Hospital Mortality of Patients with Severe Traumatic Brain Injury is Associated with Serum PTX3 Levels

Gullo, Jackson da Silva; Bertotti, Melina Moré; Silva, Cláudia Carvalho Pestana; Schwarzbold, Marcelo Libório; Diaz, Alexandre Paim; Soares, Flávia Mahatma Schneider; Freitas, Fernando Cini; Nunes, Jean Costa; Pinheiro, José T.; Morato, Edelton Flávio; Prediger, Rui Daniel; Linhares, Marcelo Neves; Walz, Roger

doi:10.1007/s12028-010-9462-y

Cited by 41 publications

(29 citation statements)

References 24 publications

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“…5). These observations appear to be in agreement with previous observations associating hyperocagulopathy and disease severity arising from increased TF expression (29)(30)(31)(32)(33)(34)(35)(36)(37)69); however, the causal link between PTX3 production and pathology/disease severity in A. baumannii sepsis requires further elucidation.…”

Section: Figsupporting

confidence: 92%

Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3

et al. 2014

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Section: Figsupporting

confidence: 92%

Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3

et al. 2014

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“…IL-10 enhances the pentraxin 3 (PTX3), a humoral component of the innate immune system, production by dentritic cells of myelomonocytic origin [26], and recently we have demonstrated that serum PTX3 levels are also independently associated with hospital mortality in patients with severe TBI [9]. Taken together, these findings may suggest an interaction or independent participation of IL-10 and PTX3 in TBI-induced immunological changes.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 Is an Independent Biomarker of Severe Traumatic Brain Injury Prognosis

Soares

Souza²,

Schwarzbold

et al. 2012

Neuroimmunomodulation

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Background: Cytokines have been shown to be involved in traumatic brain injury (TBI). We investigated the independent association between serum levels of IL-10 and TNF-α and hospital mortality of patients with severe TBI. Methods: Serum IL-10 and TNF-α levels were determined after a median period (interquartile range (IQ) 25–75) of 10 h (IQ 5–18) after severe TBI in 93 consecutive patients and in randomly selected patients with mild (n = 18) and moderate (n = 16) TBI. In patients with severe TBI, additional blood samples were analyzed 30 h (IQ 22–37) and 68 h (IQ 55–78) after TBI. Age, gender, computed tomography findings, Glasgow Coma Scale score (GCS) and pupil reactions at admission, associated trauma and hospital mortality were collected. Results: Elevated serum levels of IL-10, but not TNF-α, correlated significantly with GCS severity (R² coefficient, p < 0.0001) and were found to be associated with hospital mortality in patients with severe TBI. Elevated IL-10 remained associated with mortality (p = 0.01) in a subset of patients with isolated severe TBI (n = 74). Multiple logistic regression analysis showed that higher IL-10 levels (>90 pg/ml) at 10 or 30 h after TBI were 6 times (odds ratio (OR) 6.2, 95% confidence interval (CI) 1.2–25.1, p = 0.03) and 5 times (OR 5.4, 95% CI 1.2–25.1, p = 0.03), respectively, more frequently associated with hospital mortality than lower levels (<50 pg/ml), independently of age, GCS as well as pupil reactions at admission and associated trauma. Conclusions: Serum IL-10 levels may be a useful marker for severe TBI prognosis.

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“…This would at least partially explain the association between plasma PTX3 levels and rehabilitative outcome in cardiac surgery patients. In addition, it has recently been found that pentraxin predicts higher hospital mortality in patients with severe traumatic brain injury, 33 that it is a useful marker of severe disease in febrile patients attending an emergency department, 34 and that it predicts of cognitive impairment in elderly hypertensive patients. 35 In the absence of previous evidence concerning the role of PTX3 in exercise training or rehabilitation, this may simply be because the complexity and integration of the physiological mechanisms involved in functional recovery after cardiac surgery is better reflected by a molecule that is largely produced by activated endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Ferratini

Ripamonti

Masson

et al. 2012

Journal of Cardiopulmonary Rehabilitation and Prevention

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■ BACKGROUND: Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation.■ METHODS: This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables.■ RESULTS: The patients (69.5% men, mean age of 67 Ϯ 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG

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Hospital Mortality of Patients with Severe Traumatic Brain Injury is Associated with Serum PTX3 Levels

Abstract: Serum PTX3 levels after severe TBI are independently associated with higher hospital mortality and may be a useful marker of TBI and its prognosis.

Cited by 41 publications

References 24 publications

Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3

Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3

Interleukin-10 Is an Independent Biomarker of Severe Traumatic Brain Injury Prognosis

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

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