Hospital based analytic study of peptic ulcer disease in patients with dyspeptic symptoms

Sharma, S; Maharjan, Dhiresh Kumar; Thapa, Pratima

doi:10.3126/kumj.v7i2.2706

Cited by 11 publications

(13 citation statements)

References 12 publications

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“…Another fascinating result is the 2.1-fold higher prevalence of strains with lowvirulence cagA ? /cagE -genotype in women compared with in men, which may imply a higher frequency of more virulent H. pylori strains in men and can explain, at least partially, the greater frequency and severity of gastroduodenal diseases such as duodenal ulcer in men than in women, as reported in some studies (Jafarzadeh et al 2007;Sharma et al 2009;Feinstein et al 2010).…”

Section: Discussionmentioning

confidence: 85%

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Boyanova

Yordanov

Gergova

et al. 2011

Antonie van Leeuwenhoek

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Associations of Helicobacter pylori cagE status with complex patient characteristics remain to be elucidated in Eastern Europe. The aim of this study was to assess the frequencies of cagE gene and cagA/cagE combinations in H. pylori strains from symptomatic Bulgarian patients and to improve cagA detection. cagA and cagE genotypes were evaluated in 219 patients with single-strain infections. In total, 84.9% of strains were cagA (+), while 68.5% were cagE (+). cagA (+), cagE (+), and cagA (+)/cagE (+) strains were more prevalent in peptic ulcer (93.8%, 84.4%, and 84.4%) compared with nonulcer patients (81.3%, 61.9%, and 61.3%, respectively). In elderly patients, cagE (+) and cagA (+)/cagE (+) strains were 1.9-fold more common than in the 12 children evaluated. Only 10% of the elderly subjects harbored low-virulence cagA (+)/cagE (-) strains compared with 16.8% of adults and 41.7% of children. Intriguingly, prevalence of the cagA (+)/cagE (-) genotype was 2.1-fold lower in men than in women, suggesting a higher frequency of more virulent strains in men. The presence of both cag genes and combinations was not linked to strain susceptibility to clarithromycin or metronidazole, place of residence, or prior therapy. Use of an extra primer pair increased cagA detection in 14.7% of 31 cagA (-) strains. In conclusion, use of a second primer pair for the cagA gene can be recommended in countries with common cagA (+) strains. Although both cag genes were linked to severe diseases in Bulgarian patients, the best discrimination of virulent strains was obtained by the cagA/cagE combination or by the cagE gene alone. cagE prevalence increased gradually with patient age, while the cagA (+)/cagE (-) genotype, implying a disrupted cag pathogenicity island, was associated with both younger age and female gender.

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Section: Discussionmentioning

confidence: 85%

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Boyanova

Yordanov

Gergova

et al. 2011

Antonie van Leeuwenhoek

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“…[10] Our study revealed that among the diagnosed medical conditions, the most prevalent was gastritis in 36% of the sample population; gastritis is a quite common health problem for the people of Nepal. [44] A study of 319 dyspeptic patients in Nepal Medical College (NMC) Teaching Hospital, Kathmandu, Bagmati Zone, Nepal revealed that the most common endoscopic finding in these patients was gastritis as found in 47.6% of the patients followed by normal findings in 17.8%. [45] In a Chinese study involving 25,627 random subjects aged 40 years or more, the overall prevalence of COPD was 8.2% (men: 12.4%; women: 5.1%).…”

Section: Discussionmentioning

confidence: 99%

Health and socioeconomic status of the elderly people living in Hilly areas of Pakhribas, Kosi Zone, Nepal

Gupta¹,

Lall²,

Das³

et al. 2016

Indian J Community Med

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Background:The rising geriatric population is facing significant health and social problems in the developing world that are impacting the quality of their lives.Objective:The study describes the general health status and the socioeconomic characteristics of the elderly people of Pakhribas village development committee (VDC) of Eastern Nepal.Materials and Methods:Descriptive cross-sectional study was carried out targeting the people aged 60 years and above in the sample area using a semi-structured questionnaire and convenient sampling to get the required sample size. A total of 189 elderly people who consented were interviewed in May 2010.Result:The major part of the elderly population was in the age group of 60-69 years. Seventy-two percent were illiterate and 75% were still earning with the majority involved in farming. Nine out of ten were living with their families and still made decisions for the household, Eighty-two percent did not feel lonely and 88.4% did not report any misbehavior by the house members. Regarding health, 69% had some diagnosed health issue with 36% suffering from gastritis and 20.4% from chronic lung disease. Using the ICD 10 criteria, depression was found among 18%. The most prevalent geriatric problem was a dental problem as found in 61% even though 87% claimed to brush their teeth regularly. More than half were suffering from visual difficulty and the proportions suffering from memory and hearing issues were also substantive. Smoking habit was found in 60%, and the relation between smoking and chronic respiratory diseases had a statistical association (P = <0.05). The geriatric cases who were misbehaved with felt depressed or neglected in the family (P = <0.0001).Conclusions:The results of the study show that employment, family support, and pension schemes have a positive impact on the social status of the elderly. Health screening clinics should be established in the community to detect health-related disorders. Elderly populations need health education to emphasize the importance of personal and dental hygiene and to abstain from smoking and alcohol.

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“…3 In the United States, approximately four million people have duodenal and gastric ulcer while 180,000 patients are hospitalized each year due to peptic ulcer disease. There is 10% likelihood of developing peptic ulcer in about 10% males and 4% females.…”

Section: Introductionmentioning

confidence: 99%

“…There is 10% likelihood of developing peptic ulcer in about 10% males and 4% females. 1,3 Peptic ulcer incidence in India is 2.9% and for gastric ulcer is 2.7%. important process of the stomach.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antiulcer activity of diltiazem in rats

Vare¹,

Bagle²,

Hire³

2017

Int J Basic Clin Pharmacol

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Background: The risk factors for patients with cardiovascular diseases and gastrointestinal diseases overlap. Majority of the patients have both problems coexistent. Thus, there is need of medicine that can be used for both the diseases.Methods: Rats weighing 150-250gm of either gender were procured for the study from central animal house. The animals were divided into 7 groups. Control group (Distilled water 2ml), diclofenac sodium (12mg/kg), diltiazem (10mg/kg), diltiazem (30mg/kg), diltiazem (60mg/kg), ranitidine (8mg/kg), ranitidine (16mg/kg). After six hours, scarification of animals was done by cervical dislocation. Size of ulcer, number of gastric ulcers, mean gastric irritancy index, ulcer index, and ulcer scoring were the parameters that were studied.Results: Diltiazem in dose of 10, 30 and 60 mg/kg showed reduction in all parameters in dose dependent manner. Diltiazem (60mg/kg) showed marked reduction in mean diameter of ulcerated surface area (0.46±0.36), number of ulcers (4.10±2.05), size of ulcers (1.07±0.48), total mucosal surface area (7.60±1.38), and total ulcerated surface area (0.263±0.3). Diltiazem (60mg/kg) showed significant reduction of the parameters as compared to other doses of Diltiazem. Also, diltiazem (60mg/kg) was comparable to Ranitidine in all the parameters. Diltiazem (60mg/kg) also showed reduction in average number of ulcers, ulcer index, mean gastric irritancy index and ulcer scoring as compared to diclofenac sodium (12mg/kg).Conclusions: Diltiazem has shown to have ulcer prevention property; this can be useful in patients having concomitant cardiovascular and gastrointestinal problems.

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Hospital based analytic study of peptic ulcer disease in patients with dyspeptic symptoms

Cited by 11 publications

References 12 publications

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Health and socioeconomic status of the elderly people living in Hilly areas of Pakhribas, Kosi Zone, Nepal

Evaluation of antiulcer activity of diltiazem in rats

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