Horsies and Bunnies: A Comparison of Antithymocyte Globulin in Allogeneic Stem Cell Transplant

Lu, Crystal; Neme, Klodiana; Mikulandric, Nancy; Grycki, Meredith; Pelland, Danielle; Farhan, Shatha; Janakiraman, Nalini; Peres, Edward; Vogel, Vishnuprabha; Szandzik, Ed

doi:10.1016/j.bbmt.2017.12.289

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“…Other study in adult population showed similar incidence of acute and chronic GVHD in horse and rabbit ATG group. 10,25,28 Veno-occlusive disease was seen in 35% of whole cohort and was higher in group-1 than group-2 and difference was significant (p value 0.039) which can be explained by relatedly older age and class III thalassemia were there in group-1.…”

Section: Discussionmentioning

confidence: 90%

Comparison Between Equine and Rabbit Anti-Thymocyte Globulin (Atg) Used in Conditioning for Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Bhat¹,

Chaudhary

Chakraborty

et al. 2020

Preprint

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Background: HSCT related complications and disease relapse are major obstacles in successful transplantation. Addition of ATG has shown to reduce rejection and Graft Vs Host Disease (GVHD) incidence significantly. Procedure: Here we report single center retrospective analysis for relative efficacy of rabbit and equine ATG during conditioning of pediatric patients who underwent HSCT. Results: Rabbit or Equine ATG were used as a part of conditioning regimen in 117 pediatric patients. Equine ATG group was labeled as group-1 and rabbit ATG as group-2. Both groups were analyzed for transplant related complications and outcome. In thalassemia, outcomes were comparable except Group-1 had more cases of proven bacterial infection (p=0.07) and veno-occlusive disease (p=0.03). In SAA, Group-1 had early neutrophil and platelet engraftment with less number of proven bacterial infections. Acute GVHD, chronic GVHD, median chimerism at day+30 and day+90 and overall survival (OS) was comparable in two groups, both in thalassemia and SAA patients. Analysis of 7 hematological malignancy cases and 10 immunodeficiency disorders also showed similar results. Conclusion: In conclusion, effectiveness of rabbit and horse ATG were similar in thalassemia, primary immunodeficiency patients and hematological malignancy while in SAA equine ATG use was associated with early neutrophil engraftment but OS in both groups were comparable.

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Section: Discussionmentioning

confidence: 90%