Hormone therapy for sexual function in perimenopausal and postmenopausal women

Lara, Lucia A; Cartagena-Ramos, Denisse; Figueiredo, Jaqueline BP; Rosa-e-Silva, Ana Carolina JS; Ferriani, Rui A; Martins, Wellington P; Fuentealba-Torres, Miguel

doi:10.1002/14651858.cd009672.pub3

Cited by 2 publications

(2 citation statements)

References 210 publications

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“…The selected confounders are shown to be associated both with sexual function and cardiovascular health. 3 , 7 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 Age was reported in years. Relationship happiness was evaluated with the question “How do you consider your current relationship?” and with answer options “very happy”, “fairly happy”, “neither happy nor unhappy”, “fairly unhappy”, and “very unhappy” and dichotomized as happy/unhappy.…”

Section: Methodsmentioning

confidence: 99%

“… 6 Use of systemic and local estrogen has been shown to be associated with better sexual function, especially concerning lubrication, pain, and satisfaction. 7 The role of testosterone is more debated. Although there is evidence to support testosterone as an effective treatment for FSD in postmenopausal women, less is known about the long‐term effects of testosterone treatment for FSD.…”

Section: Introductionmentioning

confidence: 99%

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Associations between arterial health and sexual function in women aged 60–64 years

Virkkunen,

Kero,

Koivisto

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionFemale sexual dysfunction is very common, but its determinants remain under‐investigated. Vasculogenic impairments are suggested to be related to female sexual dysfunction, but previous literature regarding the association is scarce. This study aims to study the association between arterial health and female sexual function in women in their 60s.Material and methodsThe sample for this cross‐sectional study comprised 117 women (aged 60–64 years) who participated in the Finnish Retirement and Aging study. Arterial health was measured according to the participants' pulse wave velocity, ankle–brachial index, blood pressure, and pulse pressure. Sexual function was measured using the Female Sexual Function Index, which resulted in a total score and six sub‐scores. Associations were examined using multivariable regression analyses, which were adjusted for age, relationship happiness, systemic menopausal hormone therapy and/or local estrogen, smoking, alcohol risk use, body mass index, and depressive symptoms.ResultsHigher diastolic blood pressure was associated with a higher total Female Sexual Function Index score (β = 0.24, 95% confidence interval [CI] 0.07–0.41) and with higher desire (β = 0.02, 95% CI 0.01–0.04), arousal (β = 0.04, 95% CI 0.01–0.08), lubrication (β = 0.04, 95% CI 0.002–0.08), satisfaction (β = 0.03, 95% CI 0.003–0.05), and pain (β = 0.06, 95% CI 0.02–0.10) sub‐scores. Also, higher ankle–brachial index was associated with higher satisfaction sub‐score (β = 2.10, 95% CI 0.44–3.73) and lower pulse pressure was associated with higher orgasm sub‐score (β = 0.03, 95% CI 0.0002–0.06). Other associations between ankle–brachial index and Female Sexual Function Index scores were statistically insignificant, but considering the magnitude the findings may imply clinical significance. Systolic blood pressure and pulse wave velocity were not associated with sexual function.ConclusionsThis study suggested a plausible association between higher diastolic blood pressure and female sexual function, but considering clinical significance our findings suggest an association between higher ankle–brachial index and good sexual function in women in their 60s.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between arterial health and sexual function in women aged 60–64 years

Virkkunen,

Kero,

Koivisto

et al. 2024

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

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Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

Guo,

Nan,

Liang

et al. 2024

Front. Nutr.

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BackgroundPolyunsaturated fatty acids (PUFAs) play a crucial role in maintaining homeostasis in the body. However, research on the relationship between PUFA intake and estradiol levels is limited. This study aims to investigate the association between dietary PUFA intake and estradiol levels in women in the United States.MethodData on PUFA intake and estradiol levels were drawn from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) for women aged 20 and older. UFA intake was assessed through 24-h dietary interviews, while serum estradiol levels were measured using isotope dilution liquid chromatography–tandem mass spectrometry (ID-LC–MS/MS). Weighted logistic regression models adjusted for covariates were used to analyze the relationship between PUFA intake and estradiol levels. The inflection point of the non-linear relationship between intake of PUFAs and estradiol levels was determined by threshold effects analysis, and a two-part regression model was developed at the inflection point.ResultWeighted multivariate linear regressions showed positive associations between eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) intake and estradiol levels. Even in the fully adjusted model, EPA intake remained positively associated with estradiol levels in the menopausal (β = 78.08, 95% CI: 33.58, 122.58; p = 0.0006), non-menopausal (β = 287.61, 95% CI: 177.29, 397.94; p < 0.0001), and total-participant groups (β = 208.38, 95% CI: 139.81, 276.95; p < 0.0001), and DPA intake remained positively associated with estradiol levels in the non-menopausal (β = 318.87, 95% CI: 28.93, 608.82; p = 0.0313) and total-participant groups (β = 208.03, 95% CI: 22.89, 393.18; p = 0.0277). In the two-part regression model, EPA intake greater than 0.09 (p < 0.0001) and DPA intake greater than 0.05 (p = 0.0033) were positively associated with estradiol levels in non-menopausal women.ConclusionThis study suggests that higher intake of EPA and DPA in non-menopausal women is associated with increased estradiol levels. These findings support the importance of dietary components in regulating female reproductive health and hormone levels.

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Hormone therapy for sexual function in perimenopausal and postmenopausal women

Cited by 2 publications

References 210 publications

Associations between arterial health and sexual function in women aged 60–64 years

Associations between arterial health and sexual function in women aged 60–64 years

Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

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