Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years

Hauviller, Laurent; Eyvrard, Frédéric; Garnault, Valérie; Rousseau, Vanessa; Molinier, Laurent; Montastruc, J. L.; Bagheri, Haleh

doi:10.1007/s00228-016-2022-4

Cited by 18 publications

(38 citation statements)

References 24 publications

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“…Of the 19 studies, 9 measured DRP‐related readmissions, 7 measured ADRs, 2 measured ADEs, and 1 measured readmissions due to drug‐drug interactions . No study specifically examined readmissions due to MEs.…”

Section: Resultsmentioning

confidence: 99%

“…Good similarity was observed between the reviewers for screening (interrater agreement: κ = 0.78). Of the 19 studies, 17 (89%) were observational, including 11 retrospective studies, 4 prospective studies, and 2 case‐control studies . The remaining 2 studies were a randomized controlled trial and a before‐after study (Appendix ).…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of drug‐related readmissions could be extracted in 12 of 19 studies that reported readmission rates at the individual level (Appendix ). Rates of readmission due to drugs varied between studies (range 3–64%, median 21%, IQR 14–23%).…”

Section: Resultsmentioning

confidence: 99%

“…Preventability rates were reported in 8 studies but could be extracted in 4 studies at the individual level (Appendix ). Readmissions were deemed potentially preventable in 5% to 87% of all drug‐related readmissions (median 69%, IQR 19–84%); if the outlier (study with 5%) was excluded, the median increased to 76% (IQR 61–87%).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence and Preventability of Drug‐Related Hospital Readmissions: A Systematic Review

Morabet

Uitvlugt

Bemt

et al. 2018

J American Geriatrics Society

165

162

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Preventability of Drug‐Related Hospital Readmissions: A Systematic Review

Morabet

Uitvlugt

Bemt

et al. 2018

J American Geriatrics Society

165

162

View full text Add to dashboard Cite

show abstract

“…Other studies that have identified medication-related hospitalizations have relied on clinician review of medical charts and used variable and subjective criteria. [4][5][6][7] Future research should use the Naranjo algorithm with clinician chart review to determine whether a collaborative interprofessional practice model affects the rate of medication-related ED visits and hospitalizations.…”

mentioning

confidence: 99%

Reply to: Impact of Post discharge Contact by Health care Team

Reidt

Holtan

Larson

et al. 2017

J American Geriatrics Society

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Prescribing pattern insights from a longitudinal study of older adult inpatients with polypharmacy and chronic non‐cancer pain

Goetschi,

Verloo,

Wernli

et al. 2024

European Journal of Pain

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BackgroundThe present study sought to determine the prevalence of chronic non‐cancer pain (CNCP) among older adult inpatients with polypharmacy. It also aimed to analyse prescription patterns and assess the therapy adequacy and patient complexity for those with and without CNCP.MethodsThis 4‐year longitudinal study examined data from an exhaustive acute care hospital register on home‐dwelling older adult patients (≥65) with polypharmacy. Commonly known combinations of potentially inappropriate medications were used to estimate therapy adequacy. Patient complexity was evaluated by comparing number of comorbidities and investigating physical and cognitive deficits.ResultsWe determined a prevalence of CNCP of 9.7% among all older adult inpatients with polypharmacy, rising to 11.3% for those aged ≥85. Overall, CNCP patients were prescribed more drugs and had more comorbidities and physical and cognitive deficits than patients without CNCP. Older adult patients with CNCP received more analgesics, greater quantities of opioids, paracetamol and co‐analgesics and elevated opioid dosages. Older adult patients with CNCP aged ≥85 received fewer analgesics, opioids, non‐steroidal anti‐inflammatory drugs and co‐analgesics but more paracetamol. Older adult patients with CNCP were prescribed more potentially inappropriate medications involving opioids. In particular, 24.5% received an opioid and a hypnotic (benzodiazepine or Z‐drug), and 8.6% received an opioid and a gabapentinoid.ConclusionObserved differences in medication use between older adult inpatients with or without CNCP may be relevant for clinical practice. Potentially inadequate co‐prescribing (such as hypnotics and opioids) affects a higher proportion of patients with CNCP and may have serious unintended consequences.Significance StatementThis study describes differences in prescription patterns between people with and without chronic non‐cancer pain in a large dataset of 20,422 discharges. The differences found may be relevant to clinical practice. In particular, high co‐prescribing of opioids and hypnotics may have serious unintended consequences. Greater physical and cognitive deficits may indicate greater patient complexity, and appropriate interventions need to be developed to improve the management of this vulnerable patient group.

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Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years

Abstract: This study shows an estimated rate of re-admission for an ADR around 87/1000 within 1 year, and the same drug combination were the suspected cause of repeat admission in half the cases. At least, 11 % of cases were avoidable.

Cited by 18 publications

References 24 publications

Prevalence and Preventability of Drug‐Related Hospital Readmissions: A Systematic Review

Prevalence and Preventability of Drug‐Related Hospital Readmissions: A Systematic Review

Reply to: Impact of Post discharge Contact by Health care Team

Prescribing pattern insights from a longitudinal study of older adult inpatients with polypharmacy and chronic non‐cancer pain

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