Background: Chronic obstructive pulmonary disease (COPD) industriously influences the quality of life(QoL) with impairment of the physiological, psychosocial functions. Aim of the study: This study aimed to evaluate the effect of supportive nursing care on symptoms severity and QoL for patients with COPD. Subjects and Methods: Research design: a quasi-experimental design was used. Setting: The study was conducted at Chest Department and Chest Outpatient Clinic at Zagazig University Hospitals . Subjects: a purposive sample of forty five patients with COPD were included in this study. Tools of data collection: Patients' assessment questionnaire, Patients' observational checklists, COPD symptoms severity assessment scale, and the St George's quality of life respiratory questionnaire. Results: There were a lack in patients' knowledge, practice and QoL regarding COPD pre intervention, which increased in post and follow-up phases of intervention, with a statistically significant difference. Moreover, there was increase in COPD patients' symptoms severity before intervention, which decreased in post and follow-up phases, with a statistically significance difference. Conclusion: Patients with COPD who received supportive nursing care reported a reduction in symptoms severity and an improvement in QOL. Recommendations: Supportive nursing care should be implemented on a regular basis to improve COPD patients' knowledge, practice, and symptoms severity. Supportive nursing care training programs for nurses caring for COPD patients should be maintained.