Hospital Outbreak of Hepatitis a Secondary to Blood Exchange in a Baby

Seeberg, Staffan

doi:10.1016/s0140-6736(81)92318-7

Cited by 72 publications

(24 citation statements)

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“…tor concentrates may have had a role in that city. The non hemophiliac contacts may reflect contact transmission that can result from transfusion-transmitted infection [15,16], In addition, there are indications that the incidence of HAV infection has been declining in Southern Italy. In 1988, D'Argenio et al [17] in Naples found that children from 7 to 11 years of age had an overall anti-HAV preva lence of 11.2%.…”

Section: Potential Séroconversionsmentioning

confidence: 99%

Hepatitis A Virus Transmission by Blood Products in the United States

Mosley¹,

Nowicki²,

Kasper³

et al. 1994

Vox Sanguinis

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To address the question of HAV prevalence and seroconversion in relation to clotting factor concentrates, we assayed an early serum for 339 hemophiliacs followed every 6 months by the Transfusion Safety Study in the period from mid-1985 until mid-1992. We found 58.4% positive around entry, with an age-specific prevalence that did not vary with age. In comparison to rates for anti-HIV-negative blood donors, they were significantly higher. Based on testing of subsequent sera, 11 hemophiliacs (7.8% of 141 susceptibles) changed their anti-HAV status from negative to positive. In 9 instances, positivity immediately followed the first dose of intravenous immune globulin. A possible seroconversion followed treatment with blood components, and a possible seroconversion followed intermediate-purity, solvent/detergent(SD)-treated factor VIII concentrate. Neither of these 2 patients was anti-HAV IgM positive, so that passively transferred antibody is possible. The high prevalence among hemophiliacs at entry must be further investigated by determining the expected background rate in a US population similar to the hemophilia patients, and by comparing anti-HAV prevalence associated with SD-treated and heat-inactivated concentrates.

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Section: Potential Séroconversionsmentioning

confidence: 99%

Hepatitis A Virus Transmission by Blood Products in the United States

Mosley¹,

Nowicki²,

Kasper³

et al. 1994

Vox Sanguinis

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“…The ALT lev¬ el reached a peak value of 261IU/L on day 43, then declined to normal levels by day 63. IgM-specific anti-HAV was detected initially on day 31 (nonreactive on day 28).…”

Section: Experimental Chimpanzee Transmission Studiesmentioning

confidence: 99%

Posttransfusion Hepatitis Type A

Hollinger¹

1983

JAMA

124

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“…These cases of transmission made it clear that HAV can be transmitted by plasma derivatives. In the early 1980s, there were also some reports of HAV transmission following blood transfusions [40][41][42][43][44]. In the last few years, no suspected cases of HAV transmission associated with the use of blood components have been reported to the PEI.…”

Section: Transmissibilitymentioning

confidence: 99%

Hepatitis A Virus

2001

Transfus Med Hemother

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1 Current Knowledge about the Pathogen 1.1 Characteristics of Hepatitis A Virus The clinical features of hepatitis A have been known for a long time. However, the pathogen (hepatitis A virus (HAV)) was firstly identified in 1973 with the aid of immune electron microscopy [1]. HAV is classified in the family of Picornaviridae , genus Hepatovirus . It is a small, spherical, non-enveloped virus with a diameter of approximately 30 nm. The capsid of the viral particle is made up of 60 copies of the three viral structural proteins VP1–VP3. The genome consists of a single- stranded (+)sense RNA molecule of 7,500 bases in length. The 5'' end of the genome is covalently bound to a small protein (VPg). The genome serves as messenger RNA and can be divided into three regions: a long open-reading frame (ORF) is flanked by the non-coding 5'' region and the non-coding 3'' region. The ORF encodes a polyprotein which is cleaved by proteolysis into the mature viral proteins. Two thirds of the genome code for non-structural proteins with enzymatic and regulatory functions. Translation is controlled by an ‘internal ribosomal entry site’ (IRES) located within the non-coding 5'' region [2]. Only one serotype of HAV has been identified so far. Analysis of HAV genome sequences has revealed 6 genotypes to date [3], with genotype I predominating worldwide. Genotypes IV–VI have only been observed in Old World monkeys. ...

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Hospital Outbreak of Hepatitis a Secondary to Blood Exchange in a Baby

Cited by 72 publications

References 0 publications

Hepatitis A Virus Transmission by Blood Products in the United States

Hepatitis A Virus Transmission by Blood Products in the United States

Posttransfusion Hepatitis Type A

Hepatitis A Virus

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