Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality

Goldacre, Michael J; Roberts, Stephen E.

doi:10.1136/bmj.328.7454.1466

Cited by 197 publications

(140 citation statements)

References 19 publications

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“…The presumption that old age is a risk factor for mortality[5,7] is based upon case fatality rate (CFR), which does not take into account mortality in the background population.…”

Section: Introductionmentioning

confidence: 99%

First attack of acute pancreatitis in Sweden 1988 – 2003: incidence, aetiological classification, procedures and mortality – a register study

et al. 2009

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BackgroundPopulation-based studies suggest that the incidence of first attack of acute pancreatitis (FAAP) is increasing and that old age is associated with increased mortality. Beacuse nationwide data are limited and information on standardized mortality ratio (SMR) versus age is lacking, we wanted to describe incidence and mortality of first attack acute pancreatitis (FAAP) in Sweden.MethodsHospital discharge data concerning diagnoses and surgical procedures and death certificate data were linked for patients with FAAP in Sweden. Mortality was calculated as case fatality rate (CFR), i.e. deaths per 1000 patients and SMR using age-, gender- and calendar year-specific expected survival estimates, and is given as mean with 95% confidence intervals. Data are presented as median values with 25% and 75% percentiles, means and standard deviations, or proportions. Proportions have been compared using the chi square test, Poisson-regression test or Fisher exact test. Location of two groups of ratio scale variables were compared using independent samples t-test or Mann-Whitney U-test.ResultsFrom 1988 through 2003, 43415 patients (23801 men and 19614 women) were admitted for FAAP. Age adjusted incidence rose from 27.0 to 32.0 per 100000 individuals and year. Incidence increased with age for both men and women. At index stay 19.7% of men and 35.4% of women had biliary diagnoses, and 7.1% of men and 2.1% of women alcohol-related diagnoses. Of 10072 patients who underwent cholecystectomy, 7521 (74.7%) did so after index stay within the audit period. With increasing age CFR increased and SMR decreased. For the whole period studied SMR was 11.75 (11.34–12.17) within 90 days of index admission and 2.03 (1.93–2.13) from 91 to 365 days. Alcohol-related diagnoses and young age was associated with increased SMR. Length of stay and SMR decreased significantly during the audit period.ConclusionIncidence of FAAP increased slightly from 1988 to 2003. Incidence increased and SMR declined with increasing patient age. Although the prognosis for patients with FAAP has improved it remains an important health problem. Aetiological classification at index stay and timing of cholecystectomy should be improved.

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“…The presumption that old age is a risk factor for mortality[5,7] is based upon case fatality rate (CFR), which does not take into account mortality in the background population.…”

Section: Introductionmentioning

confidence: 99%

First attack of acute pancreatitis in Sweden 1988 – 2003: incidence, aetiological classification, procedures and mortality – a register study

et al. 2009

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“…In India, mean age of incidence for CP was found to be around 39.7 years [7]. An increasing trend in the incidence of acute pancreatitis and the total figure of hospitalisations for both acute and chronic pancreatitis has been shown in recent data, especially from predominantly western countries [8][9][10][11][12] . This trend has been observed by the practitioners as well; especially in the rural areas.…”

mentioning

confidence: 99%

Changing Trends in the Epidemiology of Pancreatitis in Rural Population: Study at a Tertiary Health Care Centre

Battin¹

2017

jmscr

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“…The proportion of alcohol-related cases remained reasonably constant over time for this population, although the proportion of cases with necrosis or other severe complications appeared to decrease slightly [36]. In one hospital-based study from the United Kingdom, 10% of 5312 people admitted for acute pancreatitis over a 35-year period had more than one recorded episode [37]. This was probably an underestimate of recurrence in that re-admissions within 12 months were not counted.…”

Section: Discussion Towards a Coherent Chronic Disease Management Strmentioning

confidence: 99%

Acute Pancreatitis is a Chronic Disease

Turner¹

2013

Pancreat Disorders Ther

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Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality

Cited by 197 publications

References 19 publications

First attack of acute pancreatitis in Sweden 1988 – 2003: incidence, aetiological classification, procedures and mortality – a register study

First attack of acute pancreatitis in Sweden 1988 – 2003: incidence, aetiological classification, procedures and mortality – a register study

Changing Trends in the Epidemiology of Pancreatitis in Rural Population: Study at a Tertiary Health Care Centre

Acute Pancreatitis is a Chronic Disease

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