Hospital admissions for peptic ulcer during 1958-72.

Brown, R. Christie; Langman, M. J. S.; Lambert, Peter

doi:10.1136/bmj.1.6000.35

Cited by 54 publications

(20 citation statements)

References 7 publications

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“…The peptic ulcer perforation rate in North-eastern Peninsular Malaysia is between 1 .S and 20 times lower than that reported from places as diverse as Helsinki (27). COpenhagen (28), Scotland (29), most of England (29), Rochester (USA) (30), Singapore (31). and Hong Kong (32).…”

Section: Discussionmentioning

confidence: 52%

Helicobacter pylori Infection in North-Eastern Peninsular Malaysia Evidence for an Unusually Low Prevalence

Uyub

Raj

Visvanathan

et al. 1994

Scandinavian Journal of Gastroenterology

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The prevalence of Helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia (NUD) patients, and in the general adult population. The H. pylori infection rate ascertained by microbiologic examination of multiple gastric antral biopsy specimens was 50% (17 of 34) in duodenal ulcer (DU), 5% (1 of 22) in gastric ulcer, and 9% (15 of 159) in NUD patients. A seroepidemiologic survey showed a prevalence of only 4.2% among 496 blood donors and 4.8% among 921 subjects who attended health screening clinics. H. pylori infection is relatively uncommon and does not appear to be the predominant factor in the pathogenesis of peptic ulcer disease in the area. The incidence of peptic ulcer perforations in the area in 1991-92 was 1.5 per 100,000 person-years, reflecting a relatively low frequency of peptic ulcers, which might be due to the low prevalence of H. pylori infection in the population.

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Section: Discussionmentioning

confidence: 52%

Helicobacter pylori Infection in North-Eastern Peninsular Malaysia Evidence for an Unusually Low Prevalence

Uyub

Raj

Visvanathan

et al. 1994

Scandinavian Journal of Gastroenterology

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“…The incidence of peptic ulceration is higher in Scotland and the north of England than further south 9 10. This difference has been the subject of speculation for some time9 10 but remains unexplained. There is now a recognised association between Helicobacter pylori infection, socioeconomic group,11 and childhood living conditions,12 and an increased prevalence of Helicobacter pylori infection has recently been found in the north of England and Scotland 13.…”

Section: Discussionmentioning

confidence: 92%

“…Peptic ulceration is the commonest disease underlying acute upper gastrointestinal haemorrhage in the United Kingdom 2 8. The incidence of peptic ulceration is higher in Scotland and the north of England than further south 9 10. This difference has been the subject of speculation for some time9 10 but remains unexplained.…”

Section: Discussionmentioning

confidence: 99%

Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study

Blatchford

Davidson

Murray

et al. 1997

BMJ

283

184

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The incidence of acute upper gastrointestinal haemorrhage was 67% greater than the highest previously reported incidence in the United Kingdom, which may be partially attributable to the greater social deprivation in the west of Scotland and may be related to the increased prevalence of Helicobacter pylori. Fatality after acute upper gastrointestinal haemorrhage was associated with age, comorbidity, hypotension, and raised blood urea concentrations on admission. Although deprivation was associated with increased incidence, it was not related to the risk of fatality.

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“…2 Between the 1950s and 1980s, hospital admissions and mortality from peptic ulcer declined in Britain for most age groups. [3][4][5] In contrast with this general trend, admissions for perforated peptic ulcer and mortality from duodenal ulcer increased among older women in the 1970s and 1980s. [5][6][7] Similar patterns have been noted in other Western countries 8-10 although a recent Danish study showed that hospitalisation and mortality from peptic ulcer complications have increased, especially among the elderly.…”

mentioning

confidence: 95%

Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects

Higham

2002

Gut

212

128

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Background: Although overall admission rates for peptic ulcer in England declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (NSAID). Since then, proton pump inhibitors, antibiotic treatment for Helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (SSRI) have been introduced Aims: To determine time trends for hospital admissions for peptic ulcer from 1989 to 1999 (England), mortality from 1958 to 1998 (England and Wales), and prescriptions for ulcer healing drugs, aspirin, NSAID, oral anticoagulants, and SSRI from 1990 to 1999 (England). Methods: Hospital episode statistics for admissions and mortality were obtained from the Office of National Statistics: community prescription data from Statistics Division 1E of the Department of Health. Results: Between 1989/90 and 1998/99, there was a marked rise in admissions for haemorrhage in older patients, particularly from duodenal ulcer. Perforations from gastric ulcer declined but perforations from duodenal ulcer increased among men at older ages. Since the mid 1980s mortality has declined in all age groups except for older women with duodenal ulcer. The number of prescriptions for histamine H 2 receptor antagonists remained constant but those for proton pump inhibitors increased by 5000%, aspirin 75mg by 460%, oral anticoagulants by 200%, and NSAID by 13% between 1990 and1999. Since the introduction of SSRI in 1991, prescriptions have increased 15-fold. Conclusions: Admission rates for gastric and duodenal ulcer haemorrhage and duodenal ulcer, but not gastric ulcer perforation, increased among older subjects, over a time when prescriptions for proton pump inhibitors, low dose aspirin, oral anticoagulants, and SSRI increased.

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Hospital admissions for peptic ulcer during 1958-72.

Cited by 54 publications

References 7 publications

Helicobacter pylori Infection in North-Eastern Peninsular Malaysia Evidence for an Unusually Low Prevalence

Helicobacter pylori Infection in North-Eastern Peninsular Malaysia Evidence for an Unusually Low Prevalence

Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study

Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects

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