Hospital Costs of Total Hip Arthroplasty for Developmental Dysplasia of the Hip

Ashraf, Ali; Larson, A. Noelle; Kremers, Hilal Maradit; Kremers, Walter K.; Lewallen, David G.

doi:10.1007/s11999-014-3587-9

Cited by 27 publications

(29 citation statements)

References 24 publications

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“…Longitudinal studies have revealed that degenerative changes induced by hip dysplasia develop more rapidly than in other predisposing conditions [77]. Total hip replacement (THR) is a surgical procedure that is most often performed in treating symptomatic advanced osteoarthritis, especially in younger age [78][79][80][81][82]. The diagnosis of DDH in first-order relative increases a chance for THR by the age of 65 [83].…”

Section: Natural History Of Ddh: Prevention Versus Operationmentioning

confidence: 99%

“…Recent studies show that average hospital cost for primary THR secondary to DDH is higher than in other cases. Also, the severity of DDH additionally increases those expenses [79,84]. If DDH is diagnosed early and the treatment was nonoperative, the rate of osteoarthritis at long-term follow-up is twice lower than after open reduction [81].…”

Section: Natural History Of Ddh: Prevention Versus Operationmentioning

confidence: 99%

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Introductory Chapter: Five-Dimensional Approach to the Developmental Dysplasia of the Hip

Spasovski¹

2017

Developmental Diseases of the Hip - Diagnosis and Management

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Developmental dysplasia of the hip (DDH) is not a specific disorder; it is rather a scale of overlapping and transforming conditions. It ranges from occult dysplasia seen on ultrasound screening of newborns, neonatal hip instability and dislocated hip whether reducible by orthopaedic manipulation or not. The hallmark of DDH is acetabular dysplasia-abnormality in size, shape or orientation of acetabulum. A thoughtful elucidation regarding DDH is that it is 'a common and preventable cause of childhood disability' [1]. Complications and consequences of DDH make this time interval much longer, though.

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Section: Natural History Of Ddh: Prevention Versus Operationmentioning

confidence: 99%

Section: Natural History Of Ddh: Prevention Versus Operationmentioning

confidence: 99%

Introductory Chapter: Five-Dimensional Approach to the Developmental Dysplasia of the Hip

Spasovski¹

2017

Developmental Diseases of the Hip - Diagnosis and Management

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“…Hip arthroplasty for DDH is complex surgery, and the cost of this procedure is more than a hip arthroplasty for primary osteoarthritis. Increased degree of dysplasia according to Crowe classification has been associated with higher costs [65].…”

Section: Femoral Partmentioning

confidence: 99%

Total Hip Replacement in Developmental Dysplasia of the Hip: Pitfalls and Challenges

Korkmaz¹,

Malkoç²

2017

Developmental Diseases of the Hip - Diagnosis and Management

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Introduction: Surgical treatment methods for developmental dysplasia of the hip (DDH) in the elderly patients contain pelvic or periacetabular osteotomy and hip arthroplasty. Total hip arthroplasty (THA) is the last and definitive surgical treatment modality for the end stage developmental dysplasia of the hip. Deformity classification and reconstruction:Crowe classification system describes the degree of dysplasia and gives information about the reconstruction procedure with hip arthroplasty. Classification is based on the magnitude of proximal femoral migration relative to the acetabulum. Acetabular component must be implanted to the true acetabulum for the optimal range of motion and stability of the reconstructed hip. The femoral component must be placed in neutral or slight anteversion but narrow femoral canal can be a problem for the reconstruction of femur. Conclusion-key results:The results of total hip arthroplasty in developmental dysplasia of the hip have been satisfactory for stability, mobility, and pain relief. The survivorship of cemented arthroplasty in dysplastic hips is inferior because of the young age of the patients and the complexity of the procedures. Early and midterm results of cementless hip arthroplasty are better. Most important complications after the surgery are dislocation of the reconstructed hip and sciatic nerve injury.

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“…However, there are still a few patients who suffer re-dislocation, residual hip dysplasia, residual acetabular dysplasia or osteoarthritis (Carney et al 2005, Thomas et al 2007. Most of these patients have to undergo total hip arthroplasty before the age of 50, causing the patients themselves and their family great psychological and economic burden (Ashraf et al 2014). In-depth analysis of the molecular mechanism underlying development of this disease and study of the proteins or genes that play key roles in this process should help with screening and identification of these patients.…”

Section: Introductionmentioning

confidence: 99%

The H19/let-7 feedback loop contributes to developmental dysplasia and dislocation of the hip

Niu

Jin²,

Wang³

et al. 2019

Physiol Res

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Developmental dysplasia and dislocation of the hip (DDH) is the most common type of lower limb deformity in pediatric orthopedics. The mechanism of the signaling pathway has been studied in depth. However, the role of epigenetic regulation, such as lncRNA, is still far from clear. In this study, we successfully established a rat model of DDH and demonstrated that H19 was down-regulated in the development of DDH. Further, we constructed H19 knockdown (KD) and overexpression chondrocytes. H19 KD suppressed the proliferation of normal chondrocytes, while overexpression of H19 promoted cell proliferation of DDH chondrocytes. Finally, we revealed that H19 bound to let-7 and inhibited its function, acting as a competing endogenous RNA. Down-regulation of H19 is closely associated with DDH progression and H19 is an important epigenetic factor that regulates the proliferation of chondrocytes. H19 may thus be a potential clinical marker for DDH diagnosis and treatment.

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Hospital Costs of Total Hip Arthroplasty for Developmental Dysplasia of the Hip

Abstract: Level IV, economic and decision analyses. See Guidelines for Authors for a complete description of levels of evidence.

Cited by 27 publications

References 24 publications

Introductory Chapter: Five-Dimensional Approach to the Developmental Dysplasia of the Hip

Introductory Chapter: Five-Dimensional Approach to the Developmental Dysplasia of the Hip

Total Hip Replacement in Developmental Dysplasia of the Hip: Pitfalls and Challenges

The H19/let-7 feedback loop contributes to developmental dysplasia and dislocation of the hip

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