Hospital-acquired candidemia. The attributable mortality and excess length of stay

Wey, Sérgio Barsanti

doi:10.1001/archinte.148.12.2642

Cited by 430 publications

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“…Potential risk factors associated with candidaemia, such as the previous use of antimicrobial drugs, central lines, the use of corticosteroids, parenteral nutrition and surgery, were also identified in our study (Wey et al 1988, Colombo et al 2006, Sofair et al 2006, St-Germain et al 2008, Poikonen et al 2010.…”

Section: Discussionmentioning

confidence: 85%

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Wille¹,

Guimarães²,

Furtado

et al. 2013

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 85%

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Wille¹,

Guimarães²,

Furtado

et al. 2013

Mem. Inst. Oswaldo Cruz

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“…En otros estudios se ha informado que C. tropicalis es la más frecuente de las especies no albicans aislada de hemocultivos (14,26,27). En el estudio del grupo SENTRY (7), que incluyó cultivos de Suramérica, la frecuencia de las especies aisladas fue similar a la informada en este estudio en lo que concierne a C. albicans (40,5%), pero con variaciones en referencia a C. parapsilosis (38,1%), C. tropicalis 11,9%, C. glabrata y C. guilliermondii, 2,4% cada una, y otras especies, 4,7%.…”

Section: Discussionunclassified

“…Los servicios hospitalarios con mayor número de muestras positivas fueron los de dermatología con 493 (22,8%), medicina interna con 471 aislamientos (21,7%), y la unidades de cuidados intensivos con 312 aislamientos (14,4%), siendo los servicios de medicina interna y las unidades de cuidados intensivos los lugares donde se encuentran los pacientes con mayor riesgo de colonización, quienes pueden desarrollar candidiasis invasora, ya que tienen varios factores predisponentes (14,26,27).…”

Section: Discussionunclassified

Evaluación de la susceptibilidad de especies de Candida al fluconazol por el método de difusión de disco.

et al. 2003

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Las infecciones causadas por levaduras del género Candida han aumentado en forma dramática en las últimas décadas, especialmente a nivel hospitalario. Paralelamente con este aumento, se ha notado la aparición de resistencia a los antimicóticos, así como la selección de especies diferentes a Candida albicans, todo lo cual ha hecho necesaria la estandarización de pruebas de susceptibilidad in vitro. Entre las varias pruebas disponibles está la de difusión en agar con discos impregnados de antifúngicos, cuya lectura se hace electrónicamente (BIOMIC), lo que proporciona indicaciones objetivas de la concentración inhibitoria mínima (CIM). Se realizó el estudio para determinar la sensibilidad in vitro al fluconazol de 2.139 aislamientos de especies de Candida provenientes de pacientes atendidos en consulta externa o en salas de hospitalización de centros asistenciales en Colombia, Ecuador y Venezuela (región CELA). Candida albicans fue el microorganismo más frecuentemente aislado (62%), seguido a distancia por Candida parapsilosis (11%), Candida tropicalis (8,5 %), Candida glabrata (3,5%) y Candida krusei (2,2%). La CIM demostró que el 88,1% de estos aislamientos eran susceptibles al fluconazol, 5,1% eran susceptibles-dosisdependiente y 6,8% resistentes. El 92,1% de la especie C. albicans fue susceptible mientras que la resistencia al fluconazol fue más notoria en las restantes especies. El BIOMIC es un método rápido y sencillo para la vigilancia epidemiológica de resistencia en levaduras del género Candida recuperadas de pacientes atendidos en centros hospitalarios.Palabras clave: candidiasis, Candida, resistencia anfúngicos, fluconazol, prueba de disco. Resistance to fluconazole by Candida species detected using the disk diffusion method.Infections caused by yeasts belonging to the genus Candida have increased dramatically in the last decades, especially in hospital settings. Concomittantly, antimycotic resistance has emerged, as well as the appearance of non-Candida albicans isolates. To standardize in vitro antifungal susceptibility tests, the agar diffusion test was developed using disks impregnated with the antimycotic compound. Electronic recording of the inhibition zone (BIOMIC), furnishes objective values for the minimal inhibitory concentration (MIC). The fluconazole susceptibility patterns were determined for Candida species isolated from 2.139 patients seen in outpatient clinics or in health-care centers in Colombia, Ecuador and Venezuela. Candida albicans was the species most frequently isolated (62%), followed at a distance by Candida parapsilosis (11%), Candida tropicalis (8.5%), Candida glabata (3.5% ) and Candida krusei (2.2%). MIC determinations showed that 88.1% of these isolates were susceptible to fluconazole, 5.1% were susceptible-dose-dependant and 6.8% resistant. An important proportion (92.1%) of the C. albicans isolates proved susceptible while resistance predominated in the remaining species. These results indicate that the BIOMIC method is rapid and simple, constituting a suitable tool for ...

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“…[5][6][7] Neonatal candidemia occurs in 1.6 to 9% of VLBW infants 1,2 and 4 to 15% in extremely low birth weight infants (ELBW; birth weight <1000 g), with the 30-day mortality approaching 40%. 1,4,[8][9][10][11] The occurrence of candidemia has been reported as an independent risk factor associated with development of retinopathy of prematurity (ROP) [12][13][14][15][16][17] and ROP requiring laser surgery. 12 Yet others 18 have found such an association only in a univariate analysis but not in a multiple logistic regression model.…”

Section: Introductionmentioning

confidence: 99%

Systemic fungal infection is associated with the development of retinopathy of prematurity in very low birth weight infants: a meta-review

Bharwani

Dhanireddy

2007

J Perinatol

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Objective: To study the association between systemic fungal infection (SFI) and the development of retinopathy of prematurity (ROP) and severe ROP in very low birth weight (VLBW) infants by systematic review and meta-analysis.Study Design: A meta-review was performed using a fixed effects model. The exposure and outcomes studied were SFI and all ROP/severe ROP, respectively in VLBW infants. Results and effect sizes analyzed with Review Manager 4.2 software are expressed as relative risk (RR), odds ratio (OR), risk difference (RD) and number needed to harm (NNH) with 95% confidence intervals.Result: Data for severe ROP were available from eight studies and on all ROP from seven of those eight studies. Estimated gestational age ranged from 24.7±1.6 to 28.6±4 weeks and birth weight from 673 (median) (range 426 to 995) to 1108 ± 266 g (mean ± s.d.). A total of 261 of 303 babies with SFI had all ROP vs 1081 of 1648 babies without SFI (OR 3.4*, 2.34-4.95) and 118 of 330 babies with SFI had severe ROP vs 235 of 1951 babies without SFI (OR 4.06*,). The NNH was 5.56* (4.54-7.14) for all ROP and 4.54* (3.70 to 5.88) for severe ROP (*P<0.00001).Conclusion: SFIs are associated with the development of all degrees of ROP and severe ROP in VLBW infants.

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Hospital-acquired candidemia. The attributable mortality and excess length of stay

Cited by 430 publications

References 0 publications

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Evaluación de la susceptibilidad de especies de Candida al fluconazol por el método de difusión de disco.

Systemic fungal infection is associated with the development of retinopathy of prematurity in very low birth weight infants: a meta-review

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