Hospital Resource Utilization and Costs of Inappropriate Treatment of Candidemia.

Arnold, Heather; Micek, ST; Zilberberg,; Shorr, AF; Kothari, Smita; Labelle, AJ; Kollef, MH

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2476

Cited by 26 publications

(36 citation statements)

References 17 publications

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“…loodstream infections (BSIs) caused by yeasts can cause devastating complications and markedly increase the costs of hospital care (1). Mortality remains high, especially when effective antifungal drug therapy is not promptly administered (3,9,24).…”

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confidence: 99%

Direct MALDI-TOF Mass Spectrometry Assay of Blood Culture Broths for Rapid Identification of Candida Species Causing Bloodstream Infections: an Observational Study in Two Large Microbiology Laboratories

et al. 2012

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We evaluated the reliability of the Bruker Daltonik's MALDI Biotyper system in species-level identification of yeasts directly from blood culture bottles. Identification results were concordant with those of the conventional culture-based method for 95.9% of Candida albicans (187/195) and 86.5% of non-albicans Candida species (128/148). Results were available in 30 min (median), suggesting that this approach is a reliable, time-saving tool for routine identification of Candida species causing bloodstream infection.

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mentioning

confidence: 99%

Direct MALDI-TOF Mass Spectrometry Assay of Blood Culture Broths for Rapid Identification of Candida Species Causing Bloodstream Infections: an Observational Study in Two Large Microbiology Laboratories

et al. 2012

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“…Candidaemia is generally difficult to diagnose and treat and mortality rates remain at approximately 50%, with great costs to the healthcare system (Gudlaugsson et al 2003, Colombo et al 2008, Arnold et al 2010.…”

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confidence: 99%

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Wille¹,

Guimarães²,

Furtado

et al. 2013

Mem. Inst. Oswaldo Cruz

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“…C. albicans is the species most frequently responsible for invasive candidiasis, although according to Bille et al (2012), other non-albicans species, including C. tropicalis, C. parapsilosis, C. glabrata and C. krusei, are becoming increasingly common. According to Arnold et al (2010), fungal infections affect the length of hospital stay and increase treatment costs, so it is very important to correctly identify the fungi causing infection in order to promptly administrate targeted treatment. The results of the present study indicate that with sample processing and MALDI-TOF Biotyper analysis, microorganisms can be rapidly and reliably identified directly from bottles of positive blood cultures in 45 min.…”

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confidence: 99%

Direct identification of yeasts from blood culture by MALDI-TOF mass spectrometry

Kouadio-Yapo¹,

Hasseine²,

Delaunay³

et al. 2018

Afr. J. Microbiol. Res.

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This study aimed to identify yeasts directly from positive blood cultures by MALDI-TOF mass spectrometry. This was a 5-month prospective study (February to June, 2015) carried out on bottles of blood cultures from in-patients at the Hôpital de l'ARCHET at the CHU, Nice. Positive blood culture broth was analysed by MALDI-TOF mass spectrometry using Sodium Dodecyl Sulphate (SDS) as the lysis buffer. Out of 64 samples, 51 (79.6%) were identified by MALDI-TOF mass spectrometry at the species level and 12 strains (18.7%) at the genus level. The isolated yeasts fell into six species: Candida albicans 37.2%, Candida glabrata 31.4%, Candida parapsilosis 15.7%, Candida tropicalis 5.9%, Candida krusei 5.9%, and Candida lusitaniae 3.9%. In comparison, 95.3% of species were identified from cultured colonies, the main ones being C. albicans (37.1%), C. glabrata (30.7%) and C. parapsilosis (16.1%). Identification of yeasts from blood culture bottles by MALDI-TOF mass spectrometry is a fast, reliable technique. However, analysis of colonies remains the best technique for identification and for antifungal imaging in order to refer the patient to the most appropriate therapy.

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Hospital Resource Utilization and Costs of Inappropriate Treatment of Candidemia.

Cited by 26 publications

References 17 publications

Direct MALDI-TOF Mass Spectrometry Assay of Blood Culture Broths for Rapid Identification of Candida Species Causing Bloodstream Infections: an Observational Study in Two Large Microbiology Laboratories

Direct MALDI-TOF Mass Spectrometry Assay of Blood Culture Broths for Rapid Identification of Candida Species Causing Bloodstream Infections: an Observational Study in Two Large Microbiology Laboratories

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Direct identification of yeasts from blood culture by MALDI-TOF mass spectrometry

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