Hormones and cytokines in childhood obesity

Arslan, Nur; Erdur, Barış; Aydın, Adem

doi:10.1007/s13312-010-0142-y

Cited by 73 publications

(72 citation statements)

References 66 publications

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“…Adipokines secreted by visceral adipose tissue are associated with components of metabolic syndrome 4,7,10. Studies on obese children, adolescents and adults have evidenced a direct correlation between leptin and adiposity markers (BMI, WC and BFP) and with glucose, insulin and HOMA-IR values 8,9,34.…”

Section: Discussionmentioning

confidence: 99%

“…An excess of body fat not only results in metabolic changes in adipose tissue and the induction of insulin resistance but also leads to endothelial dysfunction via pro-inflammatory and pro-thrombotic effects due to the action of pro-inflammatory cytokines and adipokines 7. Leptin and adiponectin, which are the primary adipokines produced by adipose tissue, play important roles in the cardiometabolic outcomes associated with excess body weight 7,8.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

Clinics

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OBJECTIVE:This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents.METHODS:The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria.RESULTS:A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%.CONCLUSIONS:The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

Clinics

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show abstract

“…In addition, waist circumference (WC) was not associated with TNF-α concentrations. Arslan et al [11] concluded that TNF-α and IL-6 increased, while IL-10 decreased in obese children.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum IL-6, IL-8, MCP-1, CRP, and IFN-γ Levels in 10- to 11-Year-Old Boys with Increased BMI

Utsal

Tillmann

Zilmer³

et al. 2012

Horm Res Paediatr

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Background/Aims: Many inflammation parameters are associated with obesity, but few comparable data are found in youth. This study aims to characterize the differences in serum levels of 13 biochemical inflammatory markers between boys with increased BMI and boys with normal BMI, and examine the relationships between inflammation markers, skinfold thicknesses, and body composition. Participants/Methods: The participants were 38 boys (BMI above 85th percentile) and 38 boys (normal BMI) at the age of 10–11 years. Measurements included BMI, 9 skinfold thicknesses, waist and hip circumferences, and total body and trunk fat mass and percentage as indices of obesity, fasting insulin, glucose, and serum concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, IL-1β, monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor, and CRP. Results: Overweight boys (OWB) were taller and more frequently in puberty than normal-weight boys (NWB). Skinfold thicknesses and body composition parameters were higher in OWB. They had significantly higher serum IL-6, IL-8, IFN-γ, MCP-1, and CRP values compared to NWB. Conclusions: Six of 13 measured biochemical markers were significantly increased in OWB, indicating that many low-grade inflammatory processes are already involved in the development of obesity in childhood.

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“…with many biological activities [21]. Development and complications of obesity causes numerous adipokines, hormones and cytokines takenplace [22].…”

Section: Inhibitory Effect Of Mce On Lipid Content Of Liver In Hfd-fementioning

confidence: 99%

Myrciaria cauliflora extracts attenuating hyperlipidemia and obesity in vivo

Huang¹

2017

ijcrr

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Abstract:Obesity, the major reason causing the metabolic syndrome (MetS), leads to abnormal lipid metabolism, and also causes hyperlipidemia, morbidity and mortality in type 2 diabetes, cardiovascular and other diseases.These diseases often have increased insulin levels resulting from an insulin resistance lead to blood lipid abnormalities. Previously studies indicate that the polyphenols and anthocyanins ingredients have antioxidant, anti-arteriosclerosis, hypertension and diabetes suppression, hypolipidemic and tumor suppressor role. Therefore, this experiment will explore the preventive effect of extract from Myrciariacauliflora (MCE) for the high-fat diet-induced obesity and dyslipidemia. In this study, we investigated the chemopreventive potential of the water extract from Myrciariacauliflora (MCE) on the obesity male Wistar rat induced by lard oil for 10 weeks. The Serum biochemical parameters, body weight, were monitored every two weeks. After 10 weeks, the rats were sacrificed and the liver was assayed by HE stain and western blot. The results showed that dietary administration of MCE (0.5, 1, 1.5%) reduced the body weight of rat, serum biochemical parameters such as TG, TC, HDL-C, LDL-C, AST, ALT and lipid droplets in liver sections. Furthermore, MCE can also decrease the expression of lipid synthesis-related proteins by western blotting. These findings demonstrated that MCE prevented high-fat diet-induced high cholesterol and excess body fat, suggesting that MCE has a potentially protective effect in obesity-related and cardiovascular diseases.

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Hormones and cytokines in childhood obesity

Abstract: Development, pathogenesis and complications of childhood obesity consist of complex mechanisms including numerous cytokines and hormones. New treatment modalities depend on understanding these complex mechanisms.

Cited by 73 publications

References 66 publications

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Elevated Serum IL-6, IL-8, MCP-1, CRP, and IFN-γ Levels in 10- to 11-Year-Old Boys with Increased BMI

Myrciaria cauliflora extracts attenuating hyperlipidemia and obesity in vivo

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