Mohgah; Hodgson, H. J. F.; Wass, John; Conway, Gerard S.

doi:10.1046/j.1365-2265.2001.01321.x

Cited by 94 publications

(63 citation statements)

References 19 publications

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“…On the other hand, that such lesions are associated with functional deficits cannot be excluded from our data. We saw that a short 2 month course without HRT lead to elevation of liver enzymes, readily suppressible by standard HRT, as also documented previously (3)(4)(5). Recently, the same response to HRT, albeit less pronounced, has also been found among postmenopausal women (27).…”

Section: Discussionsupporting

confidence: 55%

“…We and others have shown a normalizing effect of hormone replacement therapy (HRT), containing 17b-estradiol and a gestagen, on liver enzymes (3)(4)(5), which may point towards a protective effect on hepatocyte integrity. Marked architectural changes, including nodular regenerative hyperplasia, multiple focal nodular hyperplasia and cirrhosis are observed in some patients and are associated with a risk of liver-related complications.…”

Section: Introductionmentioning

confidence: 99%

“…Stature is short, and morbidity is increased due to risk of osteoporosis and fractures, type 2 diabetes, ischemic heart disease, hypertension, and stroke, but also the risk of cirrhosis is increased (1). Clinical studies have shown a frequent occurrence of elevated liver enzymes, primarily alanine aminotransferase (ALAT), g-glutamyl-transferase (gGT), and alkaline phosphatase (AP), while bilirubin is normal (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

et al. 2007

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Background: Studies have documented elevated levels of liver enzymes in many females with Turner syndrome (TS). Histology has shown a range of changes. Treatment with female hormone replacement therapy (HRT) reduces liver enzymes. Aim: To study quantitative liver functions in TS in detail with and without HRT. Design: Randomized crossover study with active treatment (HRT in TS and P-pill in controls) or no treatment. Subjects: Women with TS (nZ8, age 29.7G5.6 (meanGS.D.) years), verified by karyotype, and agematched controls (C; nZ8, age 27.3G4.9 years). Methods: We determined liver enzymes in blood, used the galactose elimination capacity to assess hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, antipyrine clearance to estimate microsomal activity, and the functional hepatic nitrogen clearance (FHNC) to assess mitochondrial-cytosolic metabolic capacity for conversion of amino-nitrogen. Results: Liver enzymes were elevated in untreated TS and reduced by HRT. The hepatic capacities for conversion of galactose, indocyanine green, and antipyrine were normal and did not change by HRT.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

et al. 2007

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“…Although there have been very few reports of frank liver disease in women with Turner's syndrome, elevated liver enzymes have been reported, 81 and the use of different forms of estrogen replacement may ameliorate or exacerbate this problem. 82 There are currently insufficient data to make specific recommendations. There has not been an increased occurrence of breast cancer among patients with Turner's syndrome.…”

Section: Cardiovascular Concernsmentioning

confidence: 99%

Turner's Syndrome

2004

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“…The prevalence of these abnormalities ranges from 20 to 80%, depending on the patient’s age [1,3,4,5,6] inasmuch as these abnormalities become more frequent with advancing age.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Enzyme Abnormalities in Turner Syndrome: A Case Report

Pervanidou¹,

Xekouki²,

Dacou-Voutetakis³

2007

Horm Res Paediatr

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Background: Liver dysfunction has been described in subjects with Turner syndrome. The mechanism involved is not known. Methods: Using appropriate methodology, we evaluated the hepatic enzymes serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and γ-glutamyl transpeptidase (γ-GT) in a girl with 45 XO/46 Xr mosaic karyotype. She was monitored from age 9 to 20 years while she underwent various therapeutic regimens. Results: Serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and particularly γ-GT concentrations ranged from normal to elevated values during human growth hormone therapy, estrogen replacement therapy (conjugated estrogens were replaced after 1 year with transdermal estrogens and medroxyprogesterone), and periods without therapy. The type of the therapeutic regimen did not seem to influence the hepatic enzyme values. A correlation was found between γ-GT values and body mass index (BMI). Conclusions: In our patient the waxing and waning of the liver enzymes was not influenced by the therapeutic regimen, but γ-GT seemed to correlate with BMI.

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Hormone replacement therapy may improve hepatic function in women with Turner's syndrome

Abstract: Women with Turner's syndrome often have elevated liver enzymes. Oestrogen/progestagen therapy using oestradiol valerate improves liver function in this group of patients. The mechanisms behind this are unclear.

Cited by 94 publications

References 19 publications

Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

Turner's Syndrome

Hepatic Enzyme Abnormalities in Turner Syndrome: A Case Report

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