Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

Gökkuşu, Cahide; Özbek, Zeynep; Tata, Gulten

doi:10.1007/s00404-011-2051-2

Cited by 8 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Escalante Gómez and Quesada Mor found lower 8-OH-2dG levels in women receiving combined HRT compared to women who did not receive therapy [126], while TBARS were lower in women on ERT compared to non-users. Another recent study reported a decrease of TBARS, but unvaried levels of serum homocysteine and carbonyls in postmenopausal women under HRT compared to women receiving oral placebo [127]. At variance with this report, Unfer et al [128] found no difference in serum TBARS between healthy postmenopausal women without/with HRT.…”

Section: Hrt (And/or Ert) and Oxscontrasting

confidence: 52%

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

Cervellati

Bergamini

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

Abstract:The postmenopausal phase of life is frequently associated in women with subjective symptoms (e.g. vasomotor) and real diseases (atherosclerosis with coronary ischemia, osteoporosis, Alzheimer-type neurodegeneration, urogenital dystrophy), which together determine the post-menopausal syndrome. Observations that oxidative damage by reactive oxygen/nitrogen species in experimental models can contribute to the pathogenesis of these disturbances stimulated research on the relationships between menopause, its endocrine deficiency, oxidative balance and the "wellness" in postmenopausal life. The connection among these events is probably due to the loss of protective actions exerted by estrogens during the fertile life. Most recent studies have revealed that estrogens exert an antioxidant action not by direct chemical neutralization of reactants as it was expected until recently but by modulating the expression of antioxidant enzymes that control levels of biological reducing agents. Also nutritional antioxidants apparently act by a similar mechanism. From this perspective it is conceivable that a cumulative control of body oxidant challenges and biological defenses could help in monitoring between "normal" and "pathological" menopause. However, as clinical studies failed to confirm this scenario in vivo, we have decided to review the existing literature to understand the causes of this discrepancy and whether this was due to methodologic reasons or to real failure of the basic hypothesis.

show abstract

Section: Hrt (And/or Ert) and Oxscontrasting

confidence: 52%

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

Cervellati

Bergamini

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…Females had lower Hcy levels compared with males, and Hcy was not a significant risk factor for females. This difference might be due to female hormones, which were demonstrated to have antioxidant effects that may antagonize the risk based on Hcy [32] . Further studies are needed to investigate the mechanism, but gender is an important factor that should be considered in future studies on the relationship between Hcy and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

et al. 2014

View full text Add to dashboard Cite

Homocysteine (Hcy) is regarded as a risk factor for hypertension, but research on the causal relationship between Hcy and hypertension is limited. In the present study, we prospectively tracked the blood pressure progression of a normotensive population with different Hcy levels over a 2-year period. The incidence of hypertension with increasing Hcy quartiles produced an approximately U-shaped curve, with significance in males. Compared with the third quartile, the risk of hypertension in the first and second quartiles was increased by 1.55 (95% confidence interval [CI] 1.154–2.081) fold and 1.501 (95% CI 1.119–2.013) fold, respectively, with the increase being more significant in males. In conclusion, Hcy is related to hypertension incidence with the results approximating an U-shaped curve. Low Hcy levels might also increase the risk of hypertension.

show abstract

“…The main studies about effect of HRT has been carried out with combination estrogen plus gestagen, and in them has been founded in example that carbonils groups determined by ELISA showed a reduction of serum levels after six months oral or transdermal treat when compared with control group, and there was not difference between oral and transdermal, which indicates that hormonal therapy reduces the of carbonyl protein, a marker of oxidative stress, suggesting potential protective effect [71]. Similar result were founded with the serum level of malondialdehyde, superoxide dismutase and sulfhydryl groups without changes on plasma total homocysteine (tHcy) (used as atherogenic indicator) [72]. Another study with equal number of months of follow-up showed that carbonyls, MDA and oxLDL were reduced, while erythrocyte glutathione (GSH) were increased, and nitrotyrosine (NT) levels were not changed [73,74] (Table 6).…”

Section: Six Monthsmentioning

confidence: 60%

Menopause Induces Oxidative Stress

Mendoza¹,

Jiménez-Zamarripa²

2013

Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants

View full text Add to dashboard Cite

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

Abstract: Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.

Cited by 8 publications

References 39 publications

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

Menopause Induces Oxidative Stress

Contact Info

Product

Resources

About