Hospital Effluents and Wastewater Treatment Plants: A Source of Oxytetracycline and Antimicrobial-Resistant Bacteria in Seafood

McCarthy, Bozena; Apori, Samuel Obeng; Giltrap, Michelle; Bhat, Abhijnan; Curtin, James F.; Tian, Furong

doi:10.3390/su132413967

Cited by 8 publications

(2 citation statements)

References 92 publications

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“…As such, the potential inadvertent and sustained release of carbapenem-resistant A. baumannii into the environment through hospital wastewater portends important public health ramifications. Establishment in these ecological niches, e.g., in biofilms, is associated with increased risk of spread of resistance genes on mobile genetic elements to other A. baumannii and non- Acinetobacter species ( 22 , 35 ).…”

Section: Introductionmentioning

confidence: 99%

NDM-1- and OXA-23-producing Acinetobacter baumannii in wastewater of a Nigerian hospital

Odih,

Sunmonu,

Okeke

et al. 2023

Microbiol Spectr

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Carbapenem-resistant Acinetobacter baumannii spp. are increasingly important pathogens with limited treatment options, and there is limited knowledge on the environmental factors contributing to their spread. We determined the occurrence of carbapenem-resistant A. baumannii in hospital wastewater and their phylogenetic relationships with clinical A. baumannii isolates. Grab samples of raw and treated hospital wastewater were collected monthly at the University College Hospital, Ibadan, Nigeria, between March 2021 and February 2022. Acinetobacter baumannii strains were selectively isolated and identified using VITEK2, and their whole genomes were sequenced on an Illumina platform. We performed antimicrobial susceptibility testing and in silico genomic characterization of the strains and determined their phylogenetic relationships to previously characterized clinical A. baumannii strains from Nigeria. A. baumannii complex isolates were recovered from wastewater throughout the study. Of the 82 isolates identified based on whole-genome sequences, 77 were A. baumannii. A. baumannii isolates had high resistance rates (≥48.1%) to 10 of 12 antimicrobials tested, and majority (42/77, 54.5%) were resistant to carbapenems, with bla NDM-1 being the most common (24/77, 31.2%) carbapenem resistance gene detected, followed by bla OXA-23 ( n = 22, 28.6%). There was no statistically significant difference in carbapenem resistance rates or carbapenem gene carriage between the raw and treated wastewater isolates. Most of the isolates belonged to novel or sparsely described lineages, some of which were closely related to clinical isolates. The release of inadequately treated hospital wastewater into the environment may contribute to the increased spread of carbapenem-resistant and clinically important A. baumannii lineages in Ibadan, Nigeria. IMPORTANCE Acinetobacter baumannii is a leading cause of hospital-associated infections globally. A. baumannii reservoirs outside hospital settings are still unknown, and their occurrence in the environment is linked to clinical and anthropogenic activities. Although the risk of transmission of A. baumannii from environmental sources to humans is not fully understood, these sources pose significant risks for the continued dissemination of A. baumannii and their resistance traits. This study provides evidence that diverse and clinically relevant A. baumannii strains, many of which are resistant to carbapenems, are constantly being discharged into the environment through inadequately treated hospital wastewater. We further elucidate potential transmission routes between the environment and clinical infections and demonstrate the high prevalence of carbapenem resistance genes on highly mobile transposons among these strains. Our findings highlight the pressing need to address hospital wastewater as a crucial factor in curtailing the spread of carbapenem-resistant A. baumannii .

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Section: Introductionmentioning

confidence: 99%

NDM-1- and OXA-23-producing Acinetobacter baumannii in wastewater of a Nigerian hospital

Odih,

Sunmonu,

Okeke

et al. 2023

Microbiol Spectr

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“…In most countries, including India (Balakrishna et al, 2017) and Spain (Gutierrez-Sanchez et al, 2022), very few studies were carried out for the treatment of hospital wastewater. However, a large amount of untreated wastewater is discharged from hospitals (McCarthy et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Cephalosporin and Heavy Metal Resistance of Aeromonas hydrophila and Pseudomonas aeruginosa Strains Isolated from Hospital Sewage in Türkiye

Matyar

2023

Acta Aquatica Turcica

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In this work 89 Aeromonas hydrophila and 88 Pseudomonas aeruginosa isolates was recovered from university hospital sewage in Turkey. The resistance of these bacterial isolates to 11 different cephalosporin classes’ antibiotics belonging four generations and to 4 heavy metals was investigated. Among the A. hydrophila isolates it found high incidence of resistance to cefazolin (98.9%), cefaclor (98.9%) and cefprozil (97.8%). Resistance to cefoxitin (30.3%), cefepime (30.3%) and ceftazidime (31.4%) found relatively low. Among the P. aeruginosa isolates resistance to cefazolin (100%), cefuroxime (100%), cefoxitin (100%), cefaclor (100%), cefprozil (98.9%), cefixime (96.6%) and ceftizoxime (85.2%) was found very high. In contrast, none of the P. aeruginosa isolates showed resistance to ceftazidime, cefepime and cefpirome. Among the A. hydrophila isolates multiple antibiotic resistance (MAR) index ranged from 0.27 to 1.0 and among the P. aeruginosa MAR index ranged from 0.46 to 0.72. All of the A. hydrophila and P. aeruginosa isolates showed resistance to cadmium. Whereas, A. hydrophila and P. aeruginosa isolates showed a low resistance to lead of 6.7% and 2.2% respectively. Results indicate that both of the species are easily recovered hospital sewage and these species are gained resistance different generation of cephalosporins and heavy metals.

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Nanotechnology strategy for inhibition of PARP1 and IL-17A-associated with neurotoxicity in rats exposed to hospital wastewater

Sabry,

Ali,

Osman

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Hospital wastewater (HWW) poses a serious hazard to human health security concerning its high susceptibility to neurodegeneration. Water sources and ecosystems are exposed to a complicated pollution load from a variety of refractory organics and pharmaceutical active composites. This study evaluates the treated newly developed nanocomposite (NiFe2O4) HWW on the neural injury induced by HWW action in rats. Three groups of male Wistar rats were distributed, with eight rats in each: group I: tap water served as a control; group II: HWW; and group III: nano-HWW. Each group was intragastrical administrated with each type of water (2.5 ml/100 g b.wt/6 h) for 28 consecutive days. The open field test and Morris Water Maze assessed behavioral activity and spatial learning 2 days before the last day. The research demonstrated that HWW treated with nanocomposite (NiFe2O4) may exert decreased risks of the neural impairment effect of HWW. This improvement was achieved by reducing the neurotoxicity by lowering nitric oxide contents, lipid peroxidation, acetylcholinesterase, interleukin-17A (IL-17A), and poly(ADP-ribose) polymerase1(PARP1) while restoring the antioxidant biomarkers and neurotransmitter levels (β-endorphin, norepinephrine, dopamine, and serotonin) of the treated groups in the cortex and brainstem and enhancement of the histopathology of the cortex as well. In conclusion, this study introduced a newly developed nanotechnology application for treating HWW to protect from neural injury. The findings of this research have significant value for policymakers, Ministry of Health management, and environmental organizations in their selection of suitable techniques and procedures to optimize hospital wastewater treatment efficiency.

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Hospital Effluents and Wastewater Treatment Plants: A Source of Oxytetracycline and Antimicrobial-Resistant Bacteria in Seafood

Cited by 8 publications

References 92 publications

NDM-1- and OXA-23-producing Acinetobacter baumannii in wastewater of a Nigerian hospital

NDM-1- and OXA-23-producing Acinetobacter baumannii in wastewater of a Nigerian hospital

Investigation of Cephalosporin and Heavy Metal Resistance of Aeromonas hydrophila and Pseudomonas aeruginosa Strains Isolated from Hospital Sewage in Türkiye

Nanotechnology strategy for inhibition of PARP1 and IL-17A-associated with neurotoxicity in rats exposed to hospital wastewater

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